Anti-NLRC5抗体(ab105411)
Key features and details
- Rabbit polyclonal to NLRC5
- Suitable for: WB
- Reacts with: Mouse
- Isotype: IgG
概述
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产品名称
Anti-NLRC5抗体 -
描述
兔多克隆抗体to NLRC5 -
宿主
Rabbit -
特异性
ab105411 is predicted to not cross react with other NLRP family members. -
经测试应用
适用于: WBmore details -
种属反应性
与反应: Mouse -
免疫原
An 18 amino acid peptide near the amino terminus of Human NLRC5 (NP_115582).
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阳性对照
- WB: EL4 cell lysate.
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常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Store at +4°C. -
存储溶液
pH: 7.2
Preservative: 0.02% Sodium azide
Constituent: PBS -
Concentration information loading... -
纯度
Immunogen affinity purified -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
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Compatible Secondaries
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Immunizing Peptide (Blocking)
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Isotype control
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab105411于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度；实际最佳的稀释度/浓度应由使用者检定。
| 应用 | Ab评论 | 说明 |
|---|---|---|
| WB |
Use a concentration of 1 - 2 µg/ml. Predicted molecular weight: 205 kDa.Can be blocked with NLRC5 peptide (ab196047).
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| 说明 |
|---|
|
WB
Use a concentration of 1 - 2 µg/ml. Predicted molecular weight: 205 kDa.Can be blocked with NLRC5 peptide (ab196047). |
靶标
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功能
Probable regulator of the NF-kappa-B and type I interferon signaling pathways. May also regulate the type II interferon signaling pathway. Plays a role in homeostatic control of innate immunity and in antiviral defense mechanisms. -
组织特异性
Expressed in spleen, thymus, lung, brain, tonsil, heart and prostate. -
序列相似性
Belongs to the NLRP family.
Contains 26 LRR (leucine-rich) repeats.
Contains 1 NACHT domain. -
细胞定位
Cytoplasm. - Information by UniProt
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数据库链接
- Entrez Gene: 434341 Mouse
- SwissProt: C3VPR6 Mouse
- Unigene: 334720 Mouse
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别名
- Caterpiller protein 16.1 antibody
- CLR16.1 antibody
- FLJ21709 antibody
see all
图片
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Western blot - Anti-NLRC5 antibody (ab105411)Anti-NLRC5 antibody (ab105411) at 1 µg/ml + EL4 cell lysate
Predicted band size: 205 kDa
实验方案
数据表及文件
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SDS download
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Datasheet download
文献 (18)
ab105411 被引用在 18 文献中.
- Sun C et al. NLRC5 Deficiency Reduces LPS-Induced Microglial Activation via Inhibition of NF-κB Signaling and Ameliorates Mice's Depressive-like Behavior. Int J Mol Sci 24:N/A (2023). PubMed: 37686068
- Hao J et al. NLRC5 restricts dengue virus infection by promoting the autophagic degradation of viral NS3 through E3 ligase CUL2 (cullin 2). Autophagy 19:1332-1347 (2023). PubMed: 36126167
- Zhu SD et al. NLRC5 Might Promote Endometrial Cancer Progression by Inducing PD-L1 Expression. Technol Cancer Res Treat 21:15330338221112742 (2022). PubMed: 35880269
- Deng Y et al. The Regulatory NOD-Like Receptor NLRC5 Promotes Ganglion Cell Death in Ischemic Retinopathy by Inducing Microglial Pyroptosis. Front Cell Dev Biol 9:669696 (2021). PubMed: 34095138
- Li P et al. Neuronal NLRC5 regulates MHC class I expression in Neuro-2a cells and also during hippocampal development. J Neurochem 152:182-194 (2020). PubMed: 31549732