JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB192880

重组Anti-Neuroligin 3抗体[EPR16158]

Anti-Neuroligin 3 antibody [EPR16158]

Be the first to review this product! Submit a review

|

(2 Publications)

Rabbit Recombinant Monoclonal Neuroligin 3 antibody. Suitable for WB and reacts with Mouse, Rat, Human samples. Cited in 2 publications.

查看别名

KIAA1480, NL3, NLGN3, Neuroligin-3, Gliotactin homolog

2 Images
Western blot - Anti-Neuroligin 3 antibody [EPR16158] (AB192880)
  • WB

Supplier Data

Western blot - Anti-Neuroligin 3 antibody [EPR16158] (AB192880)

All lanes:

Western blot - Anti-Neuroligin 3 antibody [EPR16158] (ab192880) at 1/2000 dilution

Lane 1:

Human hippocamus lysate at 20 µg

Lane 2:

Human pancreas lysate at 20 µg

Secondary

All lanes:

Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/1000 dilution

Predicted band size: 94 kDa

Observed band size: 94 kDa

false

Western blot - Anti-Neuroligin 3 antibody [EPR16158] (AB192880)
  • WB

Lab

Western blot - Anti-Neuroligin 3 antibody [EPR16158] (AB192880)

Blocking/Diluting Buffer and concentration : 5% NFDM /TBST

All lanes:

Western blot - Anti-Neuroligin 3 antibody [EPR16158] (ab192880) at 1.916 µg/mL

Lane 1:

Mouse brain tissue lysate at 20 µg

Lane 2:

Rat brain tissue lysate at 20 µg

Secondary

All lanes:

Western blot - Goat Anti-Rabbit IgG H&L (HRP) (<a href='/products/secondary-antibodies/goat-rabbit-igg-h-l-hrp-ab97051'>ab97051</a>) at 0.05 µg/mL

Predicted band size: 94 kDa

Observed band size: 110 kDa

false

不同偶联物与剂型 (1)

  • Carrier free

    Anti-Neuroligin 3 antibody [EPR16158] - BSA and Azide free

关键信息

宿主种属

Rabbit

克隆

Monoclonal

克隆号

EPR16158

亚型

IgG

不含载体蛋白

No

反应种属

Mouse, Rat, Human

应用

WB

applications

免疫原

The exact immunogen used to generate this antibody is proprietary information.

style
left-column

反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000 - 1/2000", "WB-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000 - 1/2000", "WB-species-notes": "<p></p>" }, "Rat": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000 - 1/2000", "WB-species-notes": "<p></p>" } } }
style
left-column

产品详情

Patented technology
Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.

What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:

  • - High batch-to-batch consistency and reproducibility
  • - Improved sensitivity and specificity
  • - Long-term security of supply
  • - Animal-free batch production

For more information, read more on recombinant antibodies.

style
left-column

性能和储存信息

形式
Liquid
纯化工艺
Affinity purification Protein A
存储溶液
pH: 7.2 - 7.4 Preservative: 0.01% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA
运输条件
Blue Ice
推荐的短期储存时间
1-2 weeks
推荐的短期储存条件
+4°C
推荐的长期储存条件
-20°C
分装信息
Upon delivery aliquot
储存信息
Avoid freeze / thaw cycle
style
left-column

补充信息

This supplementary information is collated from multiple sources and compiled automatically.

Neuroligin-3 also known as NLGN3 is a synaptic cell adhesion molecule weighing approximately 83 kilodaltons. It is expressed in the central nervous system particularly in the brain where it plays a role in synapse formation and function. The protein facilitates the connection between neurons by interacting with neurexin another synaptic protein to form a complex that links pre- and postsynaptic neurons. This interaction is essential for establishing functional synapses.
Biological function summary

A role in the central nervous system highlights the importance of NLGN3 in the development and maintenance of synaptic networks. It is part of the neuroligin family which forms complexes with neurexins across the synaptic cleft to ensure proper communication between neurons. These complexes are important for synaptic health and function playing a role in neurotransmitter receptor clustering and signal transduction which affects synaptic plasticity and strength.

Pathways

NLGN3 contributes to the regulation of synaptic plasticity and the postsynaptic density assembly pathway. It interacts with proteins such as N110 and other neuroligins which are critical for the maintenance of excitatory and inhibitory balance in neuronal circuits. This balance is significant for learning and memory processes. Neuroligin-3 through its interaction with neurexin also influences synaptic transmission by modulating the recruitment of signaling molecules at the synapse.

Abnormalities in NLGN3 are linked to neurological conditions such as autism spectrum disorders (ASD) and X-linked mental retardation. Mutations or dysregulation of NLGN3 affect synaptic function and are closely studied for their impact on neural communication in these conditions. The interaction of NLGN3 with neurexin and other neuroligins places it at the center of research focused on unraveling the pathophysiology of these disorders aiming to understand how disruption in synaptic adhesion molecules leads to cognitive and developmental challenges.
style
left-column
style
left-column

产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:
style
left-column

靶点信息

Cell surface protein involved in cell-cell-interactions via its interactions with neurexin family members. Plays a role in synapse function and synaptic signal transmission, and may mediate its effects by clustering other synaptic proteins. May promote the initial formation of synapses, but is not essential for this. May also play a role in glia-glia or glia-neuron interactions in the developing peripheral nervous system (By similarity).
See full target information NLGN3
style
left-column

文献 (2)

Recent publications for all applications. Explore the full list and refine your search

Molecular oncology 13:1018-1032 PubMed30636076

2019

CA10 and CA11 negatively regulate neuronal activity-dependent growth of gliomas.

Applications

Unspecified application

Species

Unspecified reactive species

Bangbao Tao,Yiqun Ling,Youyou Zhang,Shu Li,Ping Zhou,Xiaoqiang Wang,Bin Li,Zhong Jun,Wenchuan Zhang,Chunyan Xu,Juanhong Shi,Lifeng Wang,Wenhao Zhang,Shiting Li

Frontiers in pharmacology 8:486 PubMed28798687

2017

TET2 Protects against oxLDL-Induced HUVEC Dysfunction by Upregulating the CSE/HS System.

Applications

WB

Species

Mouse

Juan Peng,Zhi-Han Tang,Zhong Ren,Bei He,Yun Zeng,Lu-Shan Liu,Zuo Wang,Dang-Heng Wei,Xi-Long Zheng,Zhi-Sheng Jiang
View all publications
style
left-column
style
left-column
style
right-column

替代产品

Primary Antibodies

AB244265

Anti-Neuroligin 3 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Neuroligin 3 antibody (AB244265)

  • 0
  • 0
Primary Antibodies

AB186307

Anti-Neuroligin 3 antibody [N110/29]

Immunocytochemistry/ Immunofluorescence - Anti-Neuroligin 3 antibody [N110/29] (AB186307)

  • 0
  • 0

搭配使用产品

Secondary Antibodies

AB150077

Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488)

Immunocytochemistry/ Immunofluorescence - Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (AB150077)

  • 5
  • 20
Primary Antibodies

AB308452

Anti-Neuroligin 1 antibody [EPR27213-94] - BSA and Azide free

RabMAb|Recombinant

Dot Blot - Anti-Neuroligin 1 antibody [EPR27213-94] - BSA and Azide free (AB308452)

  • 0
  • 0
Primary Antibodies

AB222806

Anti-Neurexin I beta antibody

Immunocytochemistry/ Immunofluorescence - Anti-Neurexin I beta antibody (AB222806)

  • 0
  • 0
Primary Antibodies

AB8227

Anti-beta Actin antibody - Loading Control

BOND RX™ Validated|Lab Essentials

Western blot - Anti-beta Actin antibody - Loading Control (AB8227)

  • 5
  • 104

Abcam Product Promise

我们致力于为您的研究提供高质量的试剂，为您科研的每一步提供支持。若我们的产品未能达到预期性能，我们向您提供 Abcam Product Promise 保障。
详情请参阅我们的条款与条件。

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com