Anti-Neurotensin Receptor 1/NTSR1抗体[B-N6] (ab27380)
Key features and details
- Mouse monoclonal [B-N6] to Neurotensin Receptor 1/NTSR1
- Suitable for: Flow Cyt
- Reacts with: Human
- Isotype: IgM
概述
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产品名称
Anti-Neurotensin Receptor 1/NTSR1抗体[B-N6]
参阅全部 Neurotensin Receptor 1/NTSR1 一抗 -
描述
小鼠单克隆抗体[B-N6] to Neurotensin Receptor 1/NTSR1 -
宿主
Mouse -
特异性
Recognises the membrane protein.
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经测试应用
适用于: Flow Cytmore details -
种属反应性
与反应: Human -
免疫原
Tissue, cells or virus corresponding to Neurotensin Receptor 1/NTSR1. NTR transfected CHO cell line
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常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle. -
存储溶液
pH: 7.30
Preservative: 0.09% Sodium azide
Constituents: 98.91% PBS, 1% BSA -
Concentration information loading...
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纯化说明
Gel filtration -
克隆
单克隆 -
克隆编号
B-N6 -
骨髓瘤
x63-Ag8.653 -
同种型
IgM -
轻链类型
kappa -
研究领域
相关产品
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Alternative Versions
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Compatible Secondaries
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab27380于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度;实际最佳的稀释度/浓度应由使用者检定。
应用 | Ab评论 | 说明 |
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Flow Cyt |
Use 10µl for 106 cells.
ab91545 - Mouse monoclonal IgM, is suitable for use as an isotype control with this antibody. |
说明 |
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Flow Cyt
Use 10µl for 106 cells. ab91545 - Mouse monoclonal IgM, is suitable for use as an isotype control with this antibody. |
靶标
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功能
G-protein coupled receptor for the tridecapeptide neurotensin (NTS) (PubMed:8381365, PubMed:21725197, PubMed:23140271). Signaling is effected via G proteins that activate a phosphatidylinositol-calcium second messenger system. Signaling leads to the activation of downstream MAP kinases and protects cells against apoptosis (PubMed:21725197). -
组织特异性
Expressed in prostate (at protein level). Detected in colon and peripheral blood mononuclear cells. Detected at very low levels in brain. -
序列相似性
Belongs to the G-protein coupled receptor 1 family. Neurotensin receptor subfamily. NTSR1 sub-subfamily. -
结构域
The ligand binding pocket consists mainly of extracellular loops ECL2 and ECL3, as well as transmembrane regions TM6 and TM7. -
翻译后修饰
N-gycosylated.
Palmitoylated; this is required for normal localization at membrane rafts and normal GNA11-mediated activation of down-stream signaling cascades. The palmitoylation level increases in response to neurotensin treatment. -
细胞定位
Cell membrane. Membrane raft. Palmitoylation is required for localization at CAV1-enriched membrane rafts. - Information by UniProt
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数据库链接
- Entrez Gene: 4923 Human
- Omim: 162651 Human
- SwissProt: P30989 Human
- Unigene: 590869 Human
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别名
- High affinity levocabastine insensitive neurotensin receptor antibody
- High-affinity levocabastine-insensitive neurotensin receptor antibody
- Neurotensin receptor 1 (high affinity) antibody
see all
数据表及文件
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SDS download
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Datasheet download
文献 (0)
ab27380 尚未被引用在任何文献中。