Anti-Ogg1抗体(ab62826)
Key features and details
- Goat polyclonal to Ogg1
- Suitable for: WB
- Reacts with: Rat
- Isotype: IgG
概述
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产品名称
Anti-Ogg1抗体
参阅全部 Ogg1 一抗 -
描述
山羊多克隆抗体to Ogg1 -
宿主
Goat -
经测试应用
适用于: WBmore details -
种属反应性
与反应: Rat
预测可用于: Mouse, Cow, Human
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免疫原
Synthetic peptide:
C-HPKTSQAKGPSPLANK
, corresponding to internal sequence amino acids 282-297 of Rat Ogg1 -
阳性对照
- Rat Spleen lysate
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常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. -
存储溶液
pH: 7.30
Preservative: 0.02% Sodium azide
Constituents: Tris buffered saline, 0.5% BSA -
Concentration information loading... -
纯度
Immunogen affinity purified -
纯化说明
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
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Recombinant Protein
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab62826于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度；实际最佳的稀释度/浓度应由使用者检定。
| 应用 | Ab评论 | 说明 |
|---|---|---|
| WB | (3) |
Use a concentration of 0.1 - 0.3 µg/ml. Detects a band of approximately 37 kDa (predicted molecular weight: 39 kDa).
1 hour primary incubation is recommended for this product. |
| 说明 |
|---|
|
WB
Use a concentration of 0.1 - 0.3 µg/ml. Detects a band of approximately 37 kDa (predicted molecular weight: 39 kDa). 1 hour primary incubation is recommended for this product. |
靶标
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功能
DNA repair enzyme that incises DNA at 8-oxoG residues. Excises 7,8-dihydro-8-oxoguanine and 2,6-diamino-4-hydroxy-5-N-methylformamidopyrimidine (FAPY) from damaged DNA. Has a beta-lyase activity that nicks DNA 3' to the lesion. -
组织特异性
Ubiquitous. -
疾病相关
Defects in OGG1 may be a cause of renal cell carcinoma (RCC) [MIM:144700]. It is a heterogeneous group of sporadic or hereditary carcinoma derived from cells of the proximal renal tubular epithelium. It is subclassified into clear cell renal carcinoma (non-papillary carcinoma), papillary renal cell carcinoma, chromophobe renal cell carcinoma, collecting duct carcinoma with medullary carcinoma of the kidney, and unclassified renal cell carcinoma. -
序列相似性
Belongs to the type-1 OGG1 family. -
细胞定位
Mitochondrion; Nucleus and Nucleus > nucleoplasm. Nucleus speckle. Nucleus matrix. Together with APEX1 is recruited to nuclear speckles in UVA-irradiated cells. - Information by UniProt
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数据库链接
- Entrez Gene: 4968 Human
- Entrez Gene: 18294 Mouse
- Entrez Gene: 81528 Rat
- Omim: 601982 Human
- SwissProt: O15527 Human
- SwissProt: O08760 Mouse
- SwissProt: O70249 Rat
- Unigene: 380271 Human
see all -
别名
- 8 hydroxyguanine DNA glycosylase antibody
- 8 oxoguanine DNA glycosylase 1 antibody
- 8 oxoguanine DNA glycosylase antibody
see all
图片
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Western blot - Anti-Ogg1 antibody (ab62826)Anti-Ogg1 antibody (ab62826) at 0.1 µg/ml + Rat Spleen lysate at 35 µg
Predicted band size: 39 kDa
Observed band size: 37 kDa why is the actual band size different from the predicted?
Detected by chemiluminescence
数据表及文件
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Datasheet download
文献 (1)
ab62826 被引用在 1 文献中.
- Sun X et al. Mitochondrial transplantation ameliorates doxorubicin-induced cardiac dysfunction via activating glutamine metabolism. iScience 26:107790 (2023). WB ; Human . PubMed: 37731615
