AB154829

重组Anti-MSY2/YBOX2/YBX2抗体[EPR2814(2)]

Name: MSY2/YBOX2/YBX2抗体[EPR2814(2)] (ab154829)| Abcam中文官网
Brand: Abcam Limited
SKU: AB154829
Price: 2217 CNY
Availability: InStock
Rating: 1 (1 reviews)

Anti-MSY2/YBOX2/YBX2 antibody [EPR2814(2)]

RabMAb
Recombinant
了解详情

(1 Review)

(7 Publications)

Rabbit Recombinant Monoclonal MSY2/YBOX2/YBX2 antibody. Suitable for WB, ICC/IF and reacts with Human, Mouse, Rat samples. Cited in 7 publications.

查看别名

CSDA3, MSY2, YBX2, Y-box-binding protein 2, Contrin, DNA-binding protein C, Germ cell-specific Y-box-binding protein, MSY2 homolog, Dbpc

2 Images

Immunocytochemistry/ Immunofluorescence - Anti-MSY2/YBOX2/YBX2 antibody [EPR2814(2)] (AB154829)

ICC/IF

Unknown

Immunocytochemistry/ Immunofluorescence - Anti-MSY2/YBOX2/YBX2 antibody [EPR2814(2)] (AB154829)

Immunofluorescent analysis of HepG2 cells labeling MSY2/YBOX2/YBX2 with ab154829 at 1/50 dilution.

Unknown

Western blot - Anti-MSY2/YBOX2/YBX2 antibody [EPR2814(2)] (AB154829)

All lanes:

Western blot - Anti-MSY2/YBOX2/YBX2 antibody [EPR2814(2)] (ab154829) at 1/1000 dilution

Lane 1:

Human seminoma lysate at 10 µg

Lane 2:

Mouse testis lysate at 10 µg

Lane 3:

Rat testis lysate at 10 µg

Secondary

All lanes:

Goat anti-rabbit HRP at 1/2000 dilution

Predicted band size: 38 kDa

false

不同偶联物与剂型 (1)

Carrier free

Anti-MSY2/YBOX2/YBX2 antibody [EPR2814(2)] - BSA and Azide free

关键信息

宿主种属

Rabbit

克隆

Monoclonal

克隆号

EPR2814(2)

亚型

IgG

不含载体蛋白

反应种属

Mouse, Rat, Human

应用

WB, ICC/IF

applications

免疫原

The exact immunogen used to generate this antibody is proprietary information.

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000 - 1/10000", "WB-species-notes": "", "IHCP-species-checked": "notRecommended", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "1/50 - 1/100", "ICCIF-species-notes": "" }, "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000 - 1/10000", "WB-species-notes": "", "IHCP-species-checked": "notRecommended", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "guaranteed", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Rat": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000 - 1/10000", "WB-species-notes": "", "IHCP-species-checked": "notRecommended", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "guaranteed", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" } } }

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产品详情

Patented technology
Our RabMAb^® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb^® patents.

What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:

- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production

For more information, read more on recombinant antibodies.

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性能和储存信息

形式

Liquid

纯度

Tissue culture supernatant

存储溶液

pH: 7.2 - 7.4 Preservative: 0.01% Sodium azide Constituents: PBS, 50% Tissue culture supernatant, 40% Glycerol (glycerin, glycerine), 0.05% BSA

运输条件

Blue Ice

补充信息

This supplementary information is collated from multiple sources and compiled automatically.

MSY2 also known as YBOX2 or YBX2 is a protein involved in gene regulation specifically affecting mRNA stability and translation. The protein has a molecular mass of approximately 36 kDa. MSY2 is a germ cell-specific protein primarily expressed in testes and ovaries. It plays an important role during gametogenesis and early embryogenesis by binding with mRNA and forming messenger ribonucleoprotein (mRNP) complexes and therefore controlling mRNA metabolism.

Biological function summary

MSY2 functions as a regulator of mRNA translation and storage. It is part of a ribonucleoprotein complex that safeguards mRNAs during gametogenesis. This protein displays specificity in binding to Y-box motifs on mRNA which allows it to regulate gene expression and protein synthesis at a posttranscriptional level. Its function ensures correct development of germ cells contributing to reproductive success.

Pathways

MSY2 integrates into posttranscriptional regulatory mechanisms and is important for mRNA stability within these pathways. One such pathway involves cytoplasmic deadenylation and translational control during oocyte maturation. MSY2’s role also extends to working closely with other proteins such as YBX1 which shares similar functions in mRNA regulation further highlighting the interconnected nature of its activity.

MSY2’s deregulation can lead to fertility issues particularly affecting spermatogenesis. Aberrant expression of MSY2 affects mRNA stability and may result in testicular dysfunction. It also connects with proteins like DAZL which is another germ cell-specific regulator suggesting that perturbations in this network can affect germ cell viability and lead to reproductive disorders. Proper expression and regulation of MSY2 are therefore essential for maintaining reproductive health.

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产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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靶点信息

Major constituent of messenger ribonucleoprotein particles (mRNPs). Involved in the regulation of the stability and/or translation of germ cell mRNAs. Binds to Y-box consensus promoter element. Binds to full-length mRNA with high affinity in a sequence-independent manner. Binds to short RNA sequences containing the consensus site 5'-UCCAUCA-3' with low affinity and limited sequence specificity. Its binding with maternal mRNAs is necessary for its cytoplasmic retention. May mark specific mRNAs (those transcribed from Y-box promoters) in the nucleus for cytoplasmic storage, thereby linking transcription and mRNA storage/translational delay (By similarity).

See full target information YBX2

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文献 (7)

Recent publications for all applications. Explore the full list and refine your search

Journal of cellular and molecular medicine 28:e18022 PubMed37929660

2023

PIN1P1 is activated by CREB1 and promotes gastric cancer progression via interacting with YBX1 and upregulating PIN1.

Applications

Unspecified application

Species

Unspecified reactive species

Ya-Wen Wang,Wen-Jie Zhu,Ran-Ran Ma,Ya-Ru Tian,Xu Chen,Peng Gao

iScience 26:108091 PubMed37860762

2023

Phosphorylated YBX2 is stabilized to promote glycolysis in brown adipocytes.

Applications

Unspecified application

Species

Unspecified reactive species

Qingwen Zhao,Chao Yu,Xiaoxuan Xu,Wenfang Jin,Zhe Zhang,Haiyan Huang,Yue Gao,Dongning Pan

Cells 12: PubMed37408260

2023

Cold Shock Domain Protein DbpA Orchestrates Tubular Cell Damage and Interstitial Fibrosis in Inflammatory Kidney Disease.

Applications

Unspecified application

Species

Unspecified reactive species

Jonathan A Lindquist,Anja Bernhardt,Charlotte Reichardt,Eva Sauter,Sabine Brandt,Rajiv Rana,Maja T Lindenmeyer,Lars Philipsen,Berend Isermann,Cheng Zhu,Peter R Mertens

International journal of molecular medicine 50: PubMed35929517

2022

Effects and potential mechanism of Ca/calmodulin‑dependent protein kinase II pathway inhibitor KN93 on the development of ovarian follicle.

Applications

Unspecified application

Species

Unspecified reactive species

Jianjie Yu,Xianguo Xie,Yabo Ma,Yi Yang,Chao Wang,Guoliang Xia,Xiangbin Ding,Xinfeng Liu

Epigenetics & chromatin 14:3 PubMed33407810

2021

Genome-wide occupancy reveals the localization of H1T2 (H1fnt) to repeat regions and a subset of transcriptionally active chromatin domains in rat spermatids.

Applications

Unspecified application

Species

Unspecified reactive species

Vasantha Shalini,Utsa Bhaduri,Anjhana C Ravikkumar,Anusha Rengarajan,Rao M R Satyanarayana

Cancer biology & therapy 20:1270-1280 PubMed31161900

2019

LINC00958 regulated miR-627-5p/YBX2 axis to facilitate cell proliferation and migration in oral squamous cell carcinoma.

Applications

Unspecified application

Species

Unspecified reactive species

Fuyang Chen,Mingyue Liu,Yixiu Yu,Yanyan Sun,Jihe Li,Weiping Hu,Xiaofeng Wang,Dongxia Tong

Biology of reproduction 100:561-572 PubMed30295753

2018

Murine PAIP1 stimulates translation of spermiogenic mRNAs stored by YBX2 via its interaction with YBX2†.

Applications

Unspecified application

Species

Unspecified reactive species

Yue He,Yu Lin,Yu Zhu,Ping Ping,Guishuan Wang,Fei Sun

View all publications

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重组Anti-MSY2/YBOX2/YBX2抗体[EPR2814(2)]