AB174286

重组Anti-MYO19抗体[EPR12551-13]

Name: MYO19抗体[EPR12551-13] (ab174286)| Abcam中文官网
Brand: Abcam Limited
SKU: AB174286
Price: 2515 CNY
Availability: InStock
Rating: 5 (1 reviews)

Anti-MYO19 antibody [EPR12551-13]

RabMAb
Recombinant
了解详情

(1 Review)

(7 Publications)

Rabbit Recombinant Monoclonal MYO19 antibody. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 7 publications.

查看别名

MYOHD1, MYO19, Unconventional myosin-XIX, Myosin head domain-containing protein 1

2 Images

Immunocytochemistry/ Immunofluorescence - Anti-MYO19 antibody [EPR12551-13] (AB174286)

ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-MYO19 antibody [EPR12551-13] (AB174286)

Immunofluorescent analysis of A549 cells labeling MYO19 with ab174286 at 1/50 (red). DAPI nuclear staining (blue).

Supplier Data

Western blot - Anti-MYO19 antibody [EPR12551-13] (AB174286)

All lanes:

Western blot - Anti-MYO19 antibody [EPR12551-13] (ab174286) at 1/1000 dilution

Lane 1:

HeLa cell line lysate at 10 µg

Lane 2:

A549 cell line lysate at 10 µg

Lane 3:

K562 cell line lysate at 10 µg

Lane 4:

293T cell line lysate at 10 µg

Secondary

All lanes:

Goat anti-rabbit HRP conjugated antibody at 1/500 dilution

Predicted band size: 109 kDa

true

不同偶联物与剂型 (1)

Carrier free

Anti-MYO19 antibody [EPR12551-13] - BSA and Azide free

关键信息

宿主种属

Rabbit

克隆

Monoclonal

克隆号

EPR12551-13

亚型

IgG

不含载体蛋白

反应种属

Human

应用

ICC/IF, WB

applications

免疫原

The exact immunogen used to generate this antibody is proprietary information.

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IP" : {"fullname" : "Immunoprecipitation", "shortname":"IP"}, "IHC" : {"fullname" : "Immunohistochemistry", "shortname":"IHC"}, "FlowCyt" : {"fullname" : "Flow Cytometry", "shortname":"Flow Cyt"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IP-species-checked": "notRecommended", "IP-species-dilution-info": "", "IP-species-notes": "", "IHC-species-checked": "notRecommended", "IHC-species-dilution-info": "", "IHC-species-notes": "", "FlowCyt-species-checked": "notRecommended", "FlowCyt-species-dilution-info": "", "FlowCyt-species-notes": "", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000 - 1/10000", "WB-species-notes": "", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "1/50 - 1/100", "ICCIF-species-notes": "" } } }

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产品详情

Species reactivity
Mouse, Rat: We have preliminary internal testing data to indicate this antibody may not react with these species.
Please contact us for more information.

Patented technology
Our RabMAb^® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb^® patents.

What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:

- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production

For more information, read more on recombinant antibodies.

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性能和储存信息

形式

Liquid

纯化工艺

Affinity purification Protein A

存储溶液

pH: 7.2 - 7.4 Preservative: 0.01% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA

运输条件

Conditional Ambient

分装信息

Upon delivery aliquot

储存信息

Avoid freeze / thaw cycle

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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

The MYO19 protein also known as Myosin XIX functions as an ATP-dependent motor protein. It possesses a molecular mass of approximately 119 kDa and is part of the myosin superfamily. This protein is known for its role in cellular processes requiring motility including vesicle and organelle transport. MYO19 is widely expressed in tissues with notable expression in the brain and skeletal muscles suggesting its importance in those regions.

Biological function summary

MYO19 contributes to mitochondrial dynamics by participating in mitochondrial motility and positioning within cells. While MYO19 is not part of a larger protein complex it interacts with the mitochondrial outer membrane and aids in tethering mitochondria to the cytoskeleton. This interaction is essential for maintaining proper cellular function specifically in energy-demanding tissues.

Pathways

MYO19 interacts with cellular transport mechanisms notably involving the actin cytoskeleton pathway. The protein facilitates mitochondrial movement along actin filaments. It shares pathways with other myosin family members such as MYO5 which are involved in intracellular transport. Additionally MYO19's role in actin-related pathways underlines its involvement in regulating cellular energy distribution and homeostasis.

MYO19 has potential links with neurodegenerative diseases and muscular disorders. Disruption in MYO19 function may lead to impaired mitochondrial distribution contributing to the pathology of conditions like amyotrophic lateral sclerosis (ALS). Additionally the protein shows possible connections with neurofilament-associated proteins suggesting a role in neural health. Such associations highlight the significance of MYO19 in understanding disease mechanisms and designing therapeutic strategies.

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产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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靶点信息

Actin-based motor molecule with ATPase activity that localizes to the mitochondrion outer membrane (PubMed : 19932026, PubMed : 23568824, PubMed : 25447992). Motor protein that moves towards the plus-end of actin filaments (By similarity). Required for mitochondrial inheritance during mitosis (PubMed : 25447992). May be involved in mitochondrial transport or positioning (PubMed : 23568824).

See full target information MYO19

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文献 (7)

Recent publications for all applications. Explore the full list and refine your search

European journal of medical research 30:765 PubMed40830974

2025

Coordinating oncogenesis and immune evasion: KPNA2, GOLM1, and TK1 as novel CAR T-cell targets in lung adenocarcinoma.

Applications

Unspecified application

Species

Unspecified reactive species

Wangrui Liu,Hui Zou,Lei Guo,Zhonghua Zhou,Yahui Xie,Huaqi Guo,Gang Wei,Kai Zhang,Hui Yin,Shiyin Wei,Jiachang Chi

Journal of cell science 136: PubMed36744380

2023

Myo19 tethers mitochondria to endoplasmic reticulum-associated actin to promote mitochondrial fission.

Applications

Unspecified application

Species

Unspecified reactive species

Stephen M Coscia,Cameron P Thompson,Qing Tang,Elana E Baltrusaitis,Joseph A Rhodenhiser,Omar A Quintero-Carmona,E Michael Ostap,Melike Lakadamyali,Erika L F Holzbaur

Journal of cell science 134: PubMed34013964

2021

Coordination of mitochondrial and cellular dynamics by the actin-based motor Myo19.

Applications

Unspecified application

Species

Unspecified reactive species

Katarzyna Majstrowicz,Ulrike Honnert,Petra Nikolaus,Vera Schwarz,Stefanie J Oeding,Sandra A Hemkemeyer,Martin Bähler

Nature 591:659-664 PubMed33658713

2021

Actin cables and comet tails organize mitochondrial networks in mitosis.

Applications

Unspecified application

Species

Unspecified reactive species

Andrew S Moore,Stephen M Coscia,Cory L Simpson,Fabian E Ortega,Eric C Wait,John M Heddleston,Jeffrey J Nirschl,Christopher J Obara,Pedro Guedes-Dias,C Alexander Boecker,Teng-Leong Chew,Julie A Theriot,Jennifer Lippincott-Schwartz,Erika L F Holzbaur

Journal of cell science 131: PubMed30111583

2018

Identification of Miro1 and Miro2 as mitochondrial receptors for myosin XIX.

Applications

Unspecified application

Species

Unspecified reactive species

Stefanie J Oeding,Katarzyna Majstrowicz,Xiao-Ping Hu,Vera Schwarz,Angelika Freitag,Ulrike Honnert,Petra Nikolaus,Martin Bähler

Scientific reports 7:11577 PubMed28912530

2017

ROS induced distribution of mitochondria to filopodia by Myo19 depends on a class specific tryptophan in the motor domain.

Applications

Unspecified application

Species

Unspecified reactive species

Boris I Shneyer,Marko Ušaj,Naama Wiesel-Motiuk,Ronit Regev,Arnon Henn

Journal of cell science 129:543-56 PubMed26659663

2015

Myo19 is an outer mitochondrial membrane motor and effector of starvation-induced filopodia.

Applications

Unspecified application

Species

Unspecified reactive species

Boris I Shneyer,Marko Ušaj,Arnon Henn

View all publications

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Abcam Product Promise

我们致力于为您的研究提供高质量的试剂，为您科研的每一步提供支持。若我们的产品未能达到预期性能，我们向您提供 Abcam Product Promise 保障。

详情请参阅我们的条款与条件。

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

重组Anti-MYO19抗体[EPR12551-13]