重组Anti-NAK/TBK1抗体[S01-1G3] (ab317376)
![Western blot - Anti-NAK/TBK1 Antibody [S01-1G3] (ab317376)](https://www.abcam.cn/ps/products/317/ab317376/Images/ab317376-536451-anti-nak-tbk1-antibody-s01-1g3-western-blot-jurkat-c6-chok1-hela-human-rat-chinese-hamster.jpg "Western blot - Anti-NAK/TBK1 Antibody [S01-1G3] (ab317376)")
Key features and details
- Produced recombinantly (animal-free) for high batch-to-batch consistency and long term security of supply
- Rabbit monoclonal [S01-1G3] to NAK/TBK1
- Suitable for: WB
- Reacts with: Rat, Human, Chinese hamster
概述
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产品名称
Anti-NAK/TBK1抗体[S01-1G3]
参阅全部 NAK/TBK1 一抗 -
描述
兔单克隆抗体[S01-1G3] to NAK/TBK1 -
宿主
Rabbit -
经测试应用
适用于: WBmore details -
种属反应性
与反应: Rat, Human, Chinese hamster -
免疫原
Synthetic peptide corresponding to Human NAK/TBK1.
Database link: Q9UHD2 -
阳性对照
- WB: Jurkat, C6, CHO-K1 and HeLa cell lysate.
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle. -
存储溶液
pH: 7.4
Preservative: 0.01% Sodium azide
Constituents: 55.08% Water, 40% Glycerol (glycerin, glycerine), 0.98% Tris glycine, 0.88% Sodium chloride, 0.05% BSA -
Concentration information loading... -
纯度
Affinity purified -
克隆
单克隆 -
克隆编号
S01-1G3 -
同种型
IgG -
研究领域
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab317376于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度；实际最佳的稀释度/浓度应由使用者检定。
| 应用 | Ab评论 | 说明 |
|---|---|---|
| WB |
1/1000. Predicted molecular weight: 84 kDa.
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| 说明 |
|---|
|
WB
1/1000. Predicted molecular weight: 84 kDa. |
靶标
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功能
Serine/threonine protein involved in the signaling cascade converging to the activation of the transcription factor NF-kappa-B. May function as an IKK kinase, playing an essential role in the transcription of a subset of TNF-alpha-induced genes. Also mediates production of RANTES/CCL5 and interferon-beta/IFNB1. Has a pivotal role in the innate immune response. Phosphorylates Borna disease virus (BDV) P protein. Phosphorylates and activates IRF3 and IRF7 and allows their nuclear localization. This leads to production of alpha/beta interferons and the development of a cellular antiviral state. It also seems to be a central factor in the induction of the antiviral interferon response. Inhibition of its interaction with IRF3, due to HCV NS3 binding or BDV P protein seems to be one mechanism of inhibition of the innate immune responses of hepatitis C virus (HCV) infection or Borna disease virus infection respectively. -
组织特异性
Ubiquitous with higher expression in testis. -
序列相似性
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. I-kappa-B kinase subfamily.
Contains 1 protein kinase domain. -
细胞定位
Cytoplasm. - Information by UniProt
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数据库链接
- Entrez Gene: 29110 Human
- Entrez Gene: 299827 Rat
- Omim: 604834 Human
- SwissProt: Q9UHD2 Human
- Unigene: 505874 Human
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别名
- EC 2.7.11.1 antibody
- FLJ11330 antibody
- FTDALS4 antibody
see all
图片
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Western blot - Anti-NAK/TBK1 Antibody [S01-1G3] (ab317376)All lanes : Anti-NAK/TBK1 Antibody [S01-1G3] (ab317376) at 1/1000 dilution
Lane 1 : Jurkat cell lysate
Lane 2 : C6 cell lysate
Lane 3 : CHO-K1 cell lysate
Lane 4 : HeLa cell lysate
Predicted band size: 84 kDa
实验方案
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
数据表及文件
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SDS download
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Datasheet download
文献 (0)
ab317376 尚未被引用在任何文献中。