Anti-MURF2抗体(ab4387)
Key features and details
- Goat polyclonal to MURF2
- Suitable for: WB, IHC-P
- Reacts with: Human
- Isotype: IgG
概述
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产品名称
Anti-MURF2抗体 -
描述
山羊多克隆抗体to MURF2 -
宿主
Goat -
经测试应用
适用于: WB, IHC-Pmore details -
种属反应性
与反应: Human
预测可用于: Rat, Dog, Pig
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免疫原
Synthetic peptide:
HIFSFSWLNSLNE
, corresponding to C terminal amino acids 536-546 of Human MURF2. -
常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles. -
存储溶液
pH: 7.30
Preservative: 0.02% Sodium azide
Constituents: Tris buffered saline, 0.5% BSA -
Concentration information loading... -
纯度
Immunogen affinity purified -
纯化说明
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
应用
| 应用 | Ab评论 | 说明 |
|---|---|---|
| WB |
Use at an assay dependent concentration. Predicted molecular weight: 60 kDa.
|
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| IHC-P |
Use a concentration of 10 µg/ml.
|
| 说明 |
|---|
|
WB
Use at an assay dependent concentration. Predicted molecular weight: 60 kDa. |
|
IHC-P
Use a concentration of 10 µg/ml. |
靶标
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功能
May regulate gene expression and protein turnover in muscle cells. -
组织特异性
Highly expressed in muscle. Low-level expression in liver. -
序列相似性
Contains 1 B box-type zinc finger.
Contains 1 COS domain.
Contains 1 RING-type zinc finger. -
细胞定位
Cytoplasm. Nucleus. Nuclear under atrophic conditions and upon mechanical signals. Localizes to the sarcomeric M-band in cardiomyocytes. Colocalizes in part with microtubules. - Information by UniProt
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数据库链接
- Entrez Gene: 84675 Human
- Entrez Gene: 365751 Rat
- Omim: 606469 Human
- SwissProt: Q9BYV6 Human
- SwissProt: Q5PQN5 Rat
- Unigene: 85524 Human
- Unigene: 76142 Rat
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别名
- MURF 2 antibody
- MURF-2 antibody
- MuRF2 antibody
see all
图片
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Western blot - Anti-MURF2 antibody (ab4387)Anti-MURF2 antibody (ab4387) at 0.1 µg/ml + Human heart lysate (in RIPA buffer) at 35 µg
Predicted band size: 60 kDa
数据表及文件
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Datasheet download
文献 (6)
ab4387 被引用在 6 文献中.
- Müller E et al. E3-ligase knock down revealed differential titin degradation by autopagy and the ubiquitin proteasome system. Sci Rep 11:21134 (2021). PubMed: 34702928
- He J et al. MuRF2 regulates PPAR?1 activity to protect against diabetic cardiomyopathy and enhance weight gain induced by a high fat diet. Cardiovasc Diabetol 14:97 (2015). WB . PubMed: 26242235
- Cullup T et al. Recessive mutations in EPG5 cause Vici syndrome, a multisystem disorder with defective autophagy. Nat Genet 45:83-7 (2013). PubMed: 23222957
- Perera S et al. Developmental regulation of MURF E3 ubiquitin ligases in skeletal muscle. J Muscle Res Cell Motil 33:107-22 (2012). PubMed: 22426552
- Perera S et al. Developmental regulation of MURF ubiquitin ligases and autophagy proteins nbr1, p62/SQSTM1 and LC3 during cardiac myofibril assembly and turnover. Dev Biol 351:46-61 (2011). WB ; Mouse . PubMed: 21185285
- Willis MS et al. Muscle ring finger 1, but not muscle ring finger 2, regulates cardiac hypertrophy in vivo. Circ Res 100:456-9 (2007). WB ; Mouse . PubMed: 17272810
