Anti-NEDD4-2抗体(ab124643)
Key features and details
- Rabbit polyclonal to NEDD4-2
- Suitable for: IHC-P
- Reacts with: Mouse, Human
- Isotype: IgG
概述
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产品名称
Anti-NEDD4-2抗体
参阅全部 NEDD4-2 一抗 -
描述
兔多克隆抗体to NEDD4-2 -
宿主
Rabbit -
经测试应用
适用于: IHC-Pmore details -
种属反应性
与反应: Mouse, Human
预测可用于: Rat, Horse, Guinea pig, Cow, Dog, Pig, Chimpanzee, Rhesus monkey, Gorilla, Orangutan, Elephant
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免疫原
Synthetic peptide corresponding to a region between residues 275 and 325 of Human NEDD4-2 (NP_001138439.1).
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阳性对照
- Human prostate carcinoma; Mouse teratoma tissue
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常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. -
存储溶液
pH: 6.8
Preservative: 0.09% Sodium azide
Constituents: 0.1% BSA, 99% Tris buffered saline -
Concentration information loading... -
纯度
Immunogen affinity purified -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
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Recombinant Protein
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab124643于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度；实际最佳的稀释度/浓度应由使用者检定。
| 应用 | Ab评论 | 说明 |
|---|---|---|
| IHC-P |
1/100 - 1/500. Epitope exposure is recommended. Epitope exposure with citrate buffer will enhance staining.
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| 说明 |
|---|
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IHC-P
1/100 - 1/500. Epitope exposure is recommended. Epitope exposure with citrate buffer will enhance staining. |
靶标
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功能
E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Inhibits TGF-beta signaling by triggering SMAD2 and TGFBR1 ubiquitination and proteasome-dependent degradation. Promotes ubiquitination and internalization of various plasma membrane channels such as ENaC, Nav1.2, Nav1.3, Nav1.5, Nav1.7, Nav1.8, Kv1.3, EAAT1 or CLC5. Promotes ubiquitination and degradation of SGK1 and TNK2. -
组织特异性
Ubiquitously expressed, with highest levels in prostate, pancreas and kidney. -
通路
Protein modification; protein ubiquitination. -
序列相似性
Contains 1 C2 domain.
Contains 1 HECT (E6AP-type E3 ubiquitin-protein ligase) domain.
Contains 4 WW domains. -
翻译后修饰
Phosphorylated by SGK1 or PKA; which impairs interaction with SCNN. Interaction with YWHAH inhibits dephosphorylation.
Auto-ubiquitinated. -
细胞定位
Cytoplasm. May be recruited to exosomes by NDFIP1. - Information by UniProt
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数据库链接
- Entrez Gene: 23327 Human
- Entrez Gene: 83814 Mouse
- Entrez Gene: 100172429 Orangutan
- Entrez Gene: 291553 Rat
- Omim: 606384 Human
- SwissProt: Q96PU5 Human
- SwissProt: Q8CFI0 Mouse
- SwissProt: Q5RBF2 Orangutan
see all -
别名
- E3 ubiquitin protein ligase NEDD4 like protein antibody
- E3 ubiquitin-protein ligase NEDD4-like antibody
- KIAA0439 antibody
see all
图片
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-NEDD4-2 antibody (ab124643)ab124643, at 1/250 dilution, staining NEDD4-2 in formalin-fixed, paraffin-embedded Human prostate carcinoma tissue by Immunohistochemistry with DAB staining.
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-NEDD4-2 antibody (ab124643)ab124643, at 1/250 dilution, staining NEDD4-2 in formalin-fixed, paraffin-embedded Mouse teratoma tissue by Immunohistochemistry with DAB staining.
数据表及文件
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Datasheet download
文献 (0)
ab124643 尚未被引用在任何文献中。
