重组Anti-NETO2抗体[EPR3497] (ab109288)
![Western blot - Anti-NETO2 antibody [EPR3497] (ab109288)](https://www.abcam.cn/ps/products/109/ab109288/Images/ab109288-122028-anti-neto2-antibody-epr3497-western-blot.jpg "Western blot - Anti-NETO2 antibody [EPR3497] (ab109288)")
Key features and details
- Produced recombinantly (animal-free) for high batch-to-batch consistency and long term security of supply
- Rabbit monoclonal [EPR3497] to NETO2
- Suitable for: WB
- Reacts with: Mouse, Rat, Human
Related conjugates and formulations
概述
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产品名称
Anti-NETO2抗体[EPR3497]
参阅全部 NETO2 一抗 -
描述
兔单克隆抗体[EPR3497] to NETO2 -
宿主
Rabbit -
经测试应用
适用于: WBmore details
不适用于: Flow Cyt,ICC/IF or IHC-P -
种属反应性
与反应: Mouse, Rat, Human -
免疫原
Synthetic peptide. This information is proprietary to Abcam and/or its suppliers.
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阳性对照
- Human cerebellum, SH-SY5Y and Human brain lysates; Mouse and Rat brain lysates.
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常规说明
This product is a recombinant monoclonal antibody, which offers several advantages including:
- - High batch-to-batch consistency and reproducibility
- - Improved sensitivity and specificity
- - Long-term security of supply
- - Animal-free production
Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Store at -20°C. Stable for 12 months at -20°C. -
存储溶液
pH: 7.20
Preservative: 0.01% Sodium azide
Constituents: 0.31% Sodium citrate, 0.175% Sodium chloride, 0.0172% EDTA disodium salt, 59% PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA -
Concentration information loading... -
纯度
Protein A purified -
克隆
单克隆 -
克隆编号
EPR3497 -
同种型
IgG -
研究领域
相关产品
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Alternative Versions
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Isotype control
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Positive Controls
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab109288于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度；实际最佳的稀释度/浓度应由使用者检定。
| 应用 | Ab评论 | 说明 |
|---|---|---|
| WB |
1/1000 - 1/10000. Predicted molecular weight: 60 kDa.
|
| 说明 |
|---|
|
WB
1/1000 - 1/10000. Predicted molecular weight: 60 kDa. |
应用说明
Is unsuitable for Flow Cyt,ICC/IF or IHC-P.
靶标
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功能
Accessory subunit of neuronal kainate-sensitive glutamate receptors, GRIK2 and GRIK3. Increases kainate-receptor channel activity, slowing the decay kinetics of the receptors, without affecting their expression at the cell surface, and increasing the open probability of the receptor channels. Modulates the agonist sensitivity of kainate receptors. Slows the decay of kainate receptor-mediated excitatory postsynaptic currents (EPSCs), thus directly influencing synaptic transmission. -
序列相似性
Contains 2 CUB domains.
Contains 1 LDL-receptor class A domain. -
翻译后修饰
N-glycosylated. -
细胞定位
Membrane. - Information by UniProt
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数据库链接
- Entrez Gene: 81831 Human
- Entrez Gene: 74513 Mouse
- Entrez Gene: 307757 Rat
- Omim: 607974 Human
- SwissProt: Q8NC67 Human
- SwissProt: Q8BNJ6 Mouse
- SwissProt: C6K2K4 Rat
- Unigene: 444046 Human
see all -
别名
- Brain specific transmembrane protein antibody
- Brain specific transmembrane protein containing 2 CUB and 1 LDL receptor class A domains protein 2 antibody
- Brain-specific transmembrane protein containing 2 CUB and 1 LDL-receptor class A domains protein 2 antibody
see all
图片
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Western blot - Anti-NETO2 antibody [EPR3497] (ab109288)All lanes : Anti-NETO2 antibody [EPR3497] (ab109288) at 1/1000 dilution
Lane 1 : Human cerebellum lysates
Lane 2 : SH-SY5Y cell lysates
Lane 3 : Human brain lysates
Lysates/proteins at 10 µg per lane.
Predicted band size: 60 kDa -
![Western blot - Anti-NETO2 antibody [EPR3497] (ab109288)](https://www.abcam.cn/ps/products/109/ab109288/Images/ab109288-122027-anti-neto2-antibody-epr3497-western-blot.jpg)
Western blot - Anti-NETO2 antibody [EPR3497] (ab109288)All lanes : Anti-NETO2 antibody [EPR3497] (ab109288) at 1/1000 dilution
Lane 1 : mouse brain lysates
Lane 2 : rat brain lysates
Lysates/proteins at 10 µg per lane.
Predicted band size: 60 kDa -
![Anti-NETO2 antibody [EPR3497] (ab109288)](https://www.abcam.cn/ps/products/109/ab109288/Images/ab109288-3-benefits-of-recombinant-antibodies.png)
Anti-NETO2 antibody [EPR3497] (ab109288)
数据表及文件
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SDS download
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Datasheet download
文献 (6)
ab109288 被引用在 6 文献中.
- Chen X et al. TTN-AS1 accelerates the growth and migration of nasopharyngeal carcinoma cells via targeting miR-876-5p/NETO2. Mol Ther Oncolytics 24:535-546 (2022). PubMed: 35229031
- Zhang Z et al. Long non-coding RNA SNHG17 promotes lung adenocarcinoma progression by targeting the microRNA-193a-5p/NETO2 axis. Oncol Lett 22:818 (2021). PubMed: 34671432
- Polenghi A et al. Kainate Receptor Activation Shapes Short-Term Synaptic Plasticity by Controlling Receptor Lateral Mobility at Glutamatergic Synapses. Cell Rep 31:107735 (2020). PubMed: 32521260
- Vernon CG & Swanson GT Neto2 assembles with kainate receptors in DRG neurons during development and modulates neurite outgrowth in adult sensory neurons. J Neurosci N/A:N/A (2017). WB . PubMed: 28235897
- Lomash RM et al. Phosphorylation of the kainate receptor (KAR) auxiliary subunit Neto2 at serine 409 regulates synaptic targeting of the KAR subunit GluK1. J Biol Chem 292:15369-15377 (2017). PubMed: 28717010
- Hu L et al. Upregulation of NETO2 expression correlates with tumor progression and poor prognosis in colorectal carcinoma. BMC Cancer 15:1006 (2015). WB ; Human . PubMed: 26699544