Anti-Natriuretic多肽A抗体(ab76743)
Key features and details
- Rabbit polyclonal to Natriuretic peptides A
- Suitable for: IHC-Fr, IHC-P, WB
- Reacts with: Human
- Isotype: IgG
选择批间可重复性更高的重组抗体
- 研究可靠 —— 各批次间结果一致且可重复
- 长期批量供应 —— 采用重组技术，可实现快速生产
- 首次实验即可成功 —— 经过大量验证确认了特异性
- 符合伦理标准 —— 产品不含动物成分
概述
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产品名称
Anti-Natriuretic多肽A抗体
参阅全部 Natriuretic peptides A 一抗 -
描述
兔多克隆抗体to Natriuretic多肽A -
宿主
Rabbit -
经测试应用
适用于: IHC-Fr, IHC-P, WBmore details -
种属反应性
与反应: Human
预测可用于: Mouse, Rat
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免疫原
Synthetic peptide corresponding to Human Natriuretic peptides A (C terminal).
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常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles. -
存储溶液
Constituent: Whole serum -
Concentration information loading... -
纯度
Whole antiserum -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
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Recombinant Protein
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab76743于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度；实际最佳的稀释度/浓度应由使用者检定。
| 应用 | Ab评论 | 说明 |
|---|---|---|
| IHC-Fr |
Use at an assay dependent concentration.
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| IHC-P |
Use at an assay dependent concentration.
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| WB |
Use at an assay dependent concentration.
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| 说明 |
|---|
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IHC-Fr
Use at an assay dependent concentration. |
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IHC-P
Use at an assay dependent concentration. |
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WB
Use at an assay dependent concentration. |
靶标
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功能
Hormone playing a key role in cardiovascular homeostasis through regulation of natriuresis, diuresis, and vasodilation. Also plays a role in female pregnancy by promoting trophoblast invasion and spiral artery remodeling in uterus. Specifically binds and stimulates the cGMP production of the NPR1 receptor. Binds the clearance receptor NPR3. -
疾病相关
Atrial standstill 2
Atrial fibrillation, familial, 6 -
序列相似性
Belongs to the natriuretic peptide family. -
翻译后修饰
Cleaved by CORIN upon secretion to produce the functional hormone.
Atrial natriuretic factor: Cleaved by MME. The cleavage initiates degradation of the factor and thereby regulate its activity. -
细胞定位
Secreted. - Information by UniProt
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数据库链接
- Entrez Gene: 4878 Human
- Entrez Gene: 230899 Mouse
- Entrez Gene: 24602 Rat
- Omim: 108780 Human
- SwissProt: P01160 Human
- SwissProt: P05125 Mouse
- SwissProt: P01161 Rat
- Unigene: 75640 Human
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别名
- ANF antibody
- ANF_HUMAN antibody
- ANP antibody
see all
数据表及文件
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Datasheet download
文献 (5)
ab76743 被引用在 5 文献中.
- Shang L et al. Plantamajoside attenuates isoproterenol-induced cardiac hypertrophy associated with the HDAC2 and AKT/ GSK-3ß signaling pathway. Chem Biol Interact 307:21-28 (2019). PubMed: 31009642
- Kang LL et al. Pterostilbene Attenuates Fructose-Induced Myocardial Fibrosis by Inhibiting ROS-Driven Pitx2c/miR-15b Pathway. Oxid Med Cell Longev 2019:1243215 (2019). PubMed: 31871537
- Cui C et al. Atrial remodeling and metabolic dysfunction in idiopathic isolated fibrotic atrial cardiomyopathy. Int J Cardiol 265:155-161 (2018). ICC/IF . PubMed: 29706431
- Rosales W et al. Role of Histone Demethylases in Cardiomyocytes Induced to Hypertrophy. Biomed Res Int 2016:2634976 (2016). WB . PubMed: 27722168
- Chow MZ et al. Epigenetic regulation of the electrophysiological phenotype of human embryonic stem cell-derived ventricular cardiomyocytes: insights for driven maturation and hypertrophic growth. Stem Cells Dev 22:2678-90 (2013). PubMed: 23656529
