Anti-Orexin Receptor 1 and 2抗体(ab77370)
Key features and details
- Goat polyclonal to Orexin Receptor 1 and 2
- Suitable for: WB
- Reacts with: Human
- Isotype: IgG
概述
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产品名称
Anti-Orexin Receptor 1 and 2抗体 -
描述
山羊多克隆抗体to Orexin Receptor 1 and 2 -
宿主
Goat -
经测试应用
适用于: WBmore details -
种属反应性
与反应: Human
预测可用于: Chicken, Cow, Dog, Pig, Zebrafish
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免疫原
Synthetic peptide. This information is proprietary to Abcam and/or its suppliers.
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常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle. -
存储溶液
pH: 7.30
Preservative: 0.02% Sodium azide
Constituents: 0.5% BSA, Tris buffered saline -
Concentration information loading... -
纯度
Immunogen affinity purified -
纯化说明
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
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Positive Controls
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab77370于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度；实际最佳的稀释度/浓度应由使用者检定。
| 应用 | Ab评论 | 说明 |
|---|---|---|
| WB |
Use a concentration of 0.3 - 1 µg/ml. Detects a band of approximately 49 kDa (predicted molecular weight: 49 kDa).
1 hour primary incubation is recommended for this product. |
| 说明 |
|---|
|
WB
Use a concentration of 0.3 - 1 µg/ml. Detects a band of approximately 49 kDa (predicted molecular weight: 49 kDa). 1 hour primary incubation is recommended for this product. |
靶标
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相关性
Orexins, also called hypocretins, are the common names given to a pair of highly excitatory neuropeptide hormones that were simultaneously discovered by two groups of reseachers in rat brains. The two highly related peptides (orexin A and B, or hypocretin 1 and 2) are produced by cleavage of a single precursor protein. Studies suggest that orexin A/hypocretin 1 may be of greater biological importance than orexin B/hypocretin 2. Although these peptides are produced by a very small population of cells in the lateral and posterior hypothalamus, they send projections throughout the brain. The orexins/hypocretins are strongly conserved peptides, found in all major classes of vertebrates. The peptides are thought to have arisen early in vertebrate evolution. -
细胞定位
Membrane; multi pass membrane protein. -
数据库链接
- Entrez Gene: 428644 Chicken
- Entrez Gene: 282248 Cow
- Entrez Gene: 399545 Dog
- Entrez Gene: 3061 Human
- Entrez Gene: 3062 Human
- Entrez Gene: 387287 Pig
- Entrez Gene: 397428 Pig
- Entrez Gene: 378447 Zebrafish
see all -
别名
- CD200R antibody
- HCRTR1 antibody
- HCRTR2 antibody
see all
图片
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Western blot - Anti-Orexin Receptor 1 and 2 antibody (ab77370)Anti-Orexin Receptor 1 and 2 antibody (ab77370) at 0.5 µg/ml + human frontal cortex lysate in RIPA buffer at 35 µg
Developed using the ECL technique.
Predicted band size: 49 kDa
Observed band size: 49 kDa
数据表及文件
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Datasheet download
文献 (2)
ab77370 被引用在 2 文献中.
- Cao XL et al. Chaihu-Longgu-Muli decoction improves sleep disorders by restoring orexin-A function in CKD mice. Front Endocrinol (Lausanne) 14:1206353 (2023). PubMed: 37441503
- Liu Z et al. Amyloid ß and tau are involved in sleep disorder in Alzheimer's disease by orexin A and adenosine A(1) receptor. Int J Mol Med 43:435-442 (2019). PubMed: 30365112
