Anti-MTBP抗体(ab115529)
Key features and details
- Rabbit polyclonal to MTBP
- Suitable for: IHC-P
- Reacts with: Human
- Isotype: IgG
概述
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产品名称
Anti-MTBP抗体 -
描述
兔多克隆抗体to MTBP -
宿主
Rabbit -
经测试应用
适用于: IHC-Pmore details -
种属反应性
与反应: Human
预测可用于: Mouse, Cow, Pig
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免疫原
Synthetic peptide:
GAVECFEEEDSNSRESLS
conjugated to KLH, corresponding to amino acids 122-139 of Human MTBP (NP_071328.2). -
阳性对照
- Human thymus and tonsil tissues.
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常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C or -80°C. Avoid freeze / thaw cycle. -
存储溶液
pH: 7.4
Preservative: 0.02% Sodium azide
Constituent: 99% PBS -
Concentration information loading... -
纯度
Protein A purified -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
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Compatible Secondaries
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Immunizing Peptide (Blocking)
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Isotype control
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab115529于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度；实际最佳的稀释度/浓度应由使用者检定。
| 应用 | Ab评论 | 说明 |
|---|---|---|
| IHC-P |
Use a concentration of 10 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.
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| 说明 |
|---|
|
IHC-P
Use a concentration of 10 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol. |
靶标
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功能
Inhibits cell migration in vitro and suppresses the invasive behavior of tumor cells (By similarity). May play a role in MDM2-dependent p53/TP53 homeostasis in unstressed cells. Inhibits autoubiquitination of MDM2, thereby enhancing MDM2 stability. This promotes MDM2-mediated ubiquitination of p53/TP53 and its subsequent degradation. -
序列相似性
Belongs to the MTBP family. - Information by UniProt
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数据库链接
- Entrez Gene: 27085 Human
- Entrez Gene: 105837 Mouse
- Omim: 605927 Human
- SwissProt: Q96DY7 Human
- SwissProt: Q80VU3 Mouse
- SwissProt: Q8BJS8 Mouse
- SwissProt: Q8BTU9 Mouse
- SwissProt: Q8BTW0 Mouse
see all -
别名
- hMTBP antibody
- MDM 2 binding protein antibody
- MDM 2 BP antibody
see all
图片
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MTBP antibody (ab115529)ab115529 at 10ug/ml staining MTBP in Formalin-fixed, Paraffin-embedded Human thymus tissue by Immunohistochemistry followed by biotinylated secondary antibody, alkaline phosphatase-streptavidin and chromogen.
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MTBP antibody (ab115529)ab115529 at 10ug/ml staining MTBP in Formalin-fixed, Paraffin-embedded Human tonsil tissue by Immunohistochemistry followed by biotinylated secondary antibody, alkaline phosphatase-streptavidin and chromogen.
数据表及文件
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SDS download
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Datasheet download
文献 (3)
ab115529 被引用在 3 文献中.
- Shayimu P et al. MTBP promoted the proliferation, migration and invasion of colon cancer cells by activating the expression of ZEB2. Anim Cells Syst (Seoul) 25:152-160 (2021). PubMed: 34262658
- Song Y et al. MTBP regulates cell survival and therapeutic sensitivity in TP53 wildtype glioblastomas. Theranostics 9:6019-6030 (2019). PubMed: 31534534
- Wang W et al. MDM2 binding protein as a predictor of metastasis and a novel prognostic biomarker in patients with gastric cancer. Oncol Lett 14:6409-6416 (2017). PubMed: 29422956