Anti-NUT抗体(ab122649)
Key features and details
- Rabbit polyclonal to NUT
- Suitable for: IHC-P
- Reacts with: Human
- Isotype: IgG
概述
-
产品名称
Anti-NUT抗体
参阅全部 NUT 一抗 -
描述
兔多克隆抗体to NUT -
宿主
Rabbit -
经测试应用
适用于: IHC-Pmore details -
种属反应性
与反应: Human -
免疫原
antigen sequence: TCPLNVHSYDPQGEGRVDPDLSKPKNLAPLQESQESYTTGTPKATSSHQG LGSTLPRRGT RNAIVPRETSVSKTHRSA, corresponding to amino acids 920-997 of Human NUT (Q86Y26).
-
阳性对照
- Human testis tissue
-
常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
-
形式
Liquid -
存放说明
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. -
存储溶液
pH: 7.20
Preservative: 0.02% Sodium azide
Constituents: 59% PBS, 40% Glycerol -
Concentration information loading... -
纯度
Immunogen affinity purified -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
-
Compatible Secondaries
-
Isotype control
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab122649于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度；实际最佳的稀释度/浓度应由使用者检定。
| 应用 | Ab评论 | 说明 |
|---|---|---|
| IHC-P |
1/500 - 1/1000. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.
|
| 说明 |
|---|
|
IHC-P
1/500 - 1/1000. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol. |
靶标
-
组织特异性
Specifically expressed in testis. -
疾病相关
Note=A chromosomal aberration involving NUT is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with BRD4 which produces a BRD4-NUT fusion protein.
Note=A chromosomal aberration involving NUT is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;9)(q14;q34) with BRD3 which produces a BRD3-NUT fusion protein. -
序列相似性
Belongs to the FAM22 family. -
翻译后修饰
Phosphorylation on Ser-1026, Ser-1029 or Ser-1031 is important for cytoplasmic export. -
细胞定位
Cytoplasm. Nucleus. Shuttles between nucleus and cytoplasm. - Information by UniProt
-
数据库链接
- Entrez Gene: 256646 Human
- Omim: 608963 Human
- SwissProt: Q86Y26 Human
- Unigene: 525769 Human
-
别名
- C15orf55 antibody
- Chromosome 15 open reading frame 55 antibody
- DKFZp434O192 antibody
see all
图片
-
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-NUT antibody (ab122649)
ab122649 (1/3000), staining NUT in paraffin embedded Human testis tissue by Immunohistochemistry.
-
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-NUT antibody (ab122649)ab122649 (1/3000), showing negative staining NUT in paraffin embedded Human endometrium tissue by Immunohistochemistry.
-
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-NUT antibody (ab122649)ab122649 (1/3000), showing negative staining NUT in paraffin embedded Human skeletal muscle tissue by Immunohistochemistry.
-
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-NUT antibody (ab122649)ab122649 (1/3000), showing negative staining NUT in paraffin embedded Human liver tissue by Immunohistochemistry.
数据表及文件
-
SDS download
-
Datasheet download
文献 (2)
ab122649 被引用在 2 文献中.
- Yang S et al. CIC-NUTM1 Sarcomas Affecting the Spine. Arch Pathol Lab Med 146:735-741 (2022). PubMed: 34525172
- Zhou L et al. Clinicopathological Analysis of Five Cases of NUT Midline Carcinoma, including One with the Gingiva. Biomed Res Int 2020:9791208 (2020). PubMed: 32149149