AB192306

Anti-MT-ND3抗体

Name: MT-ND3抗体 (ab192306)| Abcam中文官网
Brand: Abcam Limited
SKU: AB192306
Price: 4744 CNY
Availability: InStock
Rating: 4 (1 reviews)

Anti-MT-ND3 antibody

(1 Review)

(10 Publications)

Rabbit Polyclonal MT-ND3 antibody. Suitable for WB and reacts with Human, Mouse, Rat samples. Cited in 10 publications. Immunogen corresponding to Synthetic Peptide within Human MT-ND3 aa 1-100.

查看别名

MTND3, NADH3, ND3, MT-ND3, NADH-ubiquinone oxidoreductase chain 3, NADH dehydrogenase subunit 3

1 Images

Supplier Data

Western blot - Anti-MT-ND3 antibody (AB192306)

All lanes:

Western blot - Anti-MT-ND3 antibody (ab192306)

Lane 1:

HEK293T whole cell lysate

Lane 2:

RAW 264.7 whole cell lysate

Lane 3:

H9C2 whole cell lysate

Predicted band size: 13 kDa

false

关键信息

宿主种属

Rabbit

克隆

Polyclonal

亚型

IgG

不含载体蛋白

反应种属

Mouse, Rat, Human

应用

applications

免疫原

Synthetic Peptide within Human MT-ND3 aa 1-100. The exact immunogen used to generate this antibody is proprietary information.

P03897

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/1000", "WB-species-notes": "" }, "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/1000", "WB-species-notes": "" }, "Rat": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/1000", "WB-species-notes": "" } } }

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性能和储存信息

形式

Liquid

纯化工艺

Affinity purification Immunogen

纯化说明

ab192306 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

存储溶液

pH: 7.2 Preservative: 0.05% Sodium azide Constituents: PBS

运输条件

Blue Ice

分装信息

Upon delivery aliquot

储存信息

Avoid freeze / thaw cycle

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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

MT-ND3 also known as NADH-ubiquinone oxidoreductase chain 3 is a subunit of Complex I of the mitochondrial respiratory chain. It operates as part of the first enzyme in the electron transport chain which is important for ATP production. With an approximate molecular mass of 12 kDa MT-ND3 is expressed in the inner mitochondrial membrane. This subunit plays a critical role in the transfer of electrons from NADH to ubiquinone facilitating energy conversion within the cell.

Biological function summary

MT-ND3 contributes to essential energy metabolism processes by being integrated into Complex I also known as NADH: ubiquinone oxidoreductase. This complex is integral to maintaining cellular energy homeostasis as it catalyzes the initial step in oxidative phosphorylation. As part of the large multi-subunit Complex I MT-ND3 along with other subunits assists in proton translocation across the mitochondrial membrane which is indispensable for generating an electrochemical gradient used in ATP synthesis.

Pathways

The MT-ND3 subunit plays a role in the electron transport chain and oxidative phosphorylation pathways. It collaborates with other complex subunits like MT-ND1 and MT-ND2 to facilitate electron flow and proton pumping. These pathways are central to cellular respiration influencing how cells extract energy from nutrients. MT-ND3 is indirectly involved with other proteins like cytochrome c which further participates in the cascade of electron transfer leading to ATP production.

Mutations in the MT-ND3 gene have been linked to mitochondrial disorders such as Leber's hereditary optic neuropathy (LHON) and mitochondrial encephalomyopathy. These conditions often manifest due to disrupted oxidative phosphorylation leading to reduced ATP availability and increased reactive oxygen species production. MT-ND3 dysfunction might also impact other mitochondrial components like MT-CO1 as these proteins collectively impact energy production and cellular health.

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产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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靶点信息

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor (PubMed : 25118196). Essential for the catalytic activity of complex I (PubMed : 25118196).

See full target information MT-ND3

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文献 (10)

Recent publications for all applications. Explore the full list and refine your search

Cancer research 84:3761-3771 PubMed39207369

2024

Live-Cell Invasive Phenotyping Uncovers ALK2 as a Therapeutic Target in LKB1-Mutant Lung Cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Junghui Koo,Chang-Soo Seong,Rebecca E Parker,Amy Herrera,Bhakti Dwivedi,Robert A Arthur,Ashok Reddy Dinasarapu,Henry Richard Johnston,Henry Claussen,Carol Tucker-Burden,Suresh S Ramalingam,Haian Fu,Wei Zhou,Adam I Marcus,Melissa Gilbert-Ross

Cell discovery 10:11 PubMed38291322

2024

Structural insights into the specific recognition of mitochondrial ribosome-binding factor hsRBFA and 12 S rRNA by methyltransferase METTL15.

Applications

Unspecified application

Species

Unspecified reactive species

Mengqi Lv,Wanwan Zhou,Yijie Hao,Fudong Li,Huafeng Zhang,Xuebiao Yao,Yunyu Shi,Liang Zhang

Journal of biomedical science 30:63 PubMed37537557

2023

Optimized allotopic expression of mitochondrial ND6 transgene restored complex I and apoptosis deficiencies caused by LHON-linked ND6 14484T > C mutation.

Applications

Unspecified application

Species

Unspecified reactive species

Jing Wang,Yanchun Ji,Cheng Ai,Jia-Rong Chen,Dingyi Gan,Juanjuan Zhang,Jun Q Mo,Min-Xin Guan

Animals : an open access journal from MDPI 13: PubMed37174479

2023

Glucose Starvation Inhibits Ferroptosis by Activating the LKB1/AMPK Signaling Pathway and Promotes the High Speed Linear Motility of Dairy Goat Sperm.

Applications

Unspecified application

Species

Unspecified reactive species

Yu Li,Guangzhi Zhang,Fei Wen,Ming Xian,Songmao Guo,Xing Zhang,Xianzhou Feng,Zhangtao Hu,Jianhong Hu

Oxidative medicine and cellular longevity 2022:8038857 PubMed35087620

2022

Clinical Relevance and Tumor Growth Suppression of Mitochondrial ROS Regulators along NADH:Ubiquinone Oxidoreductase Subunit B3 in Thyroid Cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Jiao Zhu,Xiaobo Zheng,Dan Lu,Yun Zheng,Jun Liu

Nature cell biology 23:684-691 PubMed34253897

2021

ALKBH7-mediated demethylation regulates mitochondrial polycistronic RNA processing.

Applications

Unspecified application

Species

Unspecified reactive species

Li-Sheng Zhang,Qing-Ping Xiong,Sonia Peña Perez,Chang Liu,Jiangbo Wei,Cassy Le,Linda Zhang,Bryan T Harada,Qing Dai,Xinran Feng,Ziyang Hao,Yuru Wang,Xueyang Dong,Lulu Hu,En-Duo Wang,Tao Pan,Arne Klungland,Ru-Juan Liu,Chuan He

International journal of biological sciences 17:1693-1707 PubMed33994854

2021

Berberine alleviates lipid metabolism disorders via inhibition of mitochondrial complex I in gut and liver.

Applications

Unspecified application

Species

Unspecified reactive species

Muyu Yu,Miriayi Alimujiang,Lili Hu,Fang Liu,Yuqian Bao,Jun Yin

Journal of cellular and molecular medicine : PubMed32954626

2020

Involvement of kindlin-2 in irisin's protection against ischaemia reperfusion-induced liver injury in high-fat diet-fed mice.

Applications

Unspecified application

Species

Unspecified reactive species

Jia Zhang,Yifan Ren,Jianbin Bi,Mengzhou Wang,Lin Zhang,Tao Wang,Shasha Wei,Xingyi Mou,Yi Lv,Rongqian Wu

Journal of cellular physiology 236:931-945 PubMed32583428

2020

Involvement of GPX4 in irisin's protection against ischemia reperfusion-induced acute kidney injury.

Applications

Unspecified application

Species

Unspecified reactive species

Jia Zhang,Jianbin Bi,Yifan Ren,Zhaoqing Du,Teng Li,Tao Wang,Lin Zhang,Mengzhou Wang,Shasha Wei,Yi Lv,Rongqian Wu

Journal of neurochemistry 146:585-597 PubMed29779213

2018

Differential toxicity of TAR DNA-binding protein 43 isoforms depends on their submitochondrial localization in neuronal cells.

Applications

Unspecified application

Species

Unspecified reactive species

Illari Salvatori,Alberto Ferri,Silvia Scaricamazza,Ilaria Giovannelli,Alessia Serrano,Simona Rossi,Nadia D'Ambrosi,Mauro Cozzolino,Andrea Di Giulio,Sandra Moreno,Cristiana Valle,Maria Teresa Carrì

View all publications

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Abcam Product Promise

我们致力于为您的研究提供高质量的试剂，为您科研的每一步提供支持。若我们的产品未能达到预期性能，我们向您提供 Abcam Product Promise 保障。

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Anti-MT-ND3抗体

Anti-MT-ND3 antibody

Western blot - Anti-MT-ND3 antibody (AB192306)

关键信息

宿主种属

克隆

亚型

不含载体蛋白

反应种属

应用

免疫原

反应性数据

性能和储存信息

形式

纯化工艺

纯化说明

存储溶液

运输条件

推荐的短期储存时间

推荐的短期储存条件

推荐的长期储存条件

分装信息

储存信息

补充信息

Biological function summary

Pathways

产品实验方案

靶点信息

文献 (10)

Abcam Product Promise

Anti-MT-ND3抗体

Anti-MT-ND3 antibody

Western blot - Anti-MT-ND3 antibody (AB192306)

关键信息

宿主种属

克隆

亚型

不含载体蛋白

反应种属

应用

免疫原

替代产品

Primary Antibodies

搭配使用产品

Primary Antibodies

Primary Antibodies

Primary Antibodies

Reagents, Controls & Accessories

反应性数据

性能和储存信息

形式

纯化工艺

纯化说明

存储溶液

运输条件

推荐的短期储存时间

推荐的短期储存条件

推荐的长期储存条件

分装信息

储存信息

补充信息

Biological function summary

Pathways

产品实验方案

靶点信息

文献 (10)

Abcam Product Promise