Anti-Osteoprotegerin抗体(ab183910)
Key features and details
- Rabbit polyclonal to Osteoprotegerin
- Suitable for: WB, IHC-P
- Reacts with: Mouse, Human
- Isotype: IgG
选择批间可重复性更高的重组抗体
- 研究可靠 —— 各批次间结果一致且可重复
- 长期批量供应 —— 采用重组技术,可实现快速生产
- 首次实验即可成功 —— 经过大量验证确认了特异性
- 符合伦理标准 —— 产品不含动物成分
概述
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产品名称
Anti-Osteoprotegerin抗体
参阅全部 Osteoprotegerin 一抗 -
描述
兔多克隆抗体to Osteoprotegerin -
宿主
Rabbit -
经测试应用
适用于: WB, IHC-Pmore details -
种属反应性
与反应: Mouse, Human -
免疫原
Synthetic peptide within Human Osteoprotegerin aa 1-67. The exact sequence is proprietary.
Database link: O00300 -
阳性对照
- Raji whole cell lysate; Mouse heart lysate; Cal27 xenograft.
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常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle. -
存储溶液
pH: 7.00
Preservative: 0.025% Proclin 300
Constituents: 79% PBS, 20% Glycerol (glycerin, glycerine) -
Concentration information loading...
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纯度
Immunogen affinity purified -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
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Positive Controls
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab183910于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度;实际最佳的稀释度/浓度应由使用者检定。
应用 | Ab评论 | 说明 |
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WB |
1/500 - 1/3000. Predicted molecular weight: 46 kDa.
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IHC-P |
1/100 - 1/1000.
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说明 |
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WB
1/500 - 1/3000. Predicted molecular weight: 46 kDa. |
IHC-P
1/100 - 1/1000. |
靶标
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功能
Acts as decoy receptor for RANKL and thereby neutralizes its function in osteoclastogenesis. Inhibits the activation of osteoclasts and promotes osteoclast apoptosis in vitro. Bone homeostasis seems to depend on the local RANKL/OPG ratio. May also play a role in preventing arterial calcification. May act as decoy receptor for TRAIL and protect against apoptosis. TRAIL binding blocks the inhibition of osteoclastogenesis. -
组织特异性
Highly expressed in adult lung, heart, kidney, liver, spleen, thymus, prostate, ovary, small intestine, thyroid, lymph node, trachea, adrenal gland, testis, and bone marrow. Detected at very low levels in brain, placenta and skeletal muscle. Highly expressed in fetal kidney, liver and lung. -
疾病相关
Defects in TNFRSF11B are the cause of juvenile Paget disease (JPD) [MIM:239000]; also known as hyperostosis corticalis deformans juvenilis or hereditary hyperphosphatasia or chronic congenital idiopathic hyperphosphatasia. JPD is a rare autosomal recessive osteopathy that presents in infancy or early childhood. The disorder is characterized by rapidly remodeling woven bone, osteopenia, debilitating fractures, and deformities due to a markedly accelerated rate of bone remodeling throughout the skeleton. Approximately 40 cases of JPD have been reported worldwide. Unless it is treated with drugs that block osteoclast-mediated skeletal resorption, the disease can be fatal. -
序列相似性
Contains 2 death domains.
Contains 4 TNFR-Cys repeats. -
翻译后修饰
N-glycosylated. Contains sialic acid residues.
The N-terminus is blocked. -
细胞定位
Secreted. - Information by UniProt
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数据库链接
- Entrez Gene: 4982 Human
- Entrez Gene: 18383 Mouse
- Omim: 602643 Human
- SwissProt: O00300 Human
- SwissProt: O08712 Mouse
- Unigene: 81791 Human
- Unigene: 15383 Mouse
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别名
- MGC29565 antibody
- OCIF antibody
- OPG antibody
see all
图片
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Immunohistochemical analysis of paraffin-embedded Cal27 xenograft labeling OPG with ab183910 at 1/500 dilution. Antigen Retrieval: EDTA based buffer, pH 8.0 for 15 min.
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Anti-Osteoprotegerin antibody (ab183910) at 1/1000 dilution + Mouse heart lysate at 50 µg
Predicted band size: 46 kDa10% SDS-PAGE
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Anti-Osteoprotegerin antibody (ab183910) at 1/1000 dilution + Raji whole cell lysate at 30 µg
Predicted band size: 46 kDa10% SDS-PAGE
数据表及文件
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SDS download
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Datasheet download
文献 (31)
ab183910 被引用在 31 文献中.
- Kisielowski K et al. Prognostic relevance of clinicopathological factors in sporadic and syndromic odontogenic keratocysts: A comparative study. Adv Clin Exp Med 32:245-259 (2023). PubMed: 36226690
- Tang LD et al. Iridoid from Eucommia ulmoides Oliv. Exerts Antiarthritis Effects by Inhibiting the JAK2/STAT3 Signaling Pathway In Vivo and In Vitro. Evid Based Complement Alternat Med 2023:4167906 (2023). PubMed: 37123081
- Lv H et al. A static magnetic field improves bone quality and balances the function of bone cells with regulation on iron metabolism and redox status in type 1 diabetes. FASEB J 37:e22985 (2023). PubMed: 37249350
- de Kort WWB et al. Jaw Bone Invasion of Oral Squamous Cell Carcinoma Is Associated with Osteoclast Count and Expression of Its Regulating Proteins in Patients and Organoids. J Clin Med 12:N/A (2023). PubMed: 37762975
- Yu X et al. LncRNA SNHG1 modulates adipogenic differentiation of BMSCs by promoting DNMT1 mediated Opg hypermethylation via interacting with PTBP1. J Cell Mol Med 26:60-74 (2022). PubMed: 34854215