Anti-OTUD1抗体(ab122481)
Key features and details
- Rabbit polyclonal to OTUD1
- Suitable for: IHC-P
- Reacts with: Human
- Isotype: IgG
概述
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产品名称
Anti-OTUD1抗体 -
描述
兔多克隆抗体to OTUD1 -
宿主
Rabbit -
经测试应用
适用于: IHC-Pmore details -
种属反应性
与反应: Human
预测可用于: Mouse, Rat
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免疫原
antigen: SSAAEPVIVS RSDPRDEKLA LYLAEVEKQD KYLRQRNKYR FHIIPDGNCL YRAVSKTVYG DQSLHRELRE QTVHYIADHL DHFSPLIEGD VGEFIIAAAQ D, corresponding to internal sequence amino acids 272-372 of Human OTUD1 (Q5VV17).
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阳性对照
- IHC-P: Human lung, lymph node, duodenum, and liver tissues.
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常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. -
存储溶液
pH: 7.20
Preservative: 0.02% Sodium azide
Constituents: 59% PBS, 40% Glycerol (glycerin, glycerine) -
Concentration information loading... -
纯度
Immunogen affinity purified -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab122481于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度；实际最佳的稀释度/浓度应由使用者检定。
| 应用 | Ab评论 | 说明 |
|---|---|---|
| IHC-P |
1/20 - 1/50. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.
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| 说明 |
|---|
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IHC-P
1/20 - 1/50. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol. |
靶标
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序列相似性
Contains 1 OTU domain. - Information by UniProt
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数据库链接
- Entrez Gene: 220213 Human
- Entrez Gene: 71198 Mouse
- Entrez Gene: 498803 Rat
- Omim: 612022 Human
- SwissProt: Q5VV17 Human
- SwissProt: Q9CUB6 Mouse
- Unigene: 499042 Human
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别名
- DUBA-7 antibody
- DUBA7 antibody
- OTDC1 antibody
see all
图片
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-OTUD1 antibody (ab122481)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of lung tissue labelling OTUD1 with ab122481 at 1/50 dilution. Heat mediated antigen retrieval performed with citrate buffer pH 6 before commencing with IHC staining protocol.
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-OTUD1 antibody (ab122481)Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of lymph node tissue labelling OTUD1 with ab122481 at 1/50 dilution. Heat mediated antigen retrieval performed with citrate buffer pH 6 before commencing with IHC staining protocol.
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-OTUD1 antibody (ab122481)Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of duodenum tissue labelling OTUD1 with ab122481 at 1/50 dilution. Heat mediated antigen retrieval performed with citrate buffer pH 6 before commencing with IHC staining protocol.
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-OTUD1 antibody (ab122481)Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of liver tissue labelling OTUD1 with ab122481 at 1/50 dilution. Heat mediated antigen retrieval performed with citrate buffer pH 6 before commencing with IHC staining protocol.
实验方案
数据表及文件
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SDS download
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Datasheet download
文献 (11)
ab122481 被引用在 11 文献中.
- Zhang Q et al. VE-822 upregulates the deubiquitinase OTUD1 to stabilize FHL1 to inhibit the progression of lung adenocarcinoma. Cell Oncol (Dordr) 46:1001-1014 (2023). PubMed: 36929488
- Ma X et al. The deubiquitinase OTUD1 inhibits non-small cell lung cancer progression by deubiquitinating and stabilizing KLF4. Thorac Cancer 13:761-770 (2022). PubMed: 35098684
- Zhang HG et al. Depression compromises antiviral innate immunity via the AVP-AHI1-Tyk2 axis. Cell Res 32:897-913 (2022). PubMed: 35821088
- Snaurova R et al. Deubiquitinase OTUD1 Resolves Stalled Translation on polyA and Rare Codon Rich mRNAs. Mol Cell Biol 42:e0026522 (2022). PubMed: 36445135
- Luo Q et al. OTUD1 Activates Caspase-Independent and Caspase-Dependent Apoptosis by Promoting AIF Nuclear Translocation and MCL1 Degradation. Adv Sci (Weinh) 8:2002874 (2021). PubMed: 33898171