Anti-OPN3抗体

靶点信息

G-protein coupled receptor which selectively activates G proteins via ultraviolet A (UVA) light-mediated activation in the skin (PubMed : 28842328, PubMed : 31097585, PubMed : 31380578). Binds both 11-cis retinal and all-trans retinal (PubMed : 31097585). Regulates melanogenesis in melanocytes via inhibition of alpha-MSH-induced MC1R-mediated cAMP signaling, modulation of calcium flux, regulation of CAMK2 phosphorylation, and subsequently phosphorylation of CREB, p38, ERK and MITF in response to blue light (PubMed : 28842328, PubMed : 31097585). Plays a role in melanocyte survival through regulation of intracellular calcium levels and subsequent BCL2/RAF1 signaling (PubMed : 31730232). Additionally regulates apoptosis via cytochrome c release and subsequent activation of the caspase cascade (PubMed : 31730232). Required for TYR and DCT blue light-induced complex formation in melanocytes (PubMed : 28842328). Involved in keratinocyte differentiation in response to blue-light (PubMed : 30168605). Required for the UVA-mediated induction of calcium and mitogen-activated protein kinase signaling resulting in the expression of MMP1, MMP2, MMP3, MMP9 and TIMP1 in dermal fibroblasts (PubMed : 31380578). Plays a role in light-mediated glucose uptake, mitochondrial respiration and fatty acid metabolism in brown adipocyte tissues (By similarity). May be involved in photorelaxation of airway smooth muscle cells, via blue-light dependent GPCR signaling pathways (By similarity).