Anti-Natriuretic多肽A抗体(ab180649)
Key features and details
- Rabbit polyclonal to Natriuretic peptides A
- Suitable for: WB
- Reacts with: Mouse
- Isotype: IgG
概述
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产品名称
Anti-Natriuretic多肽A抗体
参阅全部 Natriuretic peptides A 一抗 -
描述
兔多克隆抗体to Natriuretic多肽A -
宿主
Rabbit -
经测试应用
适用于: WBmore details -
种属反应性
与反应: Mouse -
免疫原
Recombinant fragment corresponding to Human Natriuretic peptides A aa 26-151.
Sequence:NPMYNAVSNADLMDFKNLLDHLEEKMPLEDEVVPPQVLSEPNEEAGAALS PLPEVPPWTGEVSPAQRDGGALGRGPWDSSDRSALLKSKLRALLTAPRSL RRSSCFGGRMDRIGAQSGLGCNSFRY
Database link: P01160 -
阳性对照
- WB: Mouse brain, heart and lung tissue lysates.
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常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle. -
存储溶液
pH: 7.30
Preservative: 0.02% Sodium azide
Constituents: 49% PBS, 50% Glycerol -
Concentration information loading... -
纯度
Immunogen affinity purified -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
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Recombinant Protein
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab180649于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度；实际最佳的稀释度/浓度应由使用者检定。
| 应用 | Ab评论 | 说明 |
|---|---|---|
| WB |
1/500 - 1/2000. Predicted molecular weight: 16 kDa.
|
| 说明 |
|---|
|
WB
1/500 - 1/2000. Predicted molecular weight: 16 kDa. |
靶标
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功能
Hormone playing a key role in cardiovascular homeostasis through regulation of natriuresis, diuresis, and vasodilation. Also plays a role in female pregnancy by promoting trophoblast invasion and spiral artery remodeling in uterus. Specifically binds and stimulates the cGMP production of the NPR1 receptor. Binds the clearance receptor NPR3. -
疾病相关
Atrial standstill 2
Atrial fibrillation, familial, 6 -
序列相似性
Belongs to the natriuretic peptide family. -
翻译后修饰
Cleaved by CORIN upon secretion to produce the functional hormone.
Atrial natriuretic factor: Cleaved by MME. The cleavage initiates degradation of the factor and thereby regulate its activity. -
细胞定位
Secreted. - Information by UniProt
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数据库链接
- Entrez Gene: 230899 Mouse
- SwissProt: P05125 Mouse
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别名
- ANF antibody
- ANF_HUMAN antibody
- ANP antibody
see all
图片
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Western blot - Anti-Natriuretic peptides A antibody (ab180649)All lanes : Anti-Natriuretic peptides A antibody (ab180649) at 1/1000 dilution
Lane 1 : Mouse brain tissue lysate
Lane 2 : Mouse heart tissue lysate
Lane 3 : Mouse lung tissue lysate
Lysates/proteins at 25 µg per lane.
Secondary
All lanes : HRP Goat Anti-Rabbit IgG (H+L)
Developed using the ECL technique.
Predicted band size: 16 kDa
Exposure time: 60 secondsBlocking buffer: 3% nonfat dry milk in TBST.
数据表及文件
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SDS download
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Datasheet download
文献 (17)
ab180649 被引用在 17 文献中.
- Wang C et al. The KLF7/PFKL/ACADL axis modulates cardiac metabolic remodelling during cardiac hypertrophy in male mice. Nat Commun 14:959 (2023). PubMed: 36810848
- Li RJ et al. Rhein ameliorates transverse aortic constriction-induced cardiac hypertrophy via regulating STAT3 and p38 MAPK signaling pathways. Front Pharmacol 13:940574 (2022). PubMed: 36091816
- Chen F et al. MALAT1 regulates hypertrophy of cardiomyocytes by modulating the miR-181a/HMGB2 pathway. Eur J Histochem 66:N/A (2022). PubMed: 35726535
- Xu JJ et al. Loganin Inhibits Angiotensin II-Induced Cardiac Hypertrophy Through the JAK2/STAT3 and NF-?B Signaling Pathways. Front Pharmacol 12:678886 (2021). PubMed: 34194329
- Wu QR et al. High glucose induces Drp1-mediated mitochondrial fission via the Orai1 calcium channel to participate in diabetic cardiomyocyte hypertrophy. Cell Death Dis 12:216 (2021). PubMed: 33637715