AB168254

Anti-NPTXR抗体

Name: NPTXR抗体 (ab168254)| Abcam中文官网
Brand: Abcam Limited
SKU: AB168254
Price: 4560 CNY
Availability: InStock
Rating: 4 (1 reviews)

Anti-NPTXR antibody

(1 Review)

(2 Publications)

Mouse Polyclonal NPTXR antibody. Suitable for WB and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human NPTXR.

查看别名

Neuronal pentraxin receptor, NPTXR

1 Images

Unknown

Western blot - Anti-NPTXR antibody (AB168254)

All lanes:

Western blot - Anti-NPTXR antibody (ab168254) at 1 µg/mL

Lane 1:

NPTXR transfected 293T cell lysate at 15 µL

Lane 2:

Non-transfected 293T cell lysate at 15 µL

Predicted band size: 53 kDa

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关键信息

宿主种属

Mouse

克隆

Polyclonal

亚型

IgG

不含载体蛋白

反应种属

Human

应用

applications

免疫原

Recombinant Full Length Protein corresponding to Human NPTXR.

O95502

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1 µg/mL", "WB-species-notes": "<p></p>" }, "Chimpanzee": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Common marmoset": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Cow": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Gorilla": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Pig": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Rhesus monkey": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" } } }

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性能和储存信息

形式

Liquid

纯化工艺

Affinity purification Protein A

存储溶液

pH: 7.4 Constituents: PBS

运输条件

Blue Ice

分装信息

Upon delivery aliquot

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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

NPTXR also known as Neuronal Pentraxin Receptor is a protein involved in the synaptic organization. It has a molecular mass of approximately 65 kDa. NPTXR expresses mainly in the central nervous system including the brain and spinal cord. As a synaptic protein it plays a role in modulating neuron-neuron interactions and signaling pathways critical for the central nervous system's proper function.

Biological function summary

Neuronal pentraxin receptor contributes to synaptic plasticity and maintenance. It forms a complex with other pentraxin proteins like NPTX1 and NPTX2 facilitating the clustering of AMPA receptors at synapses. This interaction enhances excitatory synaptic transmission which is important for processes like learning and memory. NPTXR therefore plays a significant role in maintaining synaptic strength and integrity.

Pathways

The neuronal pentraxin receptor influences the glutamatergic signaling pathway. This pathway involves neurotransmitter glutamate and its receptors which include AMPA-type glutamate receptors at postsynaptic sites. NPTXR's interaction with AMPA receptors via NPTX1 and NPTX2 promotes receptor clustering critical for NMDA receptor phosphorylation. As a result this protein contributes to synaptic plasticity influencing learning and memory pathways in neurons.

NPTXR has implications in neurodegenerative diseases and schizophrenia. Altered synaptic plasticity and receptor clustering can lead to cognitive deficits frequently observed in Alzheimer's disease. Additionally studies suggest a potential link between NPTXR and schizophrenia where dysregulated synaptic organization impacts neurotransmission. NPTXR's association with AMPA receptors through other pentraxins implicates it in these disorders highlighting its significance as a therapeutic target.

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产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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靶点信息

May be involved in mediating uptake of synaptic material during synapse remodeling or in mediating the synaptic clustering of AMPA glutamate receptors at a subset of excitatory synapses.

See full target information NPTXR

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文献 (2)

Recent publications for all applications. Explore the full list and refine your search

FASEB journal : official publication of the Federation of American Societies for Experimental Biology 35:e21194 PubMed33337553

2020

C1QL3 promotes cell-cell adhesion by mediating complex formation between ADGRB3/BAI3 and neuronal pentraxins.

Applications

Unspecified application

Species

Unspecified reactive species

Matthew J Sticco,Perla A Peña Palomino,David Lukacsovich,Brianna L Thompson,Csaba Földy,Susanne Ressl,David C Martinelli

Journal of assisted reproduction and genetics 32:1079-88 PubMed26003656

2015

Effect of Anti-Müllerian hormone (AMH) and bone morphogenetic protein 15 (BMP-15) on steroidogenesis in primary-cultured human luteinizing granulosa cells through Smad5 signalling.

Applications

Unspecified application

Species

Unspecified reactive species

Ermioni Prapa,Anna Vasilaki,Konstantinos Dafopoulos,Eleni Katsiani,Panagiotis Georgoulias,Christina I Messini,George Anifandis,Ioannis E Messinis

View all publications

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Anti-NPTXR抗体

Anti-NPTXR antibody

Western blot - Anti-NPTXR antibody (AB168254)