AB107611

Anti-NLRX1抗体

Name: NLRX1抗体 (ab107611)| Abcam中文官网
Brand: Abcam Limited
SKU: AB107611
Price: 4744 CNY
Availability: InStock

Anti-NLRX1 antibody

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(5 Publications)

Rabbit Polyclonal NLRX1 antibody. Suitable for IHC-P, WB and reacts with Human, Mouse, Horse samples. Cited in 5 publications. Immunogen corresponding to Synthetic Peptide within Human NLRX1 aa 550-650.

查看别名

NOD5, NOD9, NLRX1, NLR family member X1, Caterpiller protein 11.3, Nucleotide-binding oligomerization domain protein 5, Nucleotide-binding oligomerization domain protein 9, CLR11.3

3 Images

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-NLRX1 antibody (AB107611)

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-NLRX1 antibody (AB107611)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of Human heart tissue labelling NLRX1 with ab107611 at 10μg/ml. Staining was enhanced by boiling tissue sections in 10mM sodium citrate buffer, pH6.0 for 10-20 minutes followed by cooling at room temperature for 20 minutes.

IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-NLRX1 antibody (AB107611)

ab107611, at 5μg, staining NLRX1 in formalin-fixed, paraffin-embedded Human brain tissue by immunohistochemisty.

Unknown

Western blot - Anti-NLRX1 antibody (AB107611)

All lanes:

Western blot - Anti-NLRX1 antibody (ab107611) at 5 µg/mL

Lane 1:

Mouse heart tissue lysate in absence immunizing peptide at 40 µg

Lane 2:

Mouse heart tissue lysate in presence of immunuzing peptide at 40 µg

Secondary

All lanes:

Goat anti-Rabbit Ig HRP

Predicted band size: 107 kDa

true

关键信息

宿主种属

Rabbit

克隆

Polyclonal

亚型

IgG

不含载体蛋白

反应种属

Mouse, Horse, Human

应用

IHC-P, WB

applications

免疫原

Synthetic Peptide within Human NLRX1 aa 550-650. The exact immunogen used to generate this antibody is proprietary information.

Q86UT6

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "5-10 µg/mL", "IHCP-species-notes": " Perform heat-mediated antigen retrieval before commencing with IHC staining protocol.", "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Mouse": { "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "5-7 µg/mL", "WB-species-notes": "" }, "Cow": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Dog": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Horse": { "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "5-10 µg/mL", "IHCP-species-notes": " Perform heat-mediated antigen retrieval before commencing with IHC staining protocol.", "WB-species-checked": "guaranteed", "WB-species-dilution-info": "5-7 µg/mL", "WB-species-notes": "" } } }

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性能和储存信息

形式

Liquid

纯化工艺

Affinity purification Protein A

存储溶液

pH: 7.4 Preservative: 0.05% Sodium azide Constituents: PBS, 0.05% BSA

运输条件

Blue Ice

补充信息

This supplementary information is collated from multiple sources and compiled automatically.

NLRX1 also known as NOD-like receptor X1 is a protein that plays a role in the regulation of immune responses and mitochondrial function. It has a molecular mass of approximately 110 kDa. NLRX1 is widely expressed in various tissues but shows higher levels in immune-related organs such as the spleen and lymph nodes. This protein is part of the NOD-like receptor family known for sensing intracellular signals and initiating immune responses.

Biological function summary

NLRX1 regulates immune functions by modulating inflammatory responses and innate immunity. It interacts with other cellular components to form complexes that impact the production of reactive oxygen species and influence mitochondrial dynamics. NLRX1 promotes mitochondrial homeostasis and cellular metabolism acting as a negative regulator of the inflammatory pathway. This protein also participates in antiviral responses by influencing signaling pathways upon detection of viral infections.

Pathways

NLRX1 plays critical roles within the NF-kB signaling and mitochondrial response pathways. It interacts with NF-kB-related proteins affecting the transcription of pro-inflammatory genes. Additionally NLRX1 connects with mitochondrial antiviral signaling proteins impacting the cell's ability to respond to viral agents. These interplays illustrate NLRX1's involvement in maintaining cellular balance in response to stress or infection.

Multiple studies link NLRX1 to conditions such as inflammatory bowel disease and viral infections like influenza. Its regulatory role in NF-kB and mitochondrial pathways connects NLRX1 to other proteins like MAVS and TRAF6 influencing the severity and outcome of these diseases. Altered NLRX1 function can disrupt immune regulation and promote chronic inflammation highlighting its importance in disease pathogenesis and potential as a therapeutic target.

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产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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靶点信息

Participates in antiviral signaling. Acts as a negative regulator of MAVS-mediated antiviral responses, through the inhibition of the virus-induced RLH (RIG-like helicase)-MAVS interaction (PubMed : 18200010). Instead, promotes autophagy by interacting with TUFM and subsequently recruiting the autophagy-related proteins ATG5 and ATG12 (PubMed : 22749352). Also regulates MAVS-dependent NLRP3 inflammasome activation to attenuate apoptosis (PubMed : 27393910). Has no inhibitory function on NF-kappa-B signaling pathway, but enhances NF-kappa-B and JUN N-terminal kinase dependent signaling through the production of reactive oxygen species (PubMed : 18219313). Regulates viral mediated-inflammation and energy metabolism in a sex-dependent manner (By similarity). In females, prevents uncontrolled inflammation and energy metabolism and thus, may contribute to the sex differences observed in infectious and inflammatory diseases (By similarity).

See full target information NLRX1

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文献 (5)

Recent publications for all applications. Explore the full list and refine your search

Oncology letters 27:264 PubMed38659420

2024

Bioinformatics analysis and experimental verification of NLRX1 as a prognostic factor for esophageal squamous cell carcinoma.

Applications

Unspecified application

Species

Unspecified reactive species

Lu Zhou,Lanlan Gan,Chen Sun,Alan Chu,Menglin Yang,Zongwen Liu

Frontiers in immunology 14:1028404 PubMed36817485

2023

Identification of immune related gene signature for predicting prognosis of cholangiocarcinoma patients.

Applications

Unspecified application

Species

Unspecified reactive species

Zi-Jian Zhang,Yun-Peng Huang,Zhong-Tao Liu,Yong-Xiang Wang,Hui Zhou,Ke-Xiong Hou,Ji-Wang Tang,Li Xiong,Yu Wen,Sheng-Fu Huang

Allergologia et immunopathologia 51:177-186 PubMed36617838

2023

NLRX1 increases human retinal pigment epithelial autophagy and reduces HO-induced oxidative stress and inflammation by suppressing FUNDC1 phosphorylation and NLRP3 activation.

Applications

Unspecified application

Species

Unspecified reactive species

Qian Wang,Fengying He,Liping Wu

Frontiers in immunology 11:591815 PubMed33362773

2020

NLRX1 Deletion Increases Ischemia-Reperfusion Damage and Activates Glucose Metabolism in Mouse Heart.

Applications

Unspecified application

Species

Unspecified reactive species

Hong Zhang,Yang Xiao,Rianne Nederlof,Diane Bakker,Pengbo Zhang,Stephen E Girardin,Markus W Hollmann,Nina C Weber,Sander M Houten,Michel van Weeghel,Richard G Kibbey,Coert J Zuurbier

The Journal of experimental medicine 214:2405-2420 PubMed28626071

2017

NLRX1 dampens oxidative stress and apoptosis in tissue injury via control of mitochondrial activity.

Applications

Unspecified application

Species

Unspecified reactive species

Geurt Stokman,Lotte Kors,Pieter J Bakker,Elena Rampanelli,Nike Claessen,Gwendoline J D Teske,Loes Butter,Harmen van Andel,Marius A van den Bergh Weerman,Per W B Larsen,Mark C Dessing,Coert J Zuurbier,Stephen E Girardin,Sandrine Florquin,Jaklien C Leemans

View all publications

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Anti-NLRX1抗体

Anti-NLRX1 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-NLRX1 antibody (AB107611)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-NLRX1 antibody (AB107611)

Western blot - Anti-NLRX1 antibody (AB107611)