Anti-NuMA抗体[A73-B/D12] (ab5675)
Key features and details
- Mouse monoclonal [A73-B/D12] to NuMA
- Suitable for: IHC-Fr, IHC-P, IP, WB
- Reacts with: Human
- Isotype: IgM
概述
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产品名称
Anti-NuMA抗体[A73-B/D12]
参阅全部 NuMA 一抗 -
描述
小鼠单克隆抗体[A73-B/D12] to NuMA -
宿主
Mouse -
特异性
Reacts with an intracellular 228 kD protein found in the nucleus during interphase. -
经测试应用
适用于: IHC-Fr, IHC-P, IP, WBmore details -
种属反应性
与反应: Human -
免疫原
The details of the immunogen for this antibody are not available.
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阳性对照
- Tonsil, Thymus, Spleen.
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常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Store at +4°C. Do Not Freeze. -
存储溶液
pH: 7.40
Preservative: 0.1% Sodium azide
Constituent: PBS -
Concentration information loading...
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纯度
Protein G purified -
克隆
单克隆 -
克隆编号
A73-B/D12 -
同种型
IgM -
研究领域
相关产品
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Alternative Versions
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Compatible Secondaries
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Recombinant Protein
应用
应用 | Ab评论 | 说明 |
---|---|---|
IHC-Fr |
Use at an assay dependent concentration.
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IHC-P |
Use at an assay dependent concentration.
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|
IP |
Use at an assay dependent concentration.
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|
WB |
Use at an assay dependent concentration.
|
说明 |
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IHC-Fr
Use at an assay dependent concentration. |
IHC-P
Use at an assay dependent concentration. |
IP
Use at an assay dependent concentration. |
WB
Use at an assay dependent concentration. |
靶标
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功能
May be a structural component of the nucleus. -
细胞定位
Nucleus. Chromosome. Dissociates from condensing chromosomes during early prophase, before the complete disintegration of the nuclear lamina. As mitosis progresses it reassociates with telophase chromosomes very early during nuclear reformation, before substantial accumulation of lamins on chromosomal surfaces is evident. - Information by UniProt
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数据库链接
- Entrez Gene: 4926 Human
- Omim: 164009 Human
- SwissProt: Q14980 Human
- Unigene: 325978 Human
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别名
- Centrophilin stabilizes mitotic spindle in mitotic cells antibody
- NMP 22 antibody
- Nuclear matrix protein 22 antibody
see all
实验方案
数据表及文件
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SDS download
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Datasheet download
文献 (9)
ab5675 被引用在 9 文献中.
- Beckmann D et al. Hippocampal Synaptic Plasticity, Spatial Memory, and Neurotransmitter Receptor Expression Are Profoundly Altered by Gradual Loss of Hearing Ability. Cereb Cortex 30:4581-4596 (2020). PubMed: 32202614
- Abd-Elrahman KS et al. mGluR5 Contribution to Neuropathology in Alzheimer Mice Is Disease Stage-Dependent. ACS Pharmacol Transl Sci 3:334-344 (2020). PubMed: 32296772
- Peng K et al. Mechanisms Underlying Enhancement of Spontaneous Glutamate Release by Group I mGluRs at a Central Auditory Synapse. J Neurosci 40:7027-7042 (2020). PubMed: 32801152
- Abd-Elrahman KS et al. Autophagy is increased following either pharmacological or genetic silencing of mGluR5 signaling in Alzheimer's disease mouse models. Mol Brain 11:19 (2018). PubMed: 29631635
- Burch A et al. A novel synaptic junction preparation for the identification and characterization of cleft proteins. PLoS One 12:e0174895 (2017). PubMed: 28362857
- Goniotaki D et al. Inhibition of group-I metabotropic glutamate receptors protects against prion toxicity. PLoS Pathog 13:e1006733 (2017). PubMed: 29176838
- Han K et al. SHANK3 overexpression causes manic-like behaviour with unique pharmacogenetic properties. Nature 503:72-7 (2013). PubMed: 24153177
- Shi JG et al. Tissue engineering of ureteral grafts by seeding urothelial differentiated hADSCs onto biodegradable ureteral scaffolds. J Biomed Mater Res A 100:2612-22 (2012). ICC/IF . PubMed: 22615210
- Kwong J et al. An antagonist of the chemokine receptor CXCR4 induces mitotic catastrophe in ovarian cancer cells. Mol Cancer Ther 8:1893-905 (2009). PubMed: 19567818