AB197315

Anti-NELL1抗体

Name: NELL1抗体 (ab197315)| Abcam中文官网
Brand: Abcam Limited
SKU: AB197315
Price: 4606 CNY
Availability: InStock

Anti-NELL1 antibody

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(3 Publications)

Rabbit Polyclonal NELL1 antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Recombinant Fragment Protein within Human NELL1 aa 150-450.

查看别名

NRP1, NELL1, Protein kinase C-binding protein NELL1, NEL-like protein 1, Nel-related protein 1

2 Images

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-NELL1 antibody (AB197315)

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-NELL1 antibody (AB197315)

Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human colon carcinoma tissue labeling NELL1 with ab197315 at 1/100 dilution.

Supplier Data

Western blot - Anti-NELL1 antibody (AB197315)

All lanes:

Western blot - Anti-NELL1 antibody (ab197315) at 1/500 dilution

All lanes:

HEK293 cell lysate

Predicted band size: 90 kDa

false

关键信息

宿主种属

Rabbit

克隆

Polyclonal

亚型

IgG

不含载体蛋白

反应种属

Human

应用

WB, IHC-P

applications

免疫原

Recombinant Fragment Protein within Human NELL1 aa 150-450. The exact immunogen used to generate this antibody is proprietary information.

Q92832

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/200 - 1/1000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/100 - 1/500", "IHCP-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Rat": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }

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性能和储存信息

形式

Lyophilized

复溶

Reconstitute in 200 ul sterile H2O.

纯化工艺

Affinity purification Immunogen

存储溶液

pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 1% BSA

运输条件

Blue Ice

分装信息

Upon delivery aliquot

储存信息

Avoid freeze / thaw cycle

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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

NELL1 also known as Neural EGFL Like 1 is a protein primarily involved in cell signaling processes. Its molecular weight is approximately 87 kDa. NELL1 expresses in tissues such as bone cartilage blood vessels and the nervous system. It functions as a secreted glycoprotein and may play a role in mediating cellular communication.

Biological function summary

This protein influences cell growth differentiation and apoptosis. NELL1 is not known to be part of a multiprotein complex but it interacts with various factors that regulate tissue development. It has significant functions in osteogenesis and angiogenesis impacting bone formation and blood vessel formation. The presence of NELL1 is essential for normal skeletal development and repair.

Pathways

Multiple molecular interactions involve NELL1 in critical signaling pathways. NELL1 acts in the BMP signaling pathway an important player in bone and cartilage development. It also interacts with TGF-beta signaling pathways which regulate cell proliferation and differentiation. These interactions link NELL1 to proteins like BMP2 and TGF-beta receptors highlighting its role in cellular signaling dynamics.

NELL1 has associations with conditions like craniosynostosis and osteoporosis. Altered expression of NELL1 contributes to the premature fusion of skull bones in craniosynostosis. In osteoporosis NELL1 influences bone density and structure abnormalities. NELL1 also interacts with proteins such as RUNX2 which further contribute to the pathogenesis of these skeletal disorders.

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产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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靶点信息

Plays a role in the control of cell growth and differentiation. Promotes osteoblast cell differentiation and terminal mineralization.

See full target information NELL1

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文献 (3)

Recent publications for all applications. Explore the full list and refine your search

Virchows Archiv : an international journal of pathology 486:991-1000 PubMed39249508

2024

Clinicopathological characteristics of neural epidermal growth factor-like 1 protein-associated membranous glomerulonephritis.

Applications

Unspecified application

Species

Unspecified reactive species

Toshiki Hyodo,Shigeo Hara,Shunsuke Goto,Hideki Fujii,Shinichi Nishi,Akihiro Yoshimoto,Tomoo Itoh

Oncology reports 41:1817-1826 PubMed30628703

2019

Effect of NELL1 on lung cancer stem‑like cell differentiation.

Applications

Unspecified application

Species

Unspecified reactive species

Yuanfen Zhai,Rongbin Wei,Shuang Sha,Chengzhao Lin,Heyong Wang,Xinquan Jiang,Gentao Liu

Brazilian journal of medical and biological resear 51:e6997 PubMed29694513

2018

miR-27a protects human mitral valve interstitial cell from TNF-α-induced inflammatory injury via up-regulation of NELL-1.

Applications

Unspecified application

Species

Unspecified reactive species

Honglei Chen,Zhixu Zhang,Li Zhang,Junzhi Wang,Minghui Zhang,Bin Zhu

View all publications

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Anti-NELL1抗体

Anti-NELL1 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-NELL1 antibody (AB197315)

Western blot - Anti-NELL1 antibody (AB197315)