AB97395

Anti-Ornithine Decarboxylase/ODC 抗体

Name: Ornithine Decarboxylase/ODC抗体 (ab97395)| Abcam中文官网
Brand: Abcam Limited
SKU: AB97395
Price: 4413 CNY
Availability: InStock

Anti-Ornithine Decarboxylase/ODC antibody

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(18 Publications)

Anti-Ornithine Decarboxylase/ODC antibody (ab97395) is a rabbit polyclonal antibody detecting Ornithine Decarboxylase/ODC in Western Blot, IHC-P. Suitable for Human, Mouse, Rat.

- Over 10 publications
- Trusted since 2010

查看别名

Ornithine decarboxylase, ODC, ODC1

2 Images

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Ornithine Decarboxylase/ODC antibody (AB97395)

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Ornithine Decarboxylase/ODC antibody (AB97395)

Paraffin embedded mouse heart tissue stained for ODC using ab97395 at 1/1000 dilution in immunohistochemical analysis.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Ornithine Decarboxylase/ODC antibody (AB97395)

Paraffin embedded rat adrenal gland tissue stained for ODC using ab97395 at 1/500 dilution in immunohistochemical analysis.

关键信息

宿主种属

Rabbit

克隆

Polyclonal

亚型

IgG

不含载体蛋白

反应种属

Human, Mouse, Rat

应用

WB, IHC-P

applications

免疫原

Recombinant Fragment Protein within Human ODC1 aa 150-450. The exact immunogen used to generate this antibody is proprietary information.

P11926

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000", "WB-species-notes": "", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Mouse": { "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/100 - 1/1000", "IHCP-species-notes": "" }, "Rat": { "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/100 - 1/1000", "IHCP-species-notes": "" }, "Cow": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Pig": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }

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产品详情

What is this antibody validated in?
Anti-Ornithine Decarboxylase/ODC antibody (ab97395) is a rabbit polyclonal antibody and is validated for use in Western Blot (WB), Immunohistochemistry (IHC-P) in Human, Mouse, Rat samples.

What is the molecular weight of Ornithine Decarboxylase/ODC?
Anti-Ornithine Decarboxylase/ODC (ab97395) specifically detects a band for Ornithine Decarboxylase/ODC (UniProt: P11926) at a molecular weight of 51kDa.

Trusted by the scientific community
Anti-Ornithine Decarboxylase/ODC (ab97395) was first used in a scientific publication in 2010 and has been cited over 10 times in peer-reviewed journals.

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性能和储存信息

形式

Liquid

纯化工艺

Affinity purification Immunogen

存储溶液

pH: 7 Preservative: 0.025% Proclin 300 Constituents: PBS, 20% Glycerol (glycerin, glycerine)

运输条件

Blue Ice

分装信息

Upon delivery aliquot

储存信息

Avoid freeze / thaw cycle

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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

Ornithine Decarboxylase also known as ODC or ODC1 is an enzyme that plays an important role in polyamine biosynthesis. This enzyme catalyzes the decarboxylation of ornithine to form putrescine a precursor for spermidine and spermine. ODC is a small protein with a molecular mass around 48 kDa. It is expressed in various tissues including the liver kidney and brain. ODC expression tends to be highest in rapidly growing tissues due to its involvement in cell growth and differentiation.

Biological function summary

ODC actively participates in cell proliferation and differentiation by regulating the levels of polyamines which are essential for DNA stabilization and cellular processes. While ODC does not form part of a larger protein complex its activity requires the presence of cofactor pyridoxal 5'-phosphate. By controlling polyamine synthesis ODC influences gene expression ion channel functions and protein synthesis impacting cell cycle progression and apoptosis.

Pathways

Ornithine decarboxylation connects with important biological processes such as the urea cycle and polyamine biosynthetic pathway. In these pathways enzymes like arginase and S-adenosylmethionine decarboxylase work closely with ODC. ODC's role in regulating polyamine levels makes it an important component of cellular metabolism and growth pathways. Through these pathways ODC coordinates with other proteins to ensure proper cellular function and response to growth signals.

ODC activity has been linked to cancer and neurological disorders. Overexpression and dysregulation of ODC can lead to increased polyamine levels which associate with tumor development and proliferation particularly in colorectal cancer. ODC also connects with proteins like c-Myc which regulates its expression and is often dysregulated in cancer. In neurological disorders abnormal ODC function affects neurodegeneration influencing proteins involved in neuronal survival and plasticity.

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产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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靶点信息

Catalyzes the first and rate-limiting step of polyamine biosynthesis that converts ornithine into putrescine, which is the precursor for the polyamines, spermidine and spermine. Polyamines are essential for cell proliferation and are implicated in cellular processes, ranging from DNA replication to apoptosis.

See full target information ODC1

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文献 (18)

Recent publications for all applications. Explore the full list and refine your search

Infection and immunity 91:e0023623 PubMed37861311

2023

Polyamines and hypusination are important for toxin B (TcdB)-mediated activation of group 3 innate lymphocytes (ILC3s).

Applications

Unspecified application

Species

Unspecified reactive species

Prakash Sah,Bailey A Knighten,Megan A Reidy,Lauren A Zenewicz

ImmunoHorizons 7:41-48 PubMed36637514

2023

The Polyamine Putrescine Is a Positive Regulator of Group 3 Innate Lymphocyte Activation.

Applications

Unspecified application

Species

Unspecified reactive species

Prakash Sah,Lauren A Zenewicz

Journal of enzyme inhibition and medicinal chemistry 38:309-318 PubMed36451618

2022

DMSO-tolerant ornithine decarboxylase (ODC) tandem assay optimised for high-throughput screening.

Applications

Unspecified application

Species

Unspecified reactive species

Mingu Gordon Park,Suyeon Yellena Kim,C Justin Lee

Cell & bioscience 12:183 PubMed36371321

2022

mTORC1-c-Myc pathway rewires methionine metabolism for HCC progression through suppressing SIRT4 mediated ADP ribosylation of MAT2A.

Applications

Unspecified application

Species

Unspecified reactive species

Liang Zhao,Huizhao Su,Xiaomeng Liu,Hongquan Wang,Yukuan Feng,Yan Wang,Haiqiang Chen,Luo Dai,Shihui Lai,Siqi Xu,Chong Li,Jihui Hao,Bo Tang

Cancer gene therapy 29:940-950 PubMed34522028

2021

The biguanide polyamine analog verlindamycin promotes differentiation in neuroblastoma via induction of antizyme.

Applications

Unspecified application

Species

Unspecified reactive species

Zuzanna Urban-Wójciuk,Amy Graham,Karen Barker,Colin Kwok,Yordan Sbirkov,Louise Howell,James Campbell,Patrick M Woster,Evon Poon,Kevin Petrie,Louis Chesler

Cell 184:4186-4202.e20 PubMed34216540

2021

Polyamine metabolism is a central determinant of helper T cell lineage fidelity.

Applications

Unspecified application

Species

Unspecified reactive species

Daniel J Puleston,Francesc Baixauli,David E Sanin,Joy Edwards-Hicks,Matteo Villa,Agnieszka M Kabat,Marcin M Kamiński,Michal Stanckzak,Hauke J Weiss,Katarzyna M Grzes,Klara Piletic,Cameron S Field,Mauro Corrado,Fabian Haessler,Chao Wang,Yaarub Musa,Lena Schimmelpfennig,Lea Flachsmann,Gerhard Mittler,Nir Yosef,Vijay K Kuchroo,Joerg M Buescher,Stefan Balabanov,Edward J Pearce,Douglas R Green,Erika L Pearce

Journal of animal science and biotechnology 12:46 PubMed33827696

2021

Pre-implantation exogenous progesterone and pregnancy in sheep. II. Effects on fetal-placental development and nutrient transporters in late pregnancy.

Applications

Unspecified application

Species

Unspecified reactive species

Katherine M Halloran,Emily C Hoskins,Claire Stenhouse,Robyn M Moses,Kathrin A Dunlap,M Carey Satterfield,Heewon Seo,Gregory A Johnson,Guoyao Wu,Fuller W Bazer

Molecules (Basel, Switzerland) 26: PubMed33915902

2021

Metformin Inhibits the Urea Cycle and Reduces Putrescine Generation in Colorectal Cancer Cell Lines.

Applications

Unspecified application

Species

Unspecified reactive species

Tao Zhang,Ling Hu,Jia-Feng Tang,Hang Xu,Kuan Tian,Meng-Na Wu,Shi-Ying Huang,Yu-Mei Du,Peng Zhou,Rui-Jin Lu,Shuang He,Jia-Mei Xu,Jian-Jun Si,Jing Li,Di-Long Chen,Jian-Hua Ran

Journal of animal science and biotechnology 12:39 PubMed33663606

2021

Pre-implantation exogenous progesterone and pregnancy in sheep: I. polyamines, nutrient transport, and progestamedins.

Applications

Unspecified application

Species

Unspecified reactive species

Emily C Hoskins,Katherine M Halloran,Claire Stenhouse,Robyn M Moses,Kathrin A Dunlap,Michael C Satterfield,Heewon Seo,Gregory A Johnson,Guoyao Wu,Fuller W Bazer

International journal of molecular medicine 47: PubMed33537831

2021

Exogenous spermine attenuates diabetic kidney injury in rats by inhibiting AMPK/mTOR signaling pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Xinying Zhang,Li Zhang,Zhe Chen,Siwei Li,Bingbing Che,Ningning Wang,Junting Chen,Changqing Xu,Can Wei

View all publications

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Anti-Ornithine Decarboxylase/ODC 抗体

Anti-Ornithine Decarboxylase/ODC antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Ornithine Decarboxylase/ODC antibody (AB97395)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Ornithine Decarboxylase/ODC antibody (AB97395)

关键信息

宿主种属

克隆

亚型

不含载体蛋白

反应种属

应用

免疫原

反应性数据

产品详情

性能和储存信息

形式

纯化工艺

存储溶液

运输条件

推荐的短期储存时间

推荐的短期储存条件

推荐的长期储存条件

分装信息

储存信息

补充信息

Biological function summary

Pathways

产品实验方案

靶点信息

文献 (18)

Abcam Product Promise

Anti-Ornithine Decarboxylase/ODC 抗体

Anti-Ornithine Decarboxylase/ODC antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Ornithine Decarboxylase/ODC antibody (AB97395)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Ornithine Decarboxylase/ODC antibody (AB97395)

关键信息

宿主种属

克隆

亚型

不含载体蛋白

反应种属

应用

免疫原

替代产品

Primary Antibodies

Primary Antibodies

Primary Antibodies

搭配使用产品

Primary Antibodies

Primary Antibodies

Primary Antibodies

Primary Antibodies

反应性数据

产品详情

性能和储存信息

形式

纯化工艺

存储溶液

运输条件

推荐的短期储存时间

推荐的短期储存条件

推荐的长期储存条件

分装信息

储存信息

补充信息

Biological function summary

Pathways

产品实验方案

靶点信息

文献 (18)

Abcam Product Promise