AB181353

重组Anti-Neuronatin抗体[EPR13554(B)]

Anti-Neuronatin antibody [EPR13554(B)]

RabMAb
Recombinant
了解详情

Be the first to review this product! Submit a review

(1 Publication)

Rabbit Recombinant Monoclonal Neuronatin antibody. Suitable for WB and reacts with Human samples. Cited in 1 publication.

查看别名

Neuronatin, NNAT

1 Images

Supplier Data

Western blot - Anti-Neuronatin antibody [EPR13554(B)] (AB181353)

All lanes:

Western blot - Anti-Neuronatin antibody [EPR13554(B)] (ab181353) at 1/10000 dilution

Lane 1:

Fetal brain lysate at 10 µg

Lane 2:

SH-SY5Y cell lysate at 10 µg

Predicted band size: 9 kDa

false

不同偶联物与剂型 (1)

Carrier free

Anti-Neuronatin antibody [EPR13554(B)] - BSA and Azide free

关键信息

宿主种属

Rabbit

克隆

Monoclonal

克隆号

EPR13554(B)

亚型

IgG

不含载体蛋白

反应种属

Human

应用

applications

免疫原

The exact immunogen used to generate this antibody is proprietary information.

style

left-column

style

left-column

反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IP" : {"fullname" : "Immunoprecipitation", "shortname":"IP"}, "FlowCyt" : {"fullname" : "Flow Cytometry", "shortname":"Flow Cyt"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IP-species-checked": "notRecommended", "IP-species-dilution-info": "", "IP-species-notes": "", "FlowCyt-species-checked": "notRecommended", "FlowCyt-species-dilution-info": "", "FlowCyt-species-notes": "", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/10000 - 1/50000", "WB-species-notes": "", "IHCP-species-checked": "notRecommended", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "notRecommended", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Mouse": { "IP-species-checked": "notRecommended", "IP-species-dilution-info": "", "IP-species-notes": "", "FlowCyt-species-checked": "notRecommended", "FlowCyt-species-dilution-info": "", "FlowCyt-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "notRecommended", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "notRecommended", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" } } }

style

left-column

产品详情

Patented technology
Our RabMAb^® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb^® patents.

What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:

- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production

For more information, read more on recombinant antibodies.

Species reactivity
Rat: We have preliminary internal testing data to indicate this antibody may not react with this species.
Please contact us for more information.

style

left-column

性能和储存信息

形式

Liquid

纯化工艺

Affinity purification Protein A

存储溶液

pH: 7.2 - 7.4 Preservative: 0.01% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA

运输条件

Conditional Ambient

分装信息

Upon delivery aliquot

储存信息

Avoid freeze / thaw cycle

style

left-column

补充信息

This supplementary information is collated from multiple sources and compiled automatically.

Neuronatin also known as Nnat is a protein involved in neural development. It exists as a polypeptide with a molecular weight of approximately 8 kDa. Neuronatin is expressed mainly in the brain’s central nervous system particularly in developing neurons. It plays a role in the differentiation and maturation of neural cells. Researchers also identify neuronatin in tissues such as the pituitary gland and the pancreas.

Biological function summary

Neuronatin influences the development and functioning of the nervous system. It does not form part of a complex but associates with lipid membranes. By interacting with calcium ions neuronatin participates in calcium signaling important for neuronal growth. Neuronatin also has a regulatory function in apoptosis the programmed cell death thereby affecting the overall cell population and neuronal health.

Pathways

Neuronatin plays a role in calcium ion homeostasis and neural signaling pathways. It affects the calcium signaling pathway which is essential for neural differentiation and plasticity. The protein calbindin which buffers intracellular calcium interacts with neuronatin in these pathways. Neuronatin also relates to the neurotrophin signaling pathway where it can influence neuron survival and growth.

Certain alterations in neuronatin expression link to neurological conditions such as Alzheimer's disease and epilepsy. In Alzheimer's neuronatin's interaction with amyloid precursor protein can influence the progression of the disease. Concerning epilepsy changes in calcium signaling involving neuronatin may contribute to the disorder's pathophysiology potentially connecting neuronatin with other proteins like calmodulin involved in calcium regulation.

style

left-column

style

left-column

产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

style

left-column

靶点信息

May participate in the maintenance of segment identity in the hindbrain and pituitary development, and maturation or maintenance of the overall structure of the nervous system. May function as a regulatory subunit of ion channels.

See full target information Neuronatin

style

left-column

文献 (1)

Recent publications for all applications. Explore the full list and refine your search

Frontiers in molecular neuroscience 12:35 PubMed30814928

2019

Down-Regulation of miRNA-708 Promotes Aberrant Calcium Signaling by Targeting Neuronatin in a Mouse Model of Angelman Syndrome.

Applications

Unspecified application

Species

Unspecified reactive species

Naman Vatsa,Vipendra Kumar,Brijesh Kumar Singh,Shashi Shekhar Kumar,Ankit Sharma,Nihar Ranjan Jana

View all publications

style

left-column

style

left-column

style

right-column

Abcam Product Promise

我们致力于为您的研究提供高质量的试剂，为您科研的每一步提供支持。若我们的产品未能达到预期性能，我们向您提供 Abcam Product Promise 保障。

详情请参阅我们的条款与条件。

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

重组Anti-Neuronatin抗体[EPR13554(B)]