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AB219862

Anti-NBR1抗体

Anti-NBR1 antibody

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(3 Publications)

Rabbit Polyclonal NBR1 antibody. Suitable for ICC/IF and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Recombinant Fragment Protein within Human NBR1 aa 50-200.

查看别名

1A13B, KIAA0049, M17S2, MIG19, NBR1, Next to BRCA1 gene 1 protein, Cell migration-inducing gene 19 protein, Membrane component chromosome 17 surface marker 2, Neighbor of BRCA1 gene 1 protein, Protein 1A1-3B

1 Images
Immunocytochemistry/ Immunofluorescence - Anti-NBR1 antibody (AB219862)
  • ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-NBR1 antibody (AB219862)

Immunofluorescent analysis of A549 cells (PFA-fixed/Triton X-100 permeabilized) labeling NBR1 with ab219862 at 4 μg/ml (green).

关键信息

宿主种属

Rabbit

克隆

Polyclonal

亚型

IgG

不含载体蛋白

No

反应种属

Human

应用

ICC/IF

applications

免疫原

Recombinant Fragment Protein within Human NBR1 aa 50-200. The exact immunogen used to generate this antibody is proprietary information.

Q14596

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替代产品

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AB126175

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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-NBR1 antibody (AB126175)

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AB226360

Anti-NBR1 antibody - C-terminal

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Primary Antibodies

AB192890

Anti-LC3B antibody [EPR18709] - Autophagosome Marker

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Western blot - Anti-LC3B antibody [EPR18709] - Autophagosome Marker (AB192890)

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Primary Antibodies

AB207305

Anti-SQSTM1 / p62 antibody [EPR18351] - Autophagosome Marker

20ul selling size|KO Validated|RabMAb|Recombinant|Lab Essentials|Trial Size

Immunocytochemistry/ Immunofluorescence - Anti-SQSTM1 / p62 antibody [EPR18351] - Autophagosome Marker (AB207305)

  • 5
  • 3
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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "0.25-2 µg/mL", "ICCIF-species-notes": "<p></p>" }, "Orangutan": { "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" } } }
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性能和储存信息

形式
Liquid
纯化工艺
Affinity purification Immunogen
存储溶液
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
运输条件
Blue Ice
推荐的短期储存时间
1-2 weeks
推荐的短期储存条件
+4°C
推荐的长期储存条件
-20°C
分装信息
Upon delivery aliquot
储存信息
Avoid freeze / thaw cycle
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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

NBR1 also known as Neighbor of BRCA1 Gene 1 functions as a receptor for selective autophagy. It recognizes ubiquitinated proteins and delivers them to autophagosomes for degradation. The protein has a molecular weight of approximately 110 kDa. Scientists have observed its expression in a variety of tissues with particularly high levels in the testis and low levels in the lung and kidney.
Biological function summary

NBR1 plays a significant role in the removal of misfolded or damaged proteins through autophagy. It acts within the p62/SQSTM1 complex which links to the autophagic machinery. The complex recruits ubiquitinated substrates facilitating their degradation in lysosomes. Through this mechanism NBR1 helps maintain cellular homeostasis and genome integrity by removing potentially harmful elements.

Pathways

NBR1 integrates into the critical cellular recycling process known as autophagy. It works closely with proteins such as p62/SQSTM1 in the ubiquitin-proteasome pathway to ensure efficient protein turnover. The protein participates in signals that control cell growth and survival influencing the mTOR pathway which is important in regulating cellular metabolism growth and life span.

Research indicates that NBR1 might have implications in neurodegenerative diseases like Alzheimer's and Parkinson's. Its involvement in autophagy suggests that malfunction or aberrant expression of NBR1 could lead to the accumulation of protein aggregates associated with these conditions. Additionally interactions with proteins such as LC3 and p62/SQSTM1 central in lysosomal degradation highlight its potential role in disease mechanisms where autophagy is disrupted.
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产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:
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靶点信息

Ubiquitin-binding autophagy adapter that participates in different processes including host defense or intracellular homeostasis (PubMed : 24692539, PubMed : 33577621). Possesses a double function during the selective autophagy by acting as a shuttle bringing ubiquitinated proteins to autophagosomes and also by participating in the formation of protein aggregates (PubMed : 24879152, PubMed : 34471133, PubMed : 38169523). Plays a role in the regulation of the innate immune response by modulating type I interferon production and targeting ubiquitinated IRF3 for autophagic degradation (PubMed : 35914352). In response to oxidative stress, promotes an increase in SQSTM1 levels, phosphorylation, and body formation by preventing its autophagic degradation (By similarity). In turn, activates the KEAP1-NRF2/NFE2L2 antioxidant pathway (By similarity). Also plays non-autophagy role by mediating the shuttle of IL-12 to late endosome for subsequent secretion (By similarity).
See full target information NBR1
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文献 (3)

Recent publications for all applications. Explore the full list and refine your search

Molecular brain 14:65 PubMed33823883

2021

Palmitate reduces starvation-induced ER stress by inhibiting ER-phagy in hypothalamic cells.

Applications

Unspecified application

Species

Unspecified reactive species

Yun Lim,Seolsong Kim,Eun-Kyoung Kim

Molecular cell 81:1337-1354.e8 PubMed33545068

2021

Systematically defining selective autophagy receptor-specific cargo using autophagosome content profiling.

Applications

Unspecified application

Species

Unspecified reactive species

Susanne Zellner,Martina Schifferer,Christian Behrends

Proceedings of the National Academy of Sciences of 116:8010-8017 PubMed30936319

2019

Pejvakin-mediated pexophagy protects auditory hair cells against noise-induced damage.

Applications

Unspecified application

Species

Unspecified reactive species

Jean Defourny,Alain Aghaie,Isabelle Perfettini,Paul Avan,Sedigheh Delmaghani,Christine Petit
View all publications
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