Anti-NALP12/NLRP12抗体(ab105409)
Key features and details
- Rabbit polyclonal to NALP12/NLRP12
- Suitable for: WB, IHC-P
- Reacts with: Human
- Isotype: IgG
概述
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产品名称
Anti-NALP12/NLRP12抗体
参阅全部 NALP12/NLRP12 一抗 -
描述
兔多克隆抗体to NALP12/NLRP12 -
宿主
Rabbit -
经测试应用
适用于: WB, IHC-Pmore details -
种属反应性
与反应: Human -
免疫原
Synthetic peptide corresponding to Human NALP12/NLRP12 (N terminal).
Database link: P59046 -
阳性对照
- WB: Human brain tissue lysate.
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常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Store at +4°C. -
存储溶液
pH: 7.2
Preservative: 0.02% Sodium azide
Constituent: PBS -
Concentration information loading... -
纯度
Immunogen affinity purified -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab105409于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度；实际最佳的稀释度/浓度应由使用者检定。
| 应用 | Ab评论 | 说明 |
|---|---|---|
| WB |
Use a concentration of 1 - 2 µg/ml. Predicted molecular weight: 120 kDa.
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| IHC-P |
Use at an assay dependent concentration.
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| 说明 |
|---|
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WB
Use a concentration of 1 - 2 µg/ml. Predicted molecular weight: 120 kDa. |
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IHC-P
Use at an assay dependent concentration. |
靶标
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功能
May mediate activation of CASP1 via ASC and promote activation of NF-kappa-B via IKK. -
组织特异性
Detected only in peripheral blood leukocytes, predominantly in eosinophils and granulocytes, and at lower levels in monocytes. -
疾病相关
Defects in NLRP12 are the cause of familial cold autoinflammatory syndrome type 2 (FCAS2) [MIM:611762]. FCAS are rare autosomal dominant systemic inflammatory diseases characterized by episodes of rash, arthralgia, fever and conjunctivitis after generalized exposure to cold. -
序列相似性
Belongs to the NLRP family.
Contains 1 DAPIN domain.
Contains 8 LRR (leucine-rich) repeats.
Contains 1 NACHT domain. -
细胞定位
Cytoplasm. - Information by UniProt
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数据库链接
- Entrez Gene: 91662 Human
- Omim: 609648 Human
- SwissProt: P59046 Human
- Unigene: 631573 Human
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别名
- CLR19.3 antibody
- FCAS2 antibody
- Monarch 1 antibody
see all
图片
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-NALP12/NLRP12 antibody (ab105409)
Immunofluorescence of NALP12/NLRP12 in Human brain tissue with ab105409 at 20 ug/mL.
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-NALP12/NLRP12 antibody (ab105409)Immunohistochemistry of Human brain tissue with ab105409 5 μg/mL.
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Western blot - Anti-NALP12/NLRP12 antibody (ab105409)Anti-NALP12/NLRP12 antibody (ab105409) at 1 µg/ml + Human brain tissue lysate at 15 µg
Predicted band size: 120 kDa
实验方案
数据表及文件
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SDS download
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Datasheet download
文献 (3)
ab105409 被引用在 3 文献中.
- Kuang W et al. Inhibited Expression of NLRP12 Promotes the Development of Triple-Negative Breast Cancer by Activating the NF-κB Pathway. Cell Biochem Biophys 81:727-735 (2023). PubMed: 37658975
- Li X et al. A Novel Role for the Regulatory Nod-Like Receptor NLRP12 in Anti-Dengue Virus Response. Front Immunol 12:744880 (2021). PubMed: 34956178
- Shen M & Meng L Peripheral blood miR-372 as a biomarker for ulcerative colitis via direct targeting of NLRP12. Exp Ther Med 18:1486-1492 (2019). PubMed: 31363381