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AB185679

Anti-NALP5抗体

Anti-NALP5 antibody

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(2 Publications)

Rabbit Polyclonal NALP5 antibody. Suitable for IHC-P and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human NLRP5 aa 350-550.

查看别名

MATER, NALP5, NLRP5, Mater protein homolog, Maternal Antigen that Embryos Require

1 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-NALP5 antibody (AB185679)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-NALP5 antibody (AB185679)

Immunohistochemical analysis of paraffin-embedded Human ovary tissue labeling NALP5 with ab185679 at 1/500 dilution.

关键信息

宿主种属

Rabbit

克隆

Polyclonal

亚型

IgG

不含载体蛋白

No

反应种属

Human

应用

IHC-P

applications

免疫原

Recombinant Fragment Protein within Human NLRP5 aa 350-550. The exact immunogen used to generate this antibody is proprietary information.

P59047

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/500 - 1/1000", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol." } } }
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性能和储存信息

形式
Liquid
纯化工艺
Affinity purification Immunogen
存储溶液
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
运输条件
Blue Ice
推荐的短期储存时间
1-2 weeks
推荐的短期储存条件
+4°C
推荐的长期储存条件
-20°C
分装信息
Upon delivery aliquot
储存信息
Avoid freeze / thaw cycle
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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

NALP5 also known as NLRP5 or Mater is a member of the NOD-like receptor (NLR) family and has significant mechanical functions in cellular processes. The protein weighs approximately 136 kDa and is mainly expressed in oocytes and early embryos in mammals. Its primary role involves regulation of the innate immune response by detecting intracellular threats and forming inflammasomes. NALP5 contains several important domains including the pyrin domain (PYD) NACHT and leucine-rich repeat domain which contribute to its function in cellular defense mechanisms.
Biological function summary

NALP5 plays critical roles in early embryonic development and successful reproduction. It acts as part of the multiprotein complex known as the inflammasome which is essential for the activation of inflammatory cytokines such as IL-1β. This protein is important for oocyte maturation and early embryogenesis impacting fertility and successful pregnancy outcomes. In the developmental context alterations in the function of NALP5 can affect embryonic cell survival and overall developmental competence.

Pathways

NALP5 is integral in facilitating inflammasome assembly and subsequent activation of inflammatory pathways. It significantly influences the immune response modulation through pathways like the NF-kB signaling pathway. Furthermore NALP5 interacts with proteins such as ASC (apoptosis-associated speck-like protein) to mediate cytokine maturation and inflammation. This protein also connects with caspase-1 a critical component necessary for inflammasome function and cytokine activation.

NALP5 relates directly to autoimmune diseases and reproductive disorders. Altered expression or mutations in NALP5 can result in female infertility and have been studied in the context of autoimmune abnormalities. The protein connects to various disease-associated proteins such as NALP3 and other inflammasome components influencing disease progress in conditions marked by inflammation dysregulation. Understanding the role of NALP5 can therefore provide insights into the pathology of related disorders and open avenues for therapeutic interventions.
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产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:
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靶点信息

Component of the subcortical maternal complex (SCMC), a multiprotein complex that plays a key role in early embryonic development. The SCMC complex is a structural constituent of cytoplasmic lattices, which consist in fibrous structures found in the cytoplasm of oocytes and preimplantation embryos. They are required to store maternal proteins critical for embryonic development, such as proteins that control epigenetic reprogramming of the preimplantation embryo, and prevent their degradation or activation. Required for the localization of cortical granules to the cortex of oocytes, via association with the cortical actin scaffold. Required for cortical actin clearance prior to oocyte exocytosis and prevention of polyspermy. Involved in regulating post-fertilization Ca(2+) release and endoplasmic reticulum storage (ER) storage via regulation of cellular localization. May be involved in the localization of mitochondria to the cytoplasm and perinuclear region in oocytes and early stage embryos, independent of its role in CPL formation.
See full target information NLRP5
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文献 (2)

Recent publications for all applications. Explore the full list and refine your search

Current gene therapy 24:249-263 PubMed37929733

2023

FIGNL1 Promotes Hepatocellular Carcinoma Formation Remodeling ECM-receptor Interaction Pathway Mediated by HMMR.

Applications

Unspecified application

Species

Unspecified reactive species

Jiabei Wang,Linmao Sun,Yao Liu,Yunguang Zhang

The EMBO journal 41:e110815 PubMed35912849

2022

Ex vivo reconstitution of fetal oocyte development in humans and cynomolgus monkeys.

Applications

Unspecified application

Species

Unspecified reactive species

Ken Mizuta,Yoshitaka Katou,Baku Nakakita,Aoi Kishine,Yoshiaki Nosaka,Saki Saito,Chizuru Iwatani,Hideaki Tsuchiya,Ikuo Kawamoto,Masataka Nakaya,Tomoyuki Tsukiyama,Masahiro Nagano,Yoji Kojima,Tomonori Nakamura,Yukihiro Yabuta,Akihito Horie,Masaki Mandai,Hiroshi Ohta,Mitinori Saitou
View all publications
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