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AB28541

Anti-Myelin Basic蛋白抗体

Anti-Myelin Basic Protein antibody

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(2 Publications)

Rabbit Polyclonal Myelin Basic Protein antibody. Suitable for sELISA and reacts with Pig samples. Cited in 2 publications. Immunogen corresponding to Native Full Length Protein corresponding to Cow MBP.

查看别名

Myelin basic protein, MBP

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Sandwich ELISA - Anti-Myelin Basic Protein antibody (AB28541)
  • sELISA

Unknown

Sandwich ELISA - Anti-Myelin Basic Protein antibody (AB28541)

Fixed Immobilized Anti-MBP (ab28541) : 2 ug/mL, 100 ul/well
Captured Antigen : Swine MBP , range from 1 to 90 ng/mL
Detection : anti-MBP HRP (ab77895), 0.25 ug/mL in 1% BSA and PBSt

Sandwich ELISA - Anti-Myelin Basic Protein antibody (AB28541)
  • sELISA

Unknown

Sandwich ELISA - Anti-Myelin Basic Protein antibody (AB28541)

Immobilized Anti-MBP (ab28541) : range from 0.125 to 2 μg/ml, 100 μl/well
Fixed Captured Antigen : Swine MBP, 500 ng/mL
Detection : anti-MBP HRP (ab77895), 0.25 ug/mL in 1% BSA and PBSt

关键信息

宿主种属

Rabbit

克隆

Polyclonal

亚型

IgG

不含载体蛋白

No

反应种属

Pig

应用

sELISA

applications

免疫原

Native Full Length Protein corresponding to Cow MBP.

P02687

特异性

This antibody is specific to myelin basic proteins. It may cross react with other isoforms of myelin basic proteins.

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "sELISA" : {"fullname" : "Sandwich ELISA", "shortname":"sELISA"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Mammals": { "sELISA-species-checked": "predicted", "sELISA-species-dilution-info": "", "sELISA-species-notes": "" }, "Pig": { "sELISA-species-checked": "testedAndGuaranteed", "sELISA-species-dilution-info": "", "sELISA-species-notes": "<p>To be used as capture antibody. Pair with <a href='/products/primary-antibodies/hrp-myelin-basic-protein-antibody-ab77895'>ab77895</a> - Rabbit polyclonal to Myelin Basic Protein (HRP)</p>" } } }
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您是否考虑以下替代产品？

AB133620

Anti-Myelin Basic Protein antibody [EPR6652]

5
5 Reviews
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为什么推荐这个？

为向您提供最高品质的产品，我们在不断升级产品范围。我们选择了这个替代产品供您参考，因为它提供了更好的性能，更容易和更方便的使用，或交期更快。

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性能和储存信息

形式
Liquid
纯化说明
The antibody was affinity purified on agarose with an immuno dominant peptide (PRTPPPSQGKGRGL), which is a universal peptide sequence for all isoforms of mammalian myelin basic proteins.
存储溶液
pH: 6 - 8 Preservative: 0.01% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine), 0.01% Ammonium Acetate
运输条件
Blue Ice
推荐的短期储存条件
+4°C
推荐的长期储存条件
-20°C
分装信息
Upon delivery aliquot
储存信息
Avoid freeze / thaw cycle
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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

The myelin basic protein also referred to as MBP or MBP protein plays an important mechanical role in the central nervous system. It is a major component in the formation and stability of the myelin sheath which wraps around nerve fibers to ensure efficient neural signaling. The molecular weight of MBP can vary due to alternative splicing; one common form has a mass of about 18.5 kDa. MBP is expressed predominantly in oligodendrocytes within the brain and spinal cord where it helps form the myelin sheath. MBP2 is another variant that may be mentioned in some contexts.
Biological function summary

MBP is not just a passive structural element; it binds and interacts with lipids and other proteins to maintain the compact structure of the myelin sheath. MBP forms part of a complex that includes various other proteins and lipids ensuring the stability and function of myelin. Misfolding or altered expression of MBP can compromise myelin integrity affecting the insulation of neural pathways and signal transmission.

Pathways

MBP is an essential component in the pathways of myelination and neural plasticity. It plays a role in the signaling pathways that stimulate the development and maintenance of the myelin sheath. The protein interacts with other elements of the myelin sheath such as proteolipid protein (PLP) and myelin-associated glycoprotein (MAG) to coordinate its formation and repair processes.

MBP is linked closely to multiple sclerosis (MS) and other demyelinating conditions. Damage to or autoimmunity against MBP leads to the degradation of the myelin sheath contributing to the neurological symptoms in MS. The protein interacts with elements of the immune system with autoantibodies targeting MBP often found in MS patients. Another disorder associated with MBP dysfunction is Charcot-Marie-Tooth disease where abnormal MBP expression and structure can impact nerve function.
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产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:
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靶点信息

Is, with PLP, the most abundant protein component of the myelin membrane in the CNS. Has a role in both the formation and stabilization of this compact multilayer arrangement of bilayers. Each splice variant and charge isomer may have a specialized function in the assembly of an optimized, biochemically functional myelin membrane (By similarity).
See full target information MBP
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文献 (2)

Recent publications for all applications. Explore the full list and refine your search

Scientific reports 13:19529 PubMed37945646

2023

Artificial axons as a biomimetic 3D myelination platform for the discovery and validation of promyelinating compounds.

Applications

Unspecified application

Species

Unspecified reactive species

Anna Jagielska,Kristin Radzwill,Daniela Espinosa-Hoyos,Mingyu Yang,Kavin Kowsari,Jonathan E Farley,Stefanie Giera,Ann Byrne,Guoqing Sheng,Nicholas X Fang,James C Dodge,Carlos E Pedraza,Krystyn J Van Vliet

Reproductive sciences (Thousand Oaks, Calif.) 29:1296-1304 PubMed34462873

2021

Identification of Adrenomedullin-Induced S-Nitrosylated Proteins in JEG-3 Placental Cells.

Applications

Unspecified application

Species

Unspecified reactive species

Yingting Li,Liuying Zhong,Cheuk-Lun Lee,Philip C N Chiu,Min Chen
View all publications
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详情请参阅我们的条款与条件。
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