Anti-Myeloperoxidase抗体[8F4] (ab16886)
![Flow Cytometry (Intracellular) - Anti-Myeloperoxidase antibody [8F4] (ab16886)](https://www.abcam.cn/ps/products/16/ab16886/Images/ab16886-282316-anti-myeloperoxidase-antibody-8f4-flow-cytometry.jpg "Flow Cytometry (Intracellular) - Anti-Myeloperoxidase antibody [8F4] (ab16886)")
Key features and details
- Mouse monoclonal [8F4] to Myeloperoxidase
- Suitable for: Flow Cyt (Intra)
- Reacts with: Mouse
- Isotype: IgG1
概述
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产品名称
Anti-Myeloperoxidase抗体[8F4]
参阅全部 Myeloperoxidase 一抗 -
描述
小鼠单克隆抗体[8F4] to Myeloperoxidase -
宿主
Mouse -
经测试应用
适用于: Flow Cyt (Intra)more details -
种属反应性
与反应: Mouse
预测可用于: Rat
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免疫原
Tissue, cells or virus corresponding to Mouse Myeloperoxidase.
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阳性对照
- Neutrophils isolated from digested infarcts Flow Cyt (Intra): Wehi3BD+ cells.
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常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Upon delivery aliquot. Store at +4°C. Avoid freeze / thaw cycle. -
存储溶液
Preservative: 0.02% Sodium azide
Constituents: PBS, 0.1% BSA -
Concentration information loading... -
纯化说明
0.2 µm filtered -
克隆
单克隆 -
克隆编号
8F4 -
同种型
IgG1 -
研究领域
相关产品
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Assay kits
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Compatible Secondaries
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Isotype control
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Recombinant Protein
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab16886于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度；实际最佳的稀释度/浓度应由使用者检定。
| 应用 | Ab评论 | 说明 |
|---|---|---|
| Flow Cyt (Intra) |
1/10.
ab170190 - Mouse monoclonal IgG1, is suitable for use as an isotype control with this antibody. |
| 说明 |
|---|
|
Flow Cyt (Intra)
1/10. ab170190 - Mouse monoclonal IgG1, is suitable for use as an isotype control with this antibody. |
靶标
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功能
Part of the host defense system of polymorphonuclear leukocytes. It is responsible for microbicidal activity against a wide range of organisms. In the stimulated PMN, MPO catalyzes the production of hypohalous acids, primarily hypochlorous acid in physiologic situations, and other toxic intermediates that greatly enhance PMN microbicidal activity. -
疾病相关
Defects in MPO are the cause of myeloperoxidase deficiency (MPD) [MIM:254600]. MPD is an autosomal recessive defect that results in disseminated candidiasis. -
序列相似性
Belongs to the peroxidase family. XPO subfamily. -
细胞定位
Lysosome. - Information by UniProt
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数据库链接
- Entrez Gene: 17523 Mouse
- Entrez Gene: 303413 Rat
- SwissProt: P11247 Mouse
- Unigene: 4668 Mouse
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别名
- 84 kDa myeloperoxidase antibody
- 89 kDa myeloperoxidase antibody
- EC 1.11.1.7 antibody
see all
图片
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Flow Cytometry (Intracellular) - Anti-Myeloperoxidase antibody [8F4] (ab16886)
Detection of MPO in Wehi3BD+ cells. Red, black and blue line represent the isotype control, cells only and ab16886 at 10 μg/ml, respectively.
实验方案
数据表及文件
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Datasheet download
文献 (5)
ab16886 被引用在 5 文献中.
- Díaz-Godínez C et al. New Insights on NETosis Induced by Entamoeba histolytica: Dependence on ROS from Amoebas and Extracellular MPO Activity. Antioxidants (Basel) 10:N/A (2021). PubMed: 34206992
- Roth Flach RJ et al. Myeloperoxidase inhibition in mice alters atherosclerotic lesion composition. PLoS One 14:e0214150 (2019). PubMed: 30889221
- Chu TH et al. Hepatoma-derived growth factor participates in Helicobacter Pylori-induced neutrophils recruitment, gastritis and gastric carcinogenesis. Oncogene 38:6461-6477 (2019). PubMed: 31332288
- Lu SM et al. HIV-1 Tat-Induced Microgliosis and Synaptic Damage via Interactions between Peripheral and Central Myeloid Cells. PLoS One 6:e23915 (2011). IHC-FoFr ; Mouse . PubMed: 21912650
- Salguero Palacios R et al. Activation of hepatic stellate cells is associated with cytokine expression in thioacetamide-induced hepatic fibrosis in mice. Lab Invest 88:1192-203 (2008). IHC-Fr ; Mouse . PubMed: 18794850
