AB105324

Anti-NALP5抗体

Name: NALP5抗体 (ab105324)| Abcam中文官网
Brand: Abcam Limited
SKU: AB105324
Price: 4606 CNY
Availability: InStock

Anti-NALP5 antibody

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(2 Publications)

Rabbit Polyclonal NALP5 antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Human NLRP5.

查看别名

MATER, NALP5, NLRP5, Mater protein homolog, Maternal Antigen that Embryos Require

2 Images

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-NALP5 antibody (AB105324)

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-NALP5 antibody (AB105324)

Immunohistochemistry of Human brain tissue with ab105324 at 10 μg/mL.

Immunocytochemistry/ Immunofluorescence - Anti-NALP5 antibody (AB105324)

ICC/IF

Unknown

Immunocytochemistry/ Immunofluorescence - Anti-NALP5 antibody (AB105324)

Immunofluorescence of NALP5 in Human brain tissue with ab105324 at 20 ug/mL.

关键信息

宿主种属

Rabbit

克隆

Polyclonal

亚型

IgG

不含载体蛋白

反应种属

Human

应用

ICC/IF, IHC-P

applications

免疫原

Synthetic Peptide within Human NLRP5. The exact immunogen used to generate this antibody is proprietary information.

P59047

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "<p></p>", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "20 µg/mL", "ICCIF-species-notes": "<p></p>" } } }

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性能和储存信息

形式

Liquid

纯化工艺

Affinity purification Immunogen

存储溶液

pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS

运输条件

Blue Ice

补充信息

This supplementary information is collated from multiple sources and compiled automatically.

NALP5 also known as NLRP5 or Mater is a member of the NOD-like receptor (NLR) family and has significant mechanical functions in cellular processes. The protein weighs approximately 136 kDa and is mainly expressed in oocytes and early embryos in mammals. Its primary role involves regulation of the innate immune response by detecting intracellular threats and forming inflammasomes. NALP5 contains several important domains including the pyrin domain (PYD) NACHT and leucine-rich repeat domain which contribute to its function in cellular defense mechanisms.

Biological function summary

NALP5 plays critical roles in early embryonic development and successful reproduction. It acts as part of the multiprotein complex known as the inflammasome which is essential for the activation of inflammatory cytokines such as IL-1β. This protein is important for oocyte maturation and early embryogenesis impacting fertility and successful pregnancy outcomes. In the developmental context alterations in the function of NALP5 can affect embryonic cell survival and overall developmental competence.

Pathways

NALP5 is integral in facilitating inflammasome assembly and subsequent activation of inflammatory pathways. It significantly influences the immune response modulation through pathways like the NF-kB signaling pathway. Furthermore NALP5 interacts with proteins such as ASC (apoptosis-associated speck-like protein) to mediate cytokine maturation and inflammation. This protein also connects with caspase-1 a critical component necessary for inflammasome function and cytokine activation.

NALP5 relates directly to autoimmune diseases and reproductive disorders. Altered expression or mutations in NALP5 can result in female infertility and have been studied in the context of autoimmune abnormalities. The protein connects to various disease-associated proteins such as NALP3 and other inflammasome components influencing disease progress in conditions marked by inflammation dysregulation. Understanding the role of NALP5 can therefore provide insights into the pathology of related disorders and open avenues for therapeutic interventions.

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产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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靶点信息

As a member of the subcortical maternal complex (SCMC), plays an essential role for zygotes to progress beyond the first embryonic cell divisions via regulation of actin dynamics (By similarity). Required for the formation of F-actin cytoplasmic lattices (CPL) in oocytes, which in turn are responsible for symmetric division of zygotes via the regulation of mitotic spindle formation and positioning (By similarity). Required for the localization of cortical granules to the cortex of oocytes, via association with the cortical actin scaffold (By similarity). Required for cortical actin clearance prior to oocyte exocytosis (By similarity). Involved in regulating post-fertilization Ca(2+) release and endoplasmic reticulum (ER) storage via regulation of ER localization (By similarity). May be involved in the localization of mitochondria to the cytoplasm and perinuclear region in oocytes and early stage embryos, independent of its role in CPL formation (By similarity).

See full target information NLRP5

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文献 (2)

Recent publications for all applications. Explore the full list and refine your search

Cell 186:5308-5327.e25 PubMed37922900

2023

Mammalian oocytes store proteins for the early embryo on cytoplasmic lattices.

Applications

Unspecified application

Species

Unspecified reactive species

Ida M A Jentoft,Felix J B Bäuerlein,Luisa M Welp,Benjamin H Cooper,Arsen Petrovic,Chun So,Sarah Mae Penir,Antonio Z Politi,Yehor Horokhovskyi,Iina Takala,Heike Eckel,Rüdiger Moltrecht,Peter Lénárt,Tommaso Cavazza,Juliane Liepe,Nils Brose,Henning Urlaub,Rubén Fernández-Busnadiego,Melina Schuh

Proceedings of the National Academy of Sciences of the United States of America 119:e2203628119 PubMed36201541

2022

Succinyl-CoA-based energy metabolism dysfunction in chronic heart failure.

Applications

Unspecified application

Species

Unspecified reactive species

Shingo Takada,Satoshi Maekawa,Takaaki Furihata,Naoya Kakutani,Daiki Setoyama,Koji Ueda,Hideo Nambu,Hikaru Hagiwara,Haruka Handa,Yoshizuki Fumoto,Soichiro Hata,Tomoka Masunaga,Arata Fukushima,Takashi Yokota,Dongchon Kang,Shintaro Kinugawa,Hisataka Sabe

View all publications

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Anti-NALP5抗体

Anti-NALP5 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-NALP5 antibody (AB105324)

Immunocytochemistry/ Immunofluorescence - Anti-NALP5 antibody (AB105324)