AB67912

Anti-NDFIP2抗体

Name: NDFIP2抗体 (ab67912)| Abcam中文官网
Brand: Abcam Limited
SKU: AB67912
Price: 4744 CNY
Availability: InStock

Anti-NDFIP2 antibody

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(1 Publication)

Mouse Polyclonal NDFIP2 antibody. Suitable for WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human NDFIP2.

查看别名

KIAA1165, N4WBP5A, NDFIP2, NEDD4 family-interacting protein 2, NEDD4 WW domain-binding protein 5A, Putative MAPK-activating protein PM04/PM05/PM06/PM07, Putative NF-kappa-B-activating protein 413

1 Images

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Western blot - Anti-NDFIP2 antibody (AB67912)

All lanes:

Western blot - Anti-NDFIP2 antibody (ab67912) at 1/500 dilution

Lane 1:

NDFIP2 transfected 293T cell lysate at 25 µg

Lane 2:

non transfected 293T cell lysate at 25 µg

Secondary

All lanes:

Goat anti-mouse IgG (H&L)-HRP conjugate at 1/2500 dilution

Predicted band size: 36 kDa

Observed band size: 36 kDa

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关键信息

宿主种属

Mouse

克隆

Polyclonal

亚型

IgG

不含载体蛋白

反应种属

Human

应用

applications

免疫原

Recombinant Full Length Protein corresponding to Human NDFIP2.

Q9NV92

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/1000", "WB-species-notes": "<p></p>" } } }

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性能和储存信息

形式

Liquid

纯化工艺

Affinity purification Protein A

存储溶液

pH: 7.4 Constituents: PBS

运输条件

Blue Ice

分装信息

Upon delivery aliquot

储存信息

Avoid freeze / thaw cycle

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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

NDFIP2 also known as NEDD4 family-interacting protein 2 is an E3 ubiquitin ligase adaptor protein that plays a role in protein ubiquitination and degradation. It has a mass of approximately 24 kDa. NDFIP2 is expressed in various tissues including high levels in the brain and immune cells. It localizes to the cytoplasm and interacts with several pathways involving protein trafficking and cellular stress responses.

Biological function summary

NDFIP2 interacts with NEDD4 family E3 ubiquitin-protein ligases and plays a role in inhibiting cell surface receptor signaling by mediating the ubiquitination and subsequent degradation of the receptor complex. It participates in the regulation of adaptive immune responses and its activity adjusts according to cellular stress signals adapting the protein machinery to ensure cellular function. NDFIP2 does not form part of any complex but directly interacts with enzymes that tag proteins for degradation.

Pathways

NDFIP2 influences ubiquitin-mediated protein degradation and the JAK-STAT signaling pathway. In the ubiquitin pathway NDFIP2 works closely with NEDD4 facilitating tagging of proteins for proteasome-mediated destruction. In the JAK-STAT pathway its role in receptor regulation indirectly influences signal transduction and the expression of genes vital for immune function and growth regulation.

NDFIP2 is linked with conditions like neurodegenerative disorders and autoimmune diseases. Its expression and function alterations can influence disease outcomes by disrupting protein degradation and receptor signaling. For instance NDFIP2 interacts with proteins like NEDD4 and JAK which are involved in pathways implicated in the progression of specific neurodegenerative disorders as well as in autoimmune conditions where dysfunctional signaling leads to improper immune response.

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产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:

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Visit the Troubleshooting

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靶点信息

Activates HECT domain-containing E3 ubiquitin-protein ligases, including ITCH, NEDD4, NEDD4L, SMURF2, WWP1 and WWP2, and consequently modulates the stability of their targets. As a result, may control many cellular processes. Recruits ITCH, NEDD4 and SMURF2 to endosomal membranes. Negatively regulates KCNH2 potassium channel activity by decreasing its cell-surface expression and interfering with channel maturation through recruitment of NEDD4L to the Golgi apparatus and multivesicular body where it mediates KCNH2 degradation (PubMed : 26363003). May modulate EGFR signaling. Together with NDFIP1, limits the cytokine signaling and expansion of effector Th2 T-cells by promoting degradation of JAK1, probably by ITCH- and NEDD4L-mediated ubiquitination (By similarity).

See full target information NDFIP2

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文献 (1)

Recent publications for all applications. Explore the full list and refine your search

Scientific reports 7:46336 PubMed28402317

2017

Simultaneous and quantitative monitoring of co-cultured Pseudomonas aeruginosa and Staphylococcus aureus with antibiotics on a diffusometric platform.

Applications

Unspecified application

Species

Unspecified reactive species

Chih-Yao Chung,Jhih-Cheng Wang,Han-Sheng Chuang

View all publications

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Anti-NDFIP2抗体

Anti-NDFIP2 antibody

Western blot - Anti-NDFIP2 antibody (AB67912)