AB106368

Anti-OTUD4/HIN-1抗体

Name: OTUD4/HIN-1抗体 (ab106368)| Abcam中文官网
Brand: Abcam Limited
SKU: AB106368
Price: 4829 CNY
Availability: InStock
Rating: 4 (1 reviews)

Anti-OTUD4/HIN-1 antibody

(1 Review)

(4 Publications)

Rabbit Polyclonal OTUD4/HIN-1 antibody. Suitable for ICC, WB, ICC/IF and reacts with Human samples. Cited in 4 publications. Immunogen corresponding to Synthetic Peptide within Human OTUD4.

查看别名

HIN-1, KIAA1046, OTUD4, OTU domain-containing protein 4, HIV-1-induced protein HIN-1

3 Images

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Immunocytochemistry - Anti-OTUD4/HIN-1 antibody (AB106368)

ab106368, at 2.5 ug/ml, staining OTUD4/HIN-1 in Daudi cells by immunocytochemistry.

Immunocytochemistry/ Immunofluorescence - Anti-OTUD4/HIN-1 antibody (AB106368)

ICC/IF

Unknown

Immunocytochemistry/ Immunofluorescence - Anti-OTUD4/HIN-1 antibody (AB106368)

Immunofluorescence of OTUD4/HIN-1 in Daudi cells using ab106368 at 20 ug/ml.

Supplier Data

Western blot - Anti-OTUD4/HIN-1 antibody (AB106368)

Lane 1:

Western blot - Anti-OTUD4/HIN-1 antibody (ab106368) at 0.25 µg/mL

Lane 2:

Western blot - Anti-OTUD4/HIN-1 antibody (ab106368) at 0.5 µg/mL

All lanes:

Daudi (human Burkitt's lymphoma cell line) cell lysate

Predicted band size: 123 kDa

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关键信息

宿主种属

Rabbit

克隆

Polyclonal

亚型

IgG

不含载体蛋白

反应种属

Human

应用

WB, ICC, ICC/IF

applications

免疫原

Synthetic Peptide within Human OTUD4. The exact immunogen used to generate this antibody is proprietary information.

Q01804

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "ICC" : {"fullname" : "Immunocytochemistry", "shortname":"ICC"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "ICC-species-checked": "testedAndGuaranteed", "ICC-species-dilution-info": "2.5 µg/mL", "ICC-species-notes": "", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.25-0.5 µg/mL", "WB-species-notes": "", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "20 µg/mL", "ICCIF-species-notes": "" } } }

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性能和储存信息

形式

Liquid

纯化工艺

Affinity purification Immunogen

存储溶液

pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS

运输条件

Blue Ice

补充信息

This supplementary information is collated from multiple sources and compiled automatically.

OTUD4/HIN-1 also known as ovarian tumor domain-containing protein 4 is known for its deubiquitinating enzyme activity. This protein shows a molecular mass of approximately 135 kDa. It is expressed in various tissues with significant levels observed in the brain and kidneys. OTUD4 plays a role in regulating protein degradation by removing ubiquitin impacting cellular processes such as protein turnover cell cycle regulation and signaling pathways.

Biological function summary

The OTUD4 protein significantly influences cellular homeostasis and stress response. It participates in the protein quality control system as part of a complex that regulates the ubiquitin-proteasome system. This protein ensures the proper folding and degradation of misfolded proteins impacting cellular health and function. OTUD4 forms interactions with other proteins highlighting its role in modulating cellular stress responses and apoptosis.

Pathways

OTUD4 has connections with both the ubiquitin-proteasome and DNA damage response pathways. It participates in the modulation of these pathways ensuring that damaged or misfolded proteins do not accumulate. OTUD4 directly interacts with proteins such as ubiquitin-specific proteases and E3 ligases influencing apoptosis and stress response. These interactions reveal its involvement in cellular decisions related to repair survival or apoptosis.

OTUD4 shows associations with neurodegenerative diseases and certain cancers. Dysregulation in its function can relate to protein aggregation in neurodegenerative conditions with its expression affecting pathways related to proteins like Parkin and UCH-L1. In cancers changes in OTUD4 expression can impact tumor growth and survival pointing towards its potential for therapeutic targeting and biomarker use in these disorders.

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产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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靶点信息

Deubiquitinase which hydrolyzes the isopeptide bond between the ubiquitin C-terminus and the lysine epsilon-amino group of the target protein (PubMed : 23827681, PubMed : 25944111, PubMed : 29395066). May negatively regulate inflammatory and pathogen recognition signaling in innate immune response. Upon phosphorylation at Ser-202 and Ser-204 residues, via IL-1 receptor and Toll-like receptor signaling pathway, specifically deubiquitinates 'Lys-63'-polyubiquitinated MYD88 adapter protein triggering down-regulation of NF-kappa-B-dependent transcription of inflammatory mediators (PubMed : 29395066). Independently of the catalytic activity, acts as a scaffold for alternative deubiquitinases to assemble specific deubiquitinase-substrate complexes. Associates with USP7 and USP9X deubiquitinases to stabilize alkylation repair enzyme ALKBH3, thereby promoting the repair of alkylated DNA lesions (PubMed : 25944111).

See full target information OTUD4

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文献 (4)

Recent publications for all applications. Explore the full list and refine your search

Journal of virology 99:e0230924 PubMed40277358

2025

Ubiquitin-dependent proteasomal degradation of small hepatitis B virus surface antigen mediated by TRIM21 and antagonized by OTUD4.

Applications

Unspecified application

Species

Unspecified reactive species

Shuxiang Wu,Zhihan Chen,Zhengqian Zhang,Jing Xu,Hang Li,Mengxian Lin,Wenjie Xie,Yan Chen,Xinjian Lin,Xu Lin

iScience 26:108515 PubMed38089580

2023

Cyclophilin A facilitates influenza B virus replication by stabilizing viral proteins.

Applications

Unspecified application

Species

Unspecified reactive species

Huizi Li,Wenhui Fan,Jie Min,Xiaoyuan Bai,Wenxian Yang,Heqiao Li,Yuna Zhao,Runshan Lin,Xiaojuan Jia,Wenjun Liu,Lei Sun

Cell insight 2:100100 PubMed37193092

2023

The deubiquitinase OTUD4 inhibits the expression of antimicrobial peptides in Paneth cells to support intestinal inflammation and bacterial infection.

Applications

Unspecified application

Species

Unspecified reactive species

Keying Yu,Yu-Yao Guo,Tianzi Liuyu,Peng Wang,Zhi-Dong Zhang,Dandan Lin,Bo Zhong

PloS one 11:e0150364 PubMed26934049

2016

Expression Atlas of the Deubiquitinating Enzymes in the Adult Mouse Retina, Their Evolutionary Diversification and Phenotypic Roles.

Applications

IHC

Species

Unspecified reactive species

Mariona Esquerdo,Xavier Grau-Bové,Alejandro Garanto,Vasileios Toulis,Sílvia Garcia-Monclús,Erica Millo,Ma José López-Iniesta,Víctor Abad-Morales,Iñaki Ruiz-Trillo,Gemma Marfany

View all publications

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Anti-OTUD4/HIN-1抗体

Anti-OTUD4/HIN-1 antibody

Immunocytochemistry - Anti-OTUD4/HIN-1 antibody (AB106368)

Immunocytochemistry/ Immunofluorescence - Anti-OTUD4/HIN-1 antibody (AB106368)

Western blot - Anti-OTUD4/HIN-1 antibody (AB106368)