AB168481

Anti-NXT1抗体

Name: NXT1抗体 (ab168481)| Abcam中文官网
Brand: Abcam Limited
SKU: AB168481
Price: 4744 CNY
Availability: InStock

Anti-NXT1 antibody

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(1 Publication)

Mouse Polyclonal NXT1 antibody. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human NXT1.

查看别名

NTF2-related export protein 1, Protein p15, NXT1

2 Images

Immunocytochemistry/ Immunofluorescence - Anti-NXT1 antibody (AB168481)

ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-NXT1 antibody (AB168481)

Immunofluorescent analysis of HeLa cells labeling NXT1 with ab168481 at 10 µg/ml.

Unknown

Western blot - Anti-NXT1 antibody (AB168481)

All lanes:

Western blot - Anti-NXT1 antibody (ab168481) at 1 µg/mL

Lane 1:

NXT1 transfected 293T cell lysate at 15 µL

Lane 2:

Non-transfected 293T cell lysate at 15 µL

Predicted band size: 15 kDa

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关键信息

宿主种属

Mouse

克隆

Polyclonal

亚型

IgG

不含载体蛋白

反应种属

Human

应用

ICC/IF, WB

applications

免疫原

Recombinant Full Length Protein corresponding to Human NXT1.

Q9UKK6

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1 µg/mL", "WB-species-notes": "<p></p>", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "10 µg/mL", "ICCIF-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Rat": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" } } }

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性能和储存信息

形式

Liquid

纯化工艺

Affinity purification Protein A

存储溶液

pH: 7.4 Constituents: PBS

运输条件

Blue Ice

分装信息

Upon delivery aliquot

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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

The NXT1 protein also known as NTX1 or nuclear export transporter factor 1 is an essential part of cellular machinery. It has a molecular weight of approximately 17 kDa. Expressed ubiquitously in human tissues NXT1 plays a significant role in nuclear transport processes. The protein forms a critical component of the nuclear export pathway primarily involved in the transport of RNA molecules between the nucleus and the cytoplasm. This function requires a complex interaction with nuclear export signals and other proteins involved in export mechanisms.

Biological function summary

NXT1 acts in coordination with exportin proteins as part of the nuclear export complex. It binds with the nuclear export receptor CRM1 to mediate the transport of RNA and proteins out of the nucleus. This interaction facilitates the shuttling of cargo molecules ensuring proper cellular function and gene expression regulation. By partnering with other export factors NXT1 helps maintain cellular homeostasis and is vital for proper cell cycle progression and signal transduction.

Pathways

Several transport and signaling pathways rely on NXT1's function. It plays a significant role in the nuclear export pathway ensuring the delivery of ribonucleoproteins and mRNA to the cytoplasm for translation. NXT1 interacts closely with other key proteins like CRM1 and RanGTP in this pathway emphasizing its role in cellular traffic control. Furthermore its involvement in the RNA processing pathway links it to broader regulatory networks essential for proper gene expression.

Defects in NXT1 functioning can lead to issues associated with disrupted RNA transport and gene regulation. Abnormalities in its pathway may contribute to the development of conditions like cancer where improper cell cycle regulation is observed. Additionally NXT1 dysfunction is linked to neurodegenerative disorders characterized by misregulated RNA export and protein synthesis. Connections with proteins such as CRM1 highlight the potential for targeted therapeutic approaches in addressing these ailments.

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产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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靶点信息

Stimulator of protein export for NES-containing proteins (PubMed : 10567585). Also plays a role in the nuclear export of U1 snRNA, tRNA, and mRNA (PubMed : 10848583). The NXF1-NXT1 heterodimer is involved in the export of HSP70 mRNA in conjunction with ALYREF/THOC4 and THOC5 (PubMed : 11259602, PubMed : 19165146).

See full target information NXT1

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文献 (1)

Recent publications for all applications. Explore the full list and refine your search

Acta biochimica Polonica 69:417-422 PubMed35696596

2022

USP18 contributes to the proliferation and migration of ovarian cancer cells by regulating the AKT/mTOR signaling pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Meiqin Liu,Shile Gao,Xingjun Xu,Lijie Zhang,Bin Xu,Donghui Lu

View all publications

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Anti-NXT1抗体

Anti-NXT1 antibody

Immunocytochemistry/ Immunofluorescence - Anti-NXT1 antibody (AB168481)

Western blot - Anti-NXT1 antibody (AB168481)