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AB77098

Anti-Muscarinic Acetylcholine Receptor 1/CHRM1抗体

Anti-Muscarinic Acetylcholine Receptor 1/CHRM1 antibody

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(6 Publications)

Goat Polyclonal Muscarinic Acetylcholine Receptor 1/CHRM1 antibody. Suitable for WB and reacts with Human samples. Cited in 6 publications. Immunogen corresponding to Synthetic Peptide within Human CHRM1 aa 400 to C-terminus.

查看别名

Muscarinic acetylcholine receptor M1, CHRM1

关键信息

宿主种属

Goat

克隆

Polyclonal

亚型

IgG

不含载体蛋白

No

反应种属

Human

应用

WB

applications

免疫原

Synthetic Peptide within Human CHRM1 aa 400 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

P11229

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搭配使用产品

Primary Antibodies

AB189432

Anti-Muscarinic Acetylcholine Receptor M4/CHRM4 antibody

Immunocytochemistry/ Immunofluorescence - Anti-Muscarinic Acetylcholine Receptor M4/CHRM4 antibody (AB189432)

  • 0
  • 0
Primary Antibodies

AB2805

Anti-Muscarinic Acetylcholine Receptor 2/CM2 antibody [31-1D1]

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Muscarinic Acetylcholine Receptor 2/CM2 antibody [31-1D1] (AB2805)

  • 3
  • 7
Primary Antibodies

AB281588

Anti-MAP2 antibody [RM1010] - Neuronal Marker

RabMAb|Recombinant|Lab Essentials|20ul selling size

Flow Cytometry (Intracellular) - Anti-MAP2 antibody [RM1010] - Neuronal Marker (AB281588)

  • 0
  • 0
Primary Antibodies

AB316220

Anti-Parvalbumin antibody [RM1120]

BOND RX™ Validated|20ul selling size|Recombinant|RabMAb

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Parvalbumin antibody [RM1120] (AB316220)

  • 0
  • 0
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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.3-1 µg/mL", "WB-species-notes": "<p>1 hour primary incubation is recommended for this product.</p>" }, "Mouse": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Rat": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Dog": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Orangutan": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Pig": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Rhesus monkey": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" } } }
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性能和储存信息

形式
Liquid
纯化工艺
Affinity purification Immunogen
纯化说明
ab77098 is purified from goat serum by ammonium sulphate precipitation, followed by antigen affinity chromatography using the immunizing peptide.
存储溶液
pH: 7.3 Preservative: 0.02% Sodium azide Constituents: Tris buffered saline, 0.5% BSA
运输条件
Blue Ice
推荐的短期储存条件
+4°C
推荐的长期储存条件
-20°C
分装信息
Upon delivery aliquot
储存信息
Avoid freeze / thaw cycle
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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

The Muscarinic Acetylcholine Receptor 1 (CHRM1) is a G protein-coupled receptor that plays an important role in transmitting acetylcholine-mediated cholinergic signals. It also goes by the names 'M1 receptor' or 'muscarinic acetylcholine receptors'. The protein has a mass of approximately 51 kDa and is largely expressed in the central nervous system particularly in the cerebral cortex and hippocampus. Its activation leads to intracellular signaling cascades involving the modulation of ion channels and influencing cellular responses.
Biological function summary

CHRM1 participates in various neural functions by interacting with acetylcholine. It does not form part of a complex itself but has significant interactions with other proteins particularly in nerve cells influencing cognitive processes and memory. CHRM1 plays an essential role in modulating neurotransmission which affects neuronal excitability and synaptic plasticity contributing to learning and attention processes.

Pathways

CHRM1 is involved in the phosphoinositide pathway and modulation of the MAPK/ERK pathway. The receptor interacts with proteins like Gq and G11 family members during signal transduction. These pathways help mediate the cellular actions initiated by neurotransmitter binding therefore facilitating long-term potentiation and contributing to cognitive function and higher brain activities.

CHRM1 is associated with Alzheimer's disease and schizophrenia. Altered signaling or expression of this receptor often correlates with cognitive decline in Alzheimer's disease suggesting a significant role in neurodegenerative processes. In schizophrenia dysfunctional CHRM1 signaling may impact thought processes and behavioral symptoms. In these contexts CHRM1 is connected to proteins such as beta-amyloid in Alzheimer's and dopamine receptors in schizophrenia pointing to its relevance in these conditions' molecular pathology.
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产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:
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靶点信息

The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover.
See full target information CHRM1
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文献 (6)

Recent publications for all applications. Explore the full list and refine your search

The Journal of neuroscience : the official journal of the Society for Neuroscience 44: PubMed38719447

2024

Neuroanatomical Substrates of Circuit-Specific Cholinergic Modulation across the Primate Anterior Cingulate Cortex.

Applications

Unspecified application

Species

Unspecified reactive species

Alexandra Tsolias,Yuxin Zhou,Chromewell A Mojica,Mitali Sakharkar,Marianna Z Tsolias,Tara L Moore,Douglas L Rosene,Maria Medalla

Communications biology 7:3 PubMed38168628

2024

Activation of M1 cholinergic receptors in mouse somatosensory cortex enhances information processing and detection behaviour.

Applications

Unspecified application

Species

Unspecified reactive species

Wricha Mishra,Ehsan Kheradpezhouh,Ehsan Arabzadeh

Life science alliance 7: PubMed38056909

2023

IMPA1 dependent regulation of phosphatidylinositol 4,5-bisphosphate and calcium signalling by lithium.

Applications

Unspecified application

Species

Unspecified reactive species

Sankhanil Saha,Harini Krishnan,Padinjat Raghu

Frontiers in neural circuits 15:795325 PubMed35087381

2022

Muscarinic Acetylcholine Receptor Localization on Distinct Excitatory and Inhibitory Neurons Within the ACC and LPFC of the Rhesus Monkey.

Applications

Unspecified application

Species

Unspecified reactive species

Alexandra Tsolias,Maria Medalla

Investigative ophthalmology & visual science 62:19 PubMed34546325

2021

Novel Insights Into Muscarinic and Purinergic Responses in Primary Cultures of Rat Lacrimal Gland Myoepithelial Cells.

Applications

Unspecified application

Species

Unspecified reactive species

Martin Dankis,Thomas Carlsson,Patrik Aronsson,Gunnar Tobin,Michael Winder

Basic & clinical pharmacology & toxicology 121:257-265 PubMed28437032

2017

Autonomic Receptor-mediated Regulation of Production and Release of Nitric Oxide in Normal and Malignant Human Urothelial Cells.

Applications

Unspecified application

Species

Unspecified reactive species

Michael Winder,Renata Vesela,Patrik Aronsson,Bhavik Patel,Thomas Carlsson
View all publications
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