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AB224451

Anti-Norbin抗体

Anti-Norbin antibody

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(1 Publication)

Rabbit Polyclonal Norbin antibody. Suitable for IHC-P, WB, ICC/IF and reacts with Human, Mouse, Rat samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human NCDN aa 600-750.

查看别名

KIAA0607, NCDN, Neurochondrin

4 Images
Immunocytochemistry/ Immunofluorescence - Anti-Norbin antibody (AB224451)
  • ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-Norbin antibody (AB224451)

PFA-fixed/Triton X-100 permeabilized U-2 OS (human bone osteosarcoma epithelial cell line) cells stained for Norbin (green) using ab224451 (4 μg/ml) in ICC/IF.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Norbin antibody (AB224451)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Norbin antibody (AB224451)

Paraffin embedded human cerebral cortex tissue stained for Norbin with ab224451 (1/500 dilution) in immunohistochemical analysis.

Western blot - Anti-Norbin antibody (AB224451)
  • WB

Supplier Data

Western blot - Anti-Norbin antibody (AB224451)

All lanes:

Western blot - Anti-Norbin antibody (ab224451) at 1/100 dilution

Lane 1:

NIH/3T3 (mouse embryo fibroblast cell line) cell lysate

Lane 2:

NBT-II (rat cell line) cell lysate

Predicted band size: 79 kDa

false

Western blot - Anti-Norbin antibody (AB224451)
  • WB

Supplier Data

Western blot - Anti-Norbin antibody (AB224451)

All lanes:

Western blot - Anti-Norbin antibody (ab224451) at 1/100 dilution

All lanes:

human cerebral cortex tissue lysate

Predicted band size: 79 kDa

false

关键信息

宿主种属

Rabbit

克隆

Polyclonal

亚型

IgG

不含载体蛋白

No

反应种属

Mouse, Rat, Human

应用

WB, ICC/IF, IHC-P

applications

免疫原

Recombinant Fragment Protein within Human NCDN aa 600-750. The exact immunogen used to generate this antibody is proprietary information.

Q9UBB6

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/500 - 1/1000", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.04-0.4 µg/mL", "WB-species-notes": "<p></p>", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "0.25-2 µg/mL", "ICCIF-species-notes": "<p>Fixation/Permeabilization: PFA/Triton X-100.</p>" }, "Mouse": { "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.04-0.4 µg/mL", "WB-species-notes": "<p></p>", "ICCIF-species-checked": "guaranteed", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Rat": { "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.04-0.4 µg/mL", "WB-species-notes": "<p></p>", "ICCIF-species-checked": "guaranteed", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Cow": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" } } }
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性能和储存信息

形式
Liquid
纯化工艺
Affinity purification Immunogen
存储溶液
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
运输条件
Blue Ice
推荐的短期储存时间
1-2 weeks
推荐的短期储存条件
+4°C
推荐的长期储存条件
-20°C
分装信息
Upon delivery aliquot
储存信息
Avoid freeze / thaw cycle
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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

Norbin also known as neurochondrin is a protein with a mass of approximately 80 kDa. It is expressed widely in the central nervous system with significant levels present in neurons. Norbin plays a mechanical role by interacting directly with various signaling proteins acting as an anchor within cell signaling frameworks. The interactions help regulate multiple cellular processes important for neuronal function and communication indicating Norbin's significance in neurophysiological activities.
Biological function summary

The actions of proteins within the cell often influence cellular signaling and communication. Norbin is a part of several protein complexes assisting in the regulation of signal transduction pathways particularly those involving G-protein-coupled receptors (GPCRs). These interactions highlight Norbin's role in maintaining synaptic function and neuronal excitability. Norbin also affects synaptic plasticity contributing to learning and memory processes by modulating neurotransmission efficiency.

Pathways

Various signaling processes within cells are interlinked and Norbin integrates into the calcium signaling and MAPK pathways. In these pathways Norbin interacts closely with proteins like mGluR5 (a type of metabotropic glutamate receptor) to mediate downstream effects on neuronal activity and development. This association impacts cellular processes by controlling cellular responses to environmental stimuli thereby affecting overall nervous system functionality.

Proteins and pathways often correlate with specific conditions. Norbin's involvement with neurophysiological pathways links it to neurological disorders such as schizophrenia and Alzheimer's disease. During disease states altered Norbin expression or dysregulation may impact its interaction with proteins like mGluR5 exacerbating symptoms or progression of these conditions. Research into Norbin's role offers potential therapeutic insights into these neurological disorders.
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产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:
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靶点信息

Probably involved in signal transduction in the nervous system, via increasing cell surface localization of GRM5/mGluR5 and positively regulating its signaling (PubMed : 33711248). Required for the spatial learning process. Acts as a negative regulator of Ca(2+)-calmodulin-dependent protein kinase 2 (CaMK2) phosphorylation. May play a role in modulating melanin-concentrating hormone-mediated functions via its interaction with MCHR1 that interferes with G protein-coupled signal transduction. May be involved in bone metabolism. May also be involved in neurite outgrowth (Probable).
See full target information NCDN
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文献 (1)

Recent publications for all applications. Explore the full list and refine your search

Histology and histopathology 39:877-887 PubMed37750664

2023

Selenomethionine suppresses head and neck squamous cell carcinoma progression through TopBP1/ATR and TCAB1 signaling.

Applications

Unspecified application

Species

Unspecified reactive species

Bo Zhang,Xiaodong Wei,Jiwu Li
View all publications
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