Anti-NCKAP1抗体(ab126061)
Key features and details
- Rabbit polyclonal to NCKAP1
- Suitable for: WB
- Reacts with: Human
- Isotype: IgG
概述
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产品名称
Anti-NCKAP1抗体
参阅全部 NCKAP1 一抗 -
描述
兔多克隆抗体to NCKAP1 -
宿主
Rabbit -
经测试应用
适用于: WBmore details -
种属反应性
与反应: Human
预测可用于: Mouse, Rat, Xenopus laevis, Zebrafish
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免疫原
Recombinant fragment, corresponding to a region within N terminal amino acids 2-298 of Human NCKAP1 (Q9Y2A7).
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阳性对照
- NT2D1, IMR32, U-87 MG, MCF7 whole cell lysates.
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常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle. -
存储溶液
pH: 7.00
Preservative: 0.025% Proclin 300
Constituents: 79% PBS, 20% Glycerol (glycerin, glycerine) -
Concentration information loading... -
纯度
Immunogen affinity purified -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
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Positive Controls
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab126061于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度；实际最佳的稀释度/浓度应由使用者检定。
| 应用 | Ab评论 | 说明 |
|---|---|---|
| WB |
1/500 - 1/3000. Predicted molecular weight: 128 kDa.
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| 说明 |
|---|
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WB
1/500 - 1/3000. Predicted molecular weight: 128 kDa. |
靶标
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功能
Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex. Actin remodeling activity is regulated by RAC1. -
组织特异性
Expressed in all tissues examined except peripheral blood leukocytes, with highest expression in brain, heart, and skeletal muscle. -
序列相似性
Belongs to the HEM-1/HEM-2 family. -
细胞定位
Cell membrane. Cell projection > lamellipodium membrane. At the interface between the lamellipodial actin meshwork and the membrane. - Information by UniProt
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数据库链接
- Entrez Gene: 10787 Human
- Entrez Gene: 50884 Mouse
- Entrez Gene: 58823 Rat
- Entrez Gene: 494653 Xenopus laevis
- Omim: 604891 Human
- SwissProt: Q9Y2A7 Human
- SwissProt: P28660 Mouse
- SwissProt: P55161 Rat
see all -
别名
- FLJ11291 antibody
- KIAA0587 antibody
- Membrane associated protein HEM2 antibody
see all
图片
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Western blot - Anti-NCKAP1 antibody (ab126061)Anti-NCKAP1 antibody (ab126061) at 1/1000 dilution + U-87 MG whole cell lysate at 30 µg
Predicted band size: 128 kDa
5% SDS PAGE
数据表及文件
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SDS download
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Datasheet download
文献 (3)
ab126061 被引用在 3 文献中.
- Zhu A et al. Pan-cancer Analysis of the Disulfidptosis-related Gene NCKAP1 and Its Prognostic Value for Lung Adenocarcinoma. J Cancer 14:3351-3367 (2023). PubMed: 37928421
- Ma Q et al. miR-140-5p inhibits the proliferation, migration and invasion of vascular smooth muscle cells by suppressing the expression of NCKAP1. Folia Histochem Cytobiol 59:22-29 (2021). PubMed: 33560516
- Whitelaw JA et al. The WAVE Regulatory Complex Is Required to Balance Protrusion and Adhesion in Migration. Cells 9:N/A (2020). PubMed: 32646006