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AB121797

Anti-NXT2抗体

Anti-NXT2 antibody

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(2 Publications)

Rabbit Polyclonal NXT2 antibody. Suitable for IHC-P, WB and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human NXT2 aa 1 to C-terminus.

查看别名

BM-025, DC9, NXT2, NTF2-related export protein 2, Protein p15-2

2 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-NXT2 antibody (AB121797)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-NXT2 antibody (AB121797)

ab121797, at 1/450 dilution, staining NXT2 in paraffin-embedded Human pancreas tissue, by Immunohistochemistry.

Western blot - Anti-NXT2 antibody (AB121797)
  • WB

Unknown

Western blot - Anti-NXT2 antibody (AB121797)

All lanes:

Western blot - Anti-NXT2 antibody (ab121797) at 1/250 dilution

Lane 1:

Negative control (Vector-only transfected HEK293T lysate).

Lane 2:

NXT2-transfected HEK293T Over-expression Lysate (Co-expressed with a C-terminal myc-DDK tag (~3.1 kDa))

Predicted band size: 16 kDa

true

关键信息

宿主种属

Rabbit

克隆

Polyclonal

亚型

IgG

不含载体蛋白

No

反应种属

Human

应用

WB, IHC-P

applications

免疫原

Recombinant Fragment Protein within Human NXT2 aa 1 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

Q9NPJ8

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/200 - 1/500", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.04-0.4 µg/mL", "WB-species-notes": "<p></p>" } } }
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性能和储存信息

形式
Liquid
纯化工艺
Affinity purification Immunogen
存储溶液
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
运输条件
Blue Ice
推荐的短期储存条件
+4°C
推荐的长期储存条件
-20°C
分装信息
Upon delivery aliquot
储存信息
Avoid freeze / thaw cycle
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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

NXT2 also known as NTF2-like export factor 2 plays a role in nuclear transport. This protein has a molecular mass of approximately 14 kDa. It is expressed in a variety of tissues primarily in the nucleus where it functions in the export of RNA from the nucleus to the cytoplasm. The protein's mechanical action facilitates the translocation of mRNA and tRNA substrates across the nuclear envelope an essential step in gene expression regulation.
Biological function summary

NXT2 is involved in the transport machinery where it associates with nuclear export complexes. It interacts with other proteins like NXF1 to function as a part of the mRNA export pathway. The presence of NXT2 in these export complexes highlights its necessity in post-transcriptional regulation. This role emphasizes its significance in maintaining cellular function by ensuring that mRNA is correctly moved to the cytoplasm for translation.

Pathways

NXT2 has essential roles in the mRNA nuclear export pathway and is also linked to the tRNA export pathway. These pathways are important for proper gene expression and protein synthesis. NXT2 interacts closely with proteins such as NXF1 and other nucleoporins acting as an important component in these pathways. Its role in these processes hints at its broader implications in cellular signaling and adaptation directly influencing how cells respond to environmental and developmental cues.

Alterations in NXT2 function can relate to cancer and neurodegenerative disorders. Abnormal NXT2 activity may disrupt RNA export leading to uncontrolled cell growth or impaired neuronal function. NXT2's relationship with proteins involved in these diseases such as NXF1 in the case of cancer highlights its importance in disease pathology. These connections point to NXT2 as a potential target for therapeutic intervention opening avenues for more precise treatment strategies.
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产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:
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靶点信息

Regulator of protein export for NES-containing proteins. Also plays a role in mRNA nuclear export.
See full target information NXT2
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文献 (2)

Recent publications for all applications. Explore the full list and refine your search

Cancer discovery 11:2282-2299 PubMed33883167

2021

Selective Modulation of a Pan-Essential Protein as a Therapeutic Strategy in Cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Clare F Malone,Neekesh V Dharia,Guillaume Kugener,Alexandra B Forman,Michael V Rothberg,Mai Abdusamad,Alfredo Gonzalez,Miljan Kuljanin,Amanda L Robichaud,Amy Saur Conway,Joshua M Dempster,Brenton R Paolella,Nancy Dumont,Volker Hovestadt,Joseph D Mancias,Scott T Younger,David E Root,Todd R Golub,Francisca Vazquez,Kimberly Stegmaier

Molecular biology of the cell 24:42-55 PubMed23135998

2012

MicroRNA-7-regulated TLR9 signaling-enhanced growth and metastatic potential of human lung cancer cells by altering the phosphoinositide-3-kinase, regulatory subunit 3/Akt pathway.

Applications

WB

Species

Unspecified reactive species

Lin Xu,Zhenke Wen,Ya Zhou,Zhongmin Liu,Qinchuan Li,Guangru Fei,Junmin Luo,Tao Ren
View all publications
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