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AB250032

重组Anti-Nup107抗体[EPR12242] - BSA and Azide free

Anti-Nup107 antibody [EPR12242] - BSA and Azide free

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(1 Publication)

Rabbit Recombinant Monoclonal Nup107 antibody. Carrier free. Suitable for WB and reacts with Human samples. Cited in 1 publication.

查看别名

Nuclear pore complex protein Nup107, 107 kDa nucleoporin, Nucleoporin Nup107, NUP107

1 Images
Western blot - Anti-Nup107 antibody [EPR12242] - BSA and Azide free (AB250032)
  • WB

Supplier Data

Western blot - Anti-Nup107 antibody [EPR12242] - BSA and Azide free (AB250032)

This data was developed using ab178399, the same antibody clone in a different buffer formulation.

All lanes:

Western blot - Anti-Nup107 antibody [EPR12242] (<a href='/products/primary-antibodies/nup107-antibody-epr12242-ab178399'>ab178399</a>) at 1/10000 dilution

Lane 1:

293T cell lysate at 10 µg

Lane 2:

HeLa cell lysate at 10 µg

Lane 3:

BxPC-3 cell lysate at 10 µg

Secondary

All lanes:

Goat anti-rabbit HRP at 1/2000 dilution

Predicted band size: 106 kDa

true

不同偶联物与剂型 (1)

关键信息

宿主种属

Rabbit

克隆

Monoclonal

克隆号

EPR12242

亚型

IgG

不含载体蛋白

Yes

反应种属

Human

应用

WB

applications

免疫原

The exact immunogen used to generate this antibody is proprietary information.

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替代产品

Primary Antibodies

AB236634

Anti-Nup107 antibody [EPR22877-21]

RabMAb|Recombinant

Immunoprecipitation - Anti-Nup107 antibody [EPR22877-21] (AB236634)

  • 0
  • 0
Primary Antibodies

AB256530

Anti-Nup107 antibody [EPR22877-21] - BSA and Azide free

RabMAb|Recombinant

Immunoprecipitation - Anti-Nup107 antibody [EPR22877-21] - BSA and Azide free (AB256530)

  • 0
  • 0

搭配使用产品

Primary Antibodies

AB155990

Anti-NUP133 antibody [EPR10808(B)]

RabMAb|Recombinant

Immunocytochemistry/ Immunofluorescence - Anti-NUP133 antibody [EPR10808(B)] (AB155990)

  • 5
  • 2
Primary Antibodies

AB24609

Anti-Nuclear Pore Complex Proteins antibody [Mab414]

Immunocytochemistry/ Immunofluorescence - Anti-Nuclear Pore Complex Proteins antibody [Mab414] (AB24609)

  • 4
  • 12
Primary Antibodies

AB92360

Anti-RanGAP1 antibody [EPR3295]

RabMAb|Recombinant

Immunocytochemistry/ Immunofluorescence - Anti-RanGAP1 antibody [EPR3295] (AB92360)

  • 5
  • 3
Primary Antibodies

AB314500

Anti-Lamin C antibody [EPR28295-16] - Nuclear Envelope Marker

BOND RX™ Validated|20ul selling size|RabMAb|Recombinant|KO Validated

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Lamin C antibody [EPR28295-16] - Nuclear Envelope Marker (AB314500)

  • 0
  • 0
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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IP" : {"fullname" : "Immunoprecipitation", "shortname":"IP"}, "FlowCyt" : {"fullname" : "Flow Cytometry", "shortname":"Flow Cyt"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IP-species-checked": "notRecommended", "IP-species-dilution-info": "", "IP-species-notes": "<p></p>", "FlowCyt-species-checked": "notRecommended", "FlowCyt-species-dilution-info": "", "FlowCyt-species-notes": "<p></p>", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "", "WB-species-notes": "<p></p>", "IHCP-species-checked": "notRecommended", "IHCP-species-dilution-info": "", "IHCP-species-notes": "<p></p>", "ICCIF-species-checked": "notRecommended", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "<p></p>" }, "Rat": { "IP-species-checked": "notRecommended", "IP-species-dilution-info": "", "IP-species-notes": "", "FlowCyt-species-checked": "notRecommended", "FlowCyt-species-dilution-info": "", "FlowCyt-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "notRecommended", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "notRecommended", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" } } }
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产品详情

ab250032 is the carrier-free version of ab178399.

Species reactivity
Mouse: We have preliminary internal testing data to indicate this antibody may not react with this species.
Please contact us for more information.

Patented technology
Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.

What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:

  • - High batch-to-batch consistency and reproducibility
  • - Improved sensitivity and specificity
  • - Long-term security of supply
  • - Animal-free batch production

For more information, read more on recombinant antibodies.

Conjugation ready
Our carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.

Use our conjugation kits for antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.

Compatibility
This product is compatible with the Maxpar® Antibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar® is a trademark of Fluidigm Canada Inc.

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性能和储存信息

形式
Liquid
纯化工艺
Affinity purification
存储溶液
pH: 7.2 - 7.4 Constituents: PBS
运输条件
Blue Ice
推荐的短期储存条件
+4°C
推荐的长期储存条件
+4°C
储存信息
Do Not Freeze
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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

The Nup107 also known as nucleoporin 107 is an important protein component of the nuclear pore complex (NPC). With a molecular mass of approximately 107 kDa it is a significant element in the structure of the NPC. Nup107 is expressed in various tissues throughout the body. It plays an essential mechanical role in the assembly and maintenance of NPCs facilitating the transport of macromolecules between the nucleus and the cytoplasm.
Biological function summary

Nup107 forms part of the Nup107-160 subcomplex which contributes to the NPC's structural integrity and function. This complex acts as a scaffold providing support for the overall architecture and positioning within the nuclear envelope. The presence of Nup107 influences nuclear-cytoplasmic transport which is key in regulation of gene expression and cell cycle progression. Nup107 ensures proper assembly serving as an anchor for other nucleoporins within the NPC.

Pathways

The Nup107 subcomplex plays a critical role in key cellular processes such as the cell cycle and gene expression regulation. It participates in the mitotic entry and exit by regulating nucleocytoplasmic transport of cell cycle regulators and transcription factors. Nup107 interacts with proteins like Nup133 and Nup160 which assist in these processes. The precise functioning of Nup107 is necessary for maintaining cellular homeostasis and successful progression through cell division.

Nup107 has links to conditions such as primary ovarian insufficiency and nephrotic syndrome. Mutations or aberrant expression of Nup107 disrupt NPC assembly or function potentially leading to impaired cellular transport and altered cellular functions. In ovarian insufficiency altered Nup107 expression affects folliculogenesis by disrupting nuclear transport of specific factors. In nephrotic syndrome Nup107 dysfunction impacts the glomerular filtration barrier with associated proteins like nephrin and podocin demonstrating interrelated pathological effects.
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产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:
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靶点信息

Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance (PubMed : 12552102, PubMed : 15229283, PubMed : 30179222). Required for the assembly of peripheral proteins into the NPC (PubMed : 12552102, PubMed : 15229283). May anchor NUP62 to the NPC (PubMed : 15229283). Involved in nephrogenesis (PubMed : 30179222).
See full target information Nuclear pore complex protein Nup107
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文献 (1)

Recent publications for all applications. Explore the full list and refine your search

Molecular medicine (Cambridge, Mass.) 31:65 PubMed39972431

2025

Mechanism of histone demethylase KDM5A in osteoporotic fracture healing through epigenetic regulation of the miR-495/SKP2/Runx2 axis.

Applications

Unspecified application

Species

Unspecified reactive species

Zhuoran Li,Junyan Zhang,Tingting Xu,Zhiying Hao,Yadong Li
View all publications
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