Anti-NDUFA4抗体(ab129752)
Key features and details
- Rabbit polyclonal to NDUFA4
- Suitable for: ELISA, ICC/IF, WB
- Reacts with: Mouse, Human
- Isotype: IgG
概述
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产品名称
Anti-NDUFA4抗体 -
描述
兔多克隆抗体to NDUFA4 -
宿主
Rabbit -
经测试应用
适用于: ELISA, ICC/IF, WBmore details -
种属反应性
与反应: Mouse, Human
预测可用于: Rat
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免疫原
Synthetic peptide derived from internal sequence of Human NDUFA4.
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常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Store at -20°C. Stable for 12 months at -20°C. -
存储溶液
pH: 7
Preservative: 0.02% Sodium azide
Constituents: 49% PBS, 50% Glycerol (glycerin, glycerine), 0.88% Sodium chloride -
Concentration information loading... -
纯度
Immunogen affinity purified -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab129752于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度；实际最佳的稀释度/浓度应由使用者检定。
| 应用 | Ab评论 | 说明 |
|---|---|---|
| ELISA |
Use at an assay dependent concentration.
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| ICC/IF |
Use at an assay dependent concentration.
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| WB |
1/500 - 1/1000. Predicted molecular weight: 9 kDa.
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| 说明 |
|---|
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ELISA
Use at an assay dependent concentration. |
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ICC/IF
Use at an assay dependent concentration. |
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WB
1/500 - 1/1000. Predicted molecular weight: 9 kDa. |
靶标
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功能
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed to be not involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. -
序列相似性
Belongs to the complex I NDUFA4 subunit family. -
细胞定位
Mitochondrion inner membrane. - Information by UniProt
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数据库链接
- Entrez Gene: 4697 Human
- Entrez Gene: 17992 Mouse
- Entrez Gene: 681024 Rat
- Omim: 603833 Human
- SwissProt: O00483 Human
- SwissProt: Q62425 Mouse
- Unigene: 50098 Human
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别名
- CI 9k antibody
- CI-MLRQ antibody
- Complex I 9kDa subunit antibody
see all
图片
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Western blot - Anti-NDUFA4 antibody (ab129752)All lanes : Anti-NDUFA4 antibody (ab129752) at 1/100 dilution
Lane 1 : HepG2 cell extract
Lane 2 : HepG2 cell extract with immunizing peptide
Lane 3 : RAW264.7 cell extract
Predicted band size: 9 kDa
数据表及文件
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SDS download
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Datasheet download
文献 (9)
ab129752 被引用在 9 文献中.
- Fu F et al. Ndufa4 Regulates the Proliferation and Apoptosis of Neurons via miR-145a-5p/Homer1/Ccnd2. Mol Neurobiol 60:2986-3003 (2023). PubMed: 36763283
- Han Y et al. A human iPSC-array-based GWAS identifies a virus susceptibility locus in the NDUFA4 gene and functional variants. Cell Stem Cell 29:1475-1490.e6 (2022). PubMed: 36206731
- Chen Q et al. Tunicamycin-Induced Endoplasmic Reticulum Stress Damages Complex I in Cardiac Mitochondria. Life (Basel) 12:N/A (2022). PubMed: 36013387
- Wang Z et al. High throughput proteomic and metabolic profiling identified target correction of metabolic abnormalities as a novel therapeutic approach in head and neck paraganglioma. Transl Oncol 14:101146 (2021). PubMed: 34118692
- Yuan T et al. Differentially expressed proteins identified by TMT proteomics analysis in children with verrucous epidermal naevi. J Eur Acad Dermatol Venereol 35:1393-1406 (2021). PubMed: 33428294
- Mohsin AA et al. Endoplasmic reticulum stress-induced complex I defect: Central role of calcium overload. Arch Biochem Biophys 683:108299 (2020). PubMed: 32061585
- Cui S et al. LncRNA MAFG-AS1 promotes the progression of colorectal cancer by sponging miR-147b and activation of NDUFA4. Biochem Biophys Res Commun 506:251-258 (2018). PubMed: 30348529
- Hoang-Minh LB et al. Infiltrative and drug-resistant slow-cycling cells support metabolic heterogeneity in glioblastoma. EMBO J 37:N/A (2018). PubMed: 30322894
- Lee D et al. Folate cycle enzyme MTHFD1L confers metabolic advantages in hepatocellular carcinoma. J Clin Invest 127:1856-1872 (2017). PubMed: 28394261