AB73293

Anti-NUP160抗体

Name: NUP160抗体 (ab73293)| Abcam中文官网
Brand: Abcam Limited
SKU: AB73293
Price: 4922 CNY
Availability: InStock

Anti-NUP160 antibody

Be the first to review this product! Submit a review

(2 Publications)

Rabbit Polyclonal NUP160 antibody. Suitable for WB and reacts with Rat samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Human NUP160.

查看别名

KIAA0197, NUP120, NUP160, Nuclear pore complex protein Nup160, 160 kDa nucleoporin, Nucleoporin Nup160

1 Images

Unknown

Western blot - Anti-NUP160 antibody (AB73293)

Lane 1:

Western blot - Anti-NUP160 antibody (ab73293) at 0.5 µg/mL

Lane 2:

Western blot - Anti-NUP160 antibody (ab73293) at 1 µg/mL

All lanes:

rat brain tissue lysate at 15 µg

Predicted band size: 162 kDa

Observed band size: 160 kDa,70 kDa

false

关键信息

宿主种属

Rabbit

克隆

Polyclonal

亚型

IgG

不含载体蛋白

反应种属

Rat

应用

applications

免疫原

Synthetic Peptide within Human NUP160. The exact immunogen used to generate this antibody is proprietary information.

Q12769

style

left-column

反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Rat": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.5-1 µg/mL", "WB-species-notes": "<p></p>" } } }

style

left-column

style

left-column

性能和储存信息

形式

Liquid

纯化工艺

Affinity purification Immunogen

存储溶液

pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS

运输条件

Blue Ice

补充信息

This supplementary information is collated from multiple sources and compiled automatically.

NUP160 also known as nucleoporin 160 is a component of the nuclear pore complex (NPC). It has a molecular mass of approximately 160 kDa. NUP160 is expressed in many types of cells throughout the body particularly in the nuclear envelope where it plays a role in nucleo-cytoplasmic transport. NUP160 forms a part of the structural scaffold of the nuclear pore complex which is essential for the transport of molecules between the nucleus and the cytoplasm.

Biological function summary

NUP160 plays an important function in the regulation of RNA and protein transport across the nuclear envelope. This protein is a part of the Y-complex an important structural component of the nuclear pore complex consisting of multiple nucleoporins. NUP160 contributes to the assembly and maintenance of the pore. By facilitating the controlled exchange of macromolecules NUP160 helps maintain cellular homeostasis and the flow of genetic information.

Pathways

NUP160 is critically involved in nucleocytoplasmic transport and gene expression regulation. It plays a significant role in the transport pathway where it interacts with importins and exportins proteins that mediate the transport of cargo molecules through the nuclear pore complex. NUP160 also links to the Ran GTPase cycle an important process for directional transport by working with related proteins like RanBP2.

NUP160 is associated with nephrotic syndrome and cancer. Abnormal expression or mutations in NUP160 and the related protein NUP93 have been observed in cases of steroid-resistant nephrotic syndrome affecting kidney function. Additionally alterations in NUP160 expression can influence oncogenesis as the protein's disruption could lead to faulty nucleocytoplasmic transport contributing to cancer progression. Understanding the connection between NUP160 and these diseases can offer insights into potential therapeutic targets.

style

left-column

style

left-column

产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

style

left-column

靶点信息

Functions as a component of the nuclear pore complex (NPC) (PubMed : 11564755, PubMed : 11684705). Involved in poly(A)+ RNA transport.

See full target information NUP160

style

left-column

文献 (2)

Recent publications for all applications. Explore the full list and refine your search

Nature communications 14:3782 PubMed37355754

2023

The HIV-1 capsid core is an opportunistic nuclear import receptor.

Applications

Unspecified application

Species

Unspecified reactive species

Guangai Xue,Hyun Jae Yu,Cindy Buffone,Szu-Wei Huang,KyeongEun Lee,Shih Lin Goh,Anna T Gres,Mehmet Hakan Guney,Stefan G Sarafianos,Jeremy Luban,Felipe Diaz-Griffero,Vineet N KewalRamani

Regenerative therapy 21:87-95 PubMed35785044

2022

NUP160 knockdown inhibits the progression of diabetic nephropathy and .

Applications

Unspecified application

Species

Unspecified reactive species

Jiayong Xie,Zhi Chen,Gang Yao,Ying Yuan,Wenjuan Yu,Qiang Zhu

View all publications

style

left-column

style

left-column

style

right-column

Abcam Product Promise

我们致力于为您的研究提供高质量的试剂，为您科研的每一步提供支持。若我们的产品未能达到预期性能，我们向您提供 Abcam Product Promise 保障。

详情请参阅我们的条款与条件。

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-NUP160抗体

Anti-NUP160 antibody

Western blot - Anti-NUP160 antibody (AB73293)