AB272931

Anti-Nav1.7抗体

Name: Nav1.7抗体 (ab272931)| Abcam中文官网
Brand: Abcam Limited
SKU: AB272931
Price: 5009 CNY
Availability: InStock

Anti-Nav1.7 antibody

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Rabbit Polyclonal SCN9A antibody. Suitable for WB, ICC/IF and reacts with Mouse, Rat samples. Immunogen corresponding to Synthetic Peptide within Mouse Scn9a.

查看别名

Kiaa4197, Scn9a, Sodium channel protein type 9 subunit alpha, Peripheral sodium channel 1, Sodium channel protein type IX subunit alpha, Voltage-gated sodium channel subunit alpha Nav1.7, PN1

2 Images

Immunocytochemistry/ Immunofluorescence - Anti-Nav1.7 antibody (AB272931)

ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-Nav1.7 antibody (AB272931)

4% PFA-fixed rat primary cortical neuron cells stained for Nav1.7 using ab272931 at 1/500 dilution in ICC/IF (green). Red : Tau. Blue : DAPI.

Supplier Data

Western blot - Anti-Nav1.7 antibody (AB272931)

5% SDS-PAGE

All lanes:

Western blot - Anti-Nav1.7 antibody (ab272931) at 1/3000 dilution

Lane 1:

Mouse brain tissue extracts at 30 µg

Lane 2:

Rat brain tissue extracts at 30 µg

Secondary

All lanes:

HRP-conjugated anti-rabbit IgG

Predicted band size: 226 kDa

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关键信息

宿主种属

Rabbit

克隆

Polyclonal

亚型

IgG

不含载体蛋白

反应种属

Mouse, Rat

应用

ICC/IF, WB

applications

免疫原

Synthetic Peptide within Mouse Scn9a. The exact immunogen used to generate this antibody is proprietary information.

Q62205

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/3000", "WB-species-notes": "", "ICCIF-species-checked": "guaranteed", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Rat": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/3000", "WB-species-notes": "", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "1/100 - 1/1000", "ICCIF-species-notes": "" } } }

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性能和储存信息

形式

Liquid

纯化工艺

Affinity purification Immunogen

存储溶液

pH: 7 Preservative: 0.025% Proclin 300 Constituents: PBS, 20% Glycerol (glycerin, glycerine)

运输条件

Blue Ice

分装信息

Upon delivery aliquot

储存信息

Avoid freeze / thaw cycle

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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

Nav1.7 also known as SCN9A is a voltage-gated sodium channel. This protein has a mass of approximately 260 kDa. It plays a role in the generation and conduction of action potentials in neurons. Nav1.7 is found mainly in peripheral neurons including dorsal root ganglia and sympathetic ganglia. These neurons are part of the sensory pathways responsible for transmitting pain signals.

Biological function summary

Nav1.7 acts as an essential component in neuronal excitability. It is not part of a larger protein complex but operates as an individual unit within the cell membrane. By allowing sodium ions to enter the neuron Nav1.7 contributes to the depolarization phase of action potentials. This function is critical in the propagation of electrical signals in the nervous system specifically in nociceptive neurons that are involved in pain sensation.

Pathways

Nav1.7 is integral to the nociceptive pain pathway. It works with other sodium channels such as Nav1.8 which also play roles in pain sensation. Nav1.7's activity helps to initiate and maintain action potentials facilitating the transmission of pain signals to the central nervous system. Additionally Nav1.7 is linked to neuropathic pain pathways where its function underpins the continuous firing of neurons even in the absence of external stimuli.

Nav1.7 mutations have a significant association with primary erythromelalgia and congenital indifference to pain. Mutations that cause gain-of-function in Nav1.7 can lead to primary erythromelalgia resulting in extreme pain and redness in the body’s extremities. Conversely loss-of-function mutations can cause congenital indifference to pain where individuals experience little to no pain sensation. Nav1.7 works alongside Nav1.8 in these conditions as both are involved in the modulation of pain signals.

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产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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靶点信息

Pore-forming subunit of Nav1.7, a voltage-gated sodium (Nav) channel that directly mediates the depolarizing phase of action potentials in excitable membranes. Navs, also called VGSCs (voltage-gated sodium channels) or VDSCs (voltage-dependent sodium channels), operate by switching between closed and open conformations depending on the voltage difference across the membrane. In the open conformation they allow Na(+) ions to selectively pass through the pore, along their electrochemical gradient. The influx of Na(+) ions provokes membrane depolarization, initiating the propagation of electrical signals throughout cells and tissues (By similarity). Nav1.7 plays a crucial role in controlling the excitability and action potential propagation from nociceptor neurons, thereby contributing to the sensory perception of pain (PubMed : 15314237).

See full target information Scn9a

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Anti-Nav1.7抗体

Anti-Nav1.7 antibody

Immunocytochemistry/ Immunofluorescence - Anti-Nav1.7 antibody (AB272931)

Western blot - Anti-Nav1.7 antibody (AB272931)