Anti-Nurr1抗体(ab176184)
Key features and details
- Rabbit polyclonal to Nurr1
- Suitable for: WB, IHC-P
- Reacts with: Mouse
- Isotype: IgG
概述
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产品名称
Anti-Nurr1抗体
参阅全部 Nurr1 一抗 -
描述
兔多克隆抗体to Nurr1 -
宿主
Rabbit -
经测试应用
适用于: WB, IHC-Pmore details -
种属反应性
与反应: Mouse -
免疫原
Synthetic peptide within Human Nurr1 aa 566-591. The exact sequence is proprietary. The selected peptide was post-synthetically modified to achieve highest antigenicity before coupling to carrier protein using hetero bifunctional cross linker.
Sequence:CTQGLQRIFYLKLEDLVPPPAIIDKL
Database link: P43354 -
常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle. -
存储溶液
Preservative: 0.02% Sodium azide -
Concentration information loading... -
纯度
Immunogen affinity purified -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
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Recombinant Protein
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab176184于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度；实际最佳的稀释度/浓度应由使用者检定。
| 应用 | Ab评论 | 说明 |
|---|---|---|
| WB |
1/500. Detects a band of approximately 75 kDa (predicted molecular weight: 67 kDa).
|
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| IHC-P |
1/50 - 1/100.
|
| 说明 |
|---|
|
WB
1/500. Detects a band of approximately 75 kDa (predicted molecular weight: 67 kDa). |
|
IHC-P
1/50 - 1/100. |
靶标
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功能
Transcriptional regulator which is important for the differentiation and maintenance of meso-diencephalic dopaminergic (mdDA) neurons during development. It is crucial for expression of a set of genes such as SLC6A3, SLC18A2, TH and DRD2 which are essential for development of mdDA neurons. -
组织特异性
Expressed in a number of cell lines of T-cell, B-cell and fibroblast origin. Strong expression in brain tissue. -
序列相似性
Belongs to the nuclear hormone receptor family. NR4 subfamily.
Contains 1 nuclear receptor DNA-binding domain. -
发展阶段
Rapidly and only very transiently expressed after cell activation, during the G0-G1 transition of the cell cycle. -
细胞定位
Nucleus. - Information by UniProt
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数据库链接
- Entrez Gene: 18227 Mouse
- SwissProt: Q06219 Mouse
- Unigene: 3507 Mouse
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别名
- HZF 3 antibody
- HZF3 antibody
- Immediate-early response protein NOT antibody
see all
图片
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Nurr1 antibody (ab176184)
Formalin-fixed, paraffin-embedded mouse kidney tissue stained for Nurr1 using ab176184 at 1:50 dilution (IHC Blocking Buffer) in immunohistochemical analysis. Hematoxylin QS (blue) was used to cunterstain.
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Western blot - Anti-Nurr1 antibody (ab176184)All lanes : Anti-Nurr1 antibody (ab176184) at 1/500 dilution
Lane 1 : Mouse skeletal muscle tissue lysate
Lane 2 : Mouse heart tissue lysate
Lane 3 : Mouse liver tissue lysate
Lane 4 : Mouse kidney tissue lysate
Lane 5 : Mouse lung tissue lysate
Lane 6 : Mouse large intestine tissue lysate
Lane 7 : Mouse small intestine tissue lysate
Lane 8 : Mouse spleen tissue lysate
Lane 9 : Mouse ovary tissue lysate
Lane 10 : Mouse bladder tissue lysate
Lane 11 : Mouse cerebellum tissue lysate
Lane 12 : Mouse spinal cord tissue lysate
Lane 13 : Mouse brain tissue lysate
Predicted band size: 67 kDa -
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Nurr1 antibody (ab176184)Formalin-fixed, paraffin-embedded mouse kidney tissue stained for Nurr1 using ab176184 at 1:50 dilution (IHC Blocking Buffer) in immunohistochemical analysis. Hematoxylin QS (blue) was used to cunterstain.
数据表及文件
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SDS download
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Datasheet download
文献 (3)
ab176184 被引用在 3 文献中.
- Ye Z et al. Targeting Microglial Metabolic Rewiring Synergizes with Immune-Checkpoint Blockade Therapy for Glioblastoma. Cancer Discov 13:974-1001 (2023). PubMed: 36649564
- Liu J et al. The Pathology of Morphine-Inhibited Nerve Repair and Morphine-Induced Nerve Damage Is Mediated via Endoplasmic Reticulum Stress. Front Neurosci 15:618190 (2021). PubMed: 33679302
- Hu L et al. Exosomal miR-409-3p secreted from activated mast cells promotes microglial migration, activation and neuroinflammation by targeting Nr4a2 to activate the NF-?B pathway. J Neuroinflammation 18:68 (2021). PubMed: 33750404