Anti-Nurr1抗体[447C2a] (ab54366)
![Western blot - Anti-Nurr1 antibody [447C2a] (ab54366)](https://www.abcam.cn/ps/products/54/ab54366/Images/ab54366.gif "Western blot - Anti-Nurr1 antibody [447C2a] (ab54366)")
Key features and details
- Mouse monoclonal [447C2a] to Nurr1
- Suitable for: WB
- Reacts with: Recombinant fragment
- Isotype: IgG1
概述
-
产品名称
Anti-Nurr1抗体[447C2a]
参阅全部 Nurr1 一抗 -
描述
小鼠单克隆抗体[447C2a] to Nurr1 -
宿主
Mouse -
经测试应用
适用于: WBmore details -
种属反应性
与反应: Recombinant fragment -
免疫原
Nurr1 recombinant fragment (Human)
-
常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
-
形式
Liquid -
存放说明
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. -
存储溶液
pH: 7.40
Preservative: 0.05% Sodium azide
Constituents: 0.03% Potassium phosphate, 0.812% Sodium chloride, 0.1312% Sodium phosphate, 0.0225% Potassium chloride, 1% BSA, PBS -
Concentration information loading... -
纯度
Protein G purified -
纯化说明
ab54366 was purified using protein G column chromatography from culture supernatant of hybridoma cultured in a medium containing bovine IgG depleted (approximately 95%) fetal bovine serum and filtered through a 0.22µm membrane. -
克隆
单克隆 -
克隆编号
447C2a -
同种型
IgG1 -
研究领域
相关产品
-
Compatible Secondaries
-
Isotype control
-
Recombinant Protein
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab54366于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度；实际最佳的稀释度/浓度应由使用者检定。
| 应用 | Ab评论 | 说明 |
|---|---|---|
| WB |
Use at an assay dependent concentration. Detects a band of approximately 37 kDa (predicted molecular weight: 66 kDa).
|
| 说明 |
|---|
|
WB
Use at an assay dependent concentration. Detects a band of approximately 37 kDa (predicted molecular weight: 66 kDa). |
靶标
-
功能
Transcriptional regulator which is important for the differentiation and maintenance of meso-diencephalic dopaminergic (mdDA) neurons during development. It is crucial for expression of a set of genes such as SLC6A3, SLC18A2, TH and DRD2 which are essential for development of mdDA neurons. -
组织特异性
Expressed in a number of cell lines of T-cell, B-cell and fibroblast origin. Strong expression in brain tissue. -
序列相似性
Belongs to the nuclear hormone receptor family. NR4 subfamily.
Contains 1 nuclear receptor DNA-binding domain. -
发展阶段
Rapidly and only very transiently expressed after cell activation, during the G0-G1 transition of the cell cycle. -
细胞定位
Nucleus. - Information by UniProt
-
别名
- HZF 3 antibody
- HZF3 antibody
- Immediate-early response protein NOT antibody
see all
图片
-
Western blot - Anti-Nurr1 antibody [447C2a] (ab54366)Anti-Nurr1 antibody [447C2a] (ab54366) + immunised recombinant protein
Predicted band size: 66 kDa
Observed band size: 37 kDa why is the actual band size different from the predicted?
数据表及文件
-
Datasheet download
文献 (2)
ab54366 被引用在 2 文献中.
- Yao L et al. IGF2-NR4A2 Signaling Regulates Macrophage Subtypes to Attenuate Liver Cirrhosis. J Clin Transl Hepatol 11:787-799 (2023). PubMed: 37408817
- Xu Y et al. Decreased expression levels of Nurr1 are associated with chronic inflammation in patients with type 2 diabetes. Mol Med Rep 12:5487-93 (2015). PubMed: 26239742
