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Anti-Oxytocin-neurophysin 1抗体(ab2078)

Reviews (2)Q&A (3)References (15)

Key features and details

  • Rabbit polyclonal to Oxytocin-neurophysin 1
  • Suitable for: IHC-P, ICC/IF, IHC-FoFr
  • Reacts with: Mouse, Rat, Sheep, Rabbit, Guinea pig, Human, Pig
  • Isotype: IgG

概述

  • 产品名称

    Anti-Oxytocin-neurophysin 1抗体
    参阅全部 Oxytocin-neurophysin 1 一抗

  • 描述

    兔多克隆抗体to Oxytocin-neurophysin 1

  • 宿主

    Rabbit

  • 特异性

    Less than 1% reactivity to vasopressin.

  • 经测试应用

    适用于: IHC-P, ICC/IF, IHC-FoFrmore details

  • 种属反应性

    与反应: Mouse, Rat, Sheep, Rabbit, Guinea pig, Human, Pig

  • 免疫原

    Full length protein corresponding to Oxytocin-neurophysin 1. Oxytocin-thyroglobulin

  • 常规说明

    The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.

    If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As

性能

应用

The Abpromise guarantee

Abpromise™承诺保证使用ab2078于以下的经测试应用

“应用说明”部分 下显示的仅为推荐的起始稀释度；实际最佳的稀释度/浓度应由使用者检定。

应用 Ab评论 说明
IHC-P (1)
Use at an assay dependent concentration.
ICC/IF
Use at an assay dependent concentration.
IHC-FoFr
Use at an assay dependent concentration. PubMed: 20043984
说明
IHC-P
Use at an assay dependent concentration.
ICC/IF
Use at an assay dependent concentration.
IHC-FoFr
Use at an assay dependent concentration. PubMed: 20043984

靶标

  • 相关性

    Neurophysin 1 specifically binds oxytocin. Oxytocin causes contraction of the smooth muscle of the uterus and of the mammary gland. Oxytocin is a posterior pituitary hormone which is synthesized as an inactive precursor in the hypothalamus along with its carrier protein neurophysin I. Together with neurophysin, it is packaged into neurosecretory vesicles and transported axonally to the nerve endings in the neurohypophysis, where it is either stored or secreted into the bloodstream. Oxytocin contracts smooth muscle during parturition and lactation. It is also involved in cognition, tolerance, adaptation and complex sexual and maternal behaviour, as well as in the regulation of water excretion and cardiovascular functions.

  • 细胞定位

    Secreted

  • 数据库链接

    • 别名

      • MGC126890 antibody
      • MGC126892 antibody
      • Neurophysin 1 antibody
      • Neurophysin I antibody
      • Ocytocin antibody
      • OT antibody
      • OT NPI antibody
      • OXT antibody
      • Oxytocin antibody
      • Oxytocin Neurophysin preproprotein antibody
      • Oxytocin prepro (neurophysin I) antibody
      • Oxytocin prepropeptide antibody
      • Oxytocin-neurophysin 1 antibody
      see all

    文献 (15)

    发表研究结果有使用 ab2078？请让我们知道，以便我们可以引用本数据表中的参考文章。

    ab2078 被引用在 15 文献中.

    • Ogata K  et al. Lavender Oil Reduces Depressive Mood in Healthy Individuals and Enhances the Activity of Single Oxytocin Neurons of the Hypothalamus Isolated from Mice: A Preliminary Study. Evid Based Complement Alternat Med 2020:5418586 (2020). PubMed: 32733584
    • Song TJ  et al. Altered Behaviors and Impaired Synaptic Function in a Novel Rat Model With a Complete Shank3 Deletion. Front Cell Neurosci 13:111 (2019). PubMed: 30971895
    • Mohan S  et al. Oxytocin is present in islets and plays a role in beta-cell function and survival. Peptides 100:260-268 (2018). IF . PubMed: 29274352
    • Zhang B  et al. Central insulin action induces activation of paraventricular oxytocin neurons to release oxytocin into circulation. Sci Rep 8:10415 (2018). PubMed: 29991705
    • Dai D  et al. Direct Involvement of Androgen Receptor in Oxytocin Gene Expression: Possible Relevance for Mood Disorders. Neuropsychopharmacology 42:2064-2071 (2017). PubMed: 28447621
    View all Publications for this product

    客户评价及客户问答

    Show All 评价 Q&A
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    1-5 of 5 Abreviews or Q&A

    Immunohistochemistry (Frozen sections) abreview for Anti-Oxytocin-neurophysin 1 antibody

     Good
    Abreviews
    abreview image
    Application
    Immunohistochemistry (Frozen sections)
    Sample
    Mouse Tissue sections (Brain)
    Permeabilization
    Yes - 0.1% Triton X-100
    Specification
    Brain
    Blocking step
    Serum as blocking agent for 24 hour(s) and 0 minute(s) · Concentration: 10% · Temperature: 4°C
    Fixative
    Paraformaldehyde
    Read More
    The reviewer received a reward from Abcam’s Loyalty Program in thanks for submitting this Abreview and for helping the scientific community make better-informed decisions.

    Kevin Zhang

    Verified customer

    提交于 Jan 31 2018

    Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) abreview for Anti-Oxytocin antibody

     Good
    Abreviews
    abreview image
    Application
    Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
    Blocking step
    hydrogen peroxide as blocking agent for 10 minute(s) · Concentration: 3% · Temperature: 25°C
    Antigen retrieval step
    Heat mediated - Buffer/Enzyme Used: citrate, pH6.0, 100C 20 min
    Sample
    Human Tissue sections (placenta)
    Specification
    placenta
    Permeabilization
    No
    Fixative
    Formaldehyde
    Read More
    The reviewer received a reward from Abcam’s Loyalty Program in thanks for submitting this Abreview and for helping the scientific community make better-informed decisions.

    Abcam user community

    Verified customer

    提交于 Jul 01 2014

    Question

    Dear ladies and gentleman, I am interestet in the anti-OT and anti-AVP antibodies from this paper: PLoS One. 2011;6(8):e23362. Epub 2011 Aug 17. Oxytocin and vasopressin involved in restraint water-immersion stress mediated by oxytocin receptor and vasopressin 1b receptor in rat brain. Zhao DQ, Ai HB. unfortunately in the refference list of all of your antibodies i couldn´t find this paper, although they had their antibodies from your company. can you please help me?

    Read More
    Answer

    Thank you for your inquiry. Unfortunately, we are unable to track down the particular antibodies the authors used when it is not specifically mentioned in the paper. However, the following antibodies might have been used: ab39363: anti-Vasopressin (AVP), guaranteed to work in immunohistochemistry (PFA perfusion fixed frozen sections and frozen sections, IHC-FoFr, IHC-Fr) on rat. Click here (or use the following: https://www.abcam.com/Vasopressin-antibody-ab39363.html). ab2078: anti-Oxytocin, guaranteed to work in RIA and immunohistochemistry (PFA perfusion fixed frozen sections and paraffin-embedded sections, IHC-FoFr, IHC-P) on rat. Click here (or use the following: https://www.abcam.com/Oxytocin-neurophysin-1-antibody-ab2078.html). ab11143: anti-Oxytocin, guaranteed to work in immunohistochemistry (frozen sections, IHC-Fr) on rat. Click here (or use the following: https://www.abcam.com/Oxytocin-neurophysin-1-antibody-ab11143.html). ab78364: anti-Oxytocin, guaranteed to work in ELISA and immunohistochemistry (PFA perfusion fixed frozen sections and paraffin-embedded sections, IHC-FoFr, IHC-P) on rat. Click here (or use the following: https://www.abcam.com/Oxytocin-neurophysin-1-antibody-4G11-ab78364.html). We are happy to reassure you that all of our products are covered by our Abpromise, which guarantees that the product will work in the applications and species specified on the datasheet, or we will offer a replacement, credit, or refund within 6 months of purchase. If the product is to be used in an untested species or application, you may be eligible for our testing discount program if the antibody has not yet been purchased. Please contact our Scientific Support team by replying to this email prior to purchase for more information. I hope this information is helpful. Please do not hesitate to contact us again with any other questions.

    Read More

    Question

    I am setting up an RIA to measure oxytocin in rabbit serum and thought your ab 2078 would work. On your website it is listed as having been tested for RIA, do you have a protocol available? Any information regarding this application of ab2078 would be appreciated.

    Read More
    Answer

    Thank you for your enquiry. I am sorry but we do not have an online RIA protocol. However, I would like to recommmend the following resources: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=716433&dopt=Abstract http://www.phoenixpeptide.com/qcdata/RIK/protocol10-1280_p.pdf http://faculty.washington.edu/jwingfie/protocols.html I hope this information helps, please do not hesitate to contact us if you need any more advice or information.

    Read More

    Question

    Thank you for your quick answer. I know that sometimes antibodies against vasopressin and oxytocin are using for immunostaining of vasotocin and isotocin. I would like to ask you if it's possible to use your antibodies ab8745 (anti-vasopressin) or ab2078 (anti- oxytocin) for vasotocin or isotocin staining? Could you inform me about cross-reaction of ab8745 and ab2078 with vasotocin or isotocin, please.I will be very grateful for your help.

    Read More
    Answer

    Thank you for your enquiry regarding our antibodies ab2078 and ab8745. Unfortunately we do not have any further information regarding their cross reactivity with vasotocin or isotocin, this has not been tested in our laboratories. I'm very sorry I couldn't help you more on this occasion,

    Read More

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