Anti-Msx2/Hox8抗体(ab223692)
Key features and details
- Rabbit polyclonal to Msx2/Hox8
- Suitable for: IHC-P
- Reacts with: Human
- Isotype: IgG
概述
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产品名称
Anti-Msx2/Hox8抗体
参阅全部 Msx2/Hox8 一抗 -
描述
兔多克隆抗体to Msx2/Hox8 -
宿主
Rabbit -
经测试应用
适用于: IHC-Pmore details -
种属反应性
与反应: Human
预测可用于: Cow, Chimpanzee, Gorilla
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免疫原
Recombinant fragment corresponding to Human Msx2/Hox8 aa 1-150.
Database link: P35548 -
阳性对照
- IHC-P: Human endometrium, placenta and urinary bladder tissue.
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常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle. -
存储溶液
pH: 7.20
Preservative: 0.02% Sodium azide
Constituents: 40% Glycerol (glycerin, glycerine), PBS -
Concentration information loading... -
纯度
Immunogen affinity purified -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab223692于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度；实际最佳的稀释度/浓度应由使用者检定。
| 应用 | Ab评论 | 说明 |
|---|---|---|
| IHC-P |
1/50 - 1/200. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.
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| 说明 |
|---|
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IHC-P
1/50 - 1/200. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol. |
靶标
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功能
Acts as a transcriptional regulator in bone development. Represses the ALPL promoter activity and antogonizes the stimulatory effect of DLX5 on ALPL expression during osteoblast differentiation. Probable morphogenetic role. May play a role in limb-pattern formation. In osteoblasts, suppresses transcription driven by the osteocalcin FGF response element (OCFRE). Binds to the homeodomain-response element of the ALPL promoter. -
疾病相关
Defects in MSX2 are the cause of parietal foramina 1 (PFM1) [MIM:168500]; also known as foramina parietalia permagna (FPP). PFM1 is an autosomal dominant disease characterized by oval defects of the parietal bones caused by deficient ossification around the parietal notch, which is normally obliterated during the fifth fetal month.
Defects in MSX2 are the cause of parietal foramina with cleidocranial dysplasia (PFMCCD) [MIM:168550]; also known as cleidocranial dysplasia with parietal foramina. PFMCCD combines skull defects in the form of enlarged parietal foramina and deficient ossification of the clavicles.
Defects in MSX2 are the cause of craniosynostosis type 2 (CRS2) [MIM:604757]; also known as craniosynostosis Boston-type (CSB). CRS2 is an autosomal dominant disorder characterized by the premature fusion of calvarial sutures. The craniosynostosis phenotype is either fronto-orbital recession, or frontal bossing, or turribrachycephaly, or cloverleaf skull. Associated features include severe headache, high incidence of visual problems (myopia or hyperopia), and short first metatarsals. Intelligence is normal. -
序列相似性
Belongs to the Msh homeobox family.
Contains 1 homeobox DNA-binding domain. -
细胞定位
Nucleus. - Information by UniProt
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数据库链接
- Entrez Gene: 744194 Chimpanzee
- Entrez Gene: 540230 Cow
- Entrez Gene: 101131683 Gorilla
- Entrez Gene: 4488 Human
- Omim: 123101 Human
- SwissProt: A2T764 Chimpanzee
- SwissProt: Q0P5C3 Cow
- SwissProt: A1YF16 Gorilla
see all -
别名
- CRS 2 antibody
- CRS2 antibody
- FPP antibody
see all
图片
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Msx2/Hox8 antibody (ab223692)
Formalin-fixed, paraffin-embedded human endometrium tissue stained for Msx2/Hox8 using ab223692 at 1/50 dilution in immunohistochemical analysis.
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Msx2/Hox8 antibody (ab223692)Formalin-fixed, paraffin-embedded human placenta tissue stained for Msx2/Hox8 using ab223692 at 1/50 dilution in immunohistochemical analysis.
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Msx2/Hox8 antibody (ab223692)Formalin-fixed, paraffin-embedded human urinary bladder tissue stained for Msx2/Hox8 using ab223692 at 1/50 dilution in immunohistochemical analysis.
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Msx2/Hox8 antibody (ab223692)Formalin-fixed, paraffin-embedded human endometrium tissue stained for Msx2/Hox8 using ab223692 at 1/50 dilution in immunohistochemical analysis. Low positivity, as expected.
数据表及文件
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SDS download
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Datasheet download
文献 (8)
ab223692 被引用在 8 文献中.
- Zhang Q et al. Role of follistatin-like 1 levels and functions in calcific aortic stenosis. Front Cardiovasc Med 9:1050310 (2022). PubMed: 36684598
- Wu Y et al. MSX2 inhibits the growth and migration of osteosarcoma cells by repressing SOX2. Am J Transl Res 13:5851-5865 (2021). PubMed: 34306330
- Jain N & Pilmane M Evaluating the Expression of Candidate Homeobox Genes and Their Role in Local-Site Inflammation in Mucosal Tissue Obtained from Children with Non-Syndromic Cleft Lip and Palate. J Pers Med 11:N/A (2021). PubMed: 34834487
- Cai C et al. Msx2 plays an important role in BMP6-induced osteogenic differentiation of two mesenchymal cell lines: C3H10T1/2 and C2C12. Regen Ther 14:245-251 (2020). PubMed: 32455154
- Son C et al. Different Responsiveness of Alveolar Bone and Long Bone to Epithelial-Mesenchymal Interaction-Related Factor. JBMR Plus 4:e10382 (2020). PubMed: 32803111
- Wang C et al. Poly(ADP-ribose) polymerase 1 accelerates vascular calcification by upregulating Runx2. Nat Commun 10:1203 (2019). PubMed: 30867423
- Li Y et al. CTRP13 attenuates vascular calcification by regulating Runx2. FASEB J 33:9627-9637 (2019). PubMed: 31145871
- Jiang Y et al. Histological study of postnatal development of mouse tongues. Exp Ther Med 15:383-386 (2018). PubMed: 29375694