AB272591

Anti-MNK2抗体

Name: MNK2抗体 (ab272591)| Abcam中文官网
Brand: Abcam Limited
SKU: AB272591
Price: 5965 CNY
Availability: InStock

Anti-MNK2 antibody

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(1 Publication)

Rabbit Polyclonal MNK2 antibody. Suitable for IHC-P, WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human MKNK2 aa 1-150.

查看别名

GPRK7, MNK2, MKNK2, MAP kinase-interacting serine/threonine-protein kinase 2, MAP kinase signal-integrating kinase 2, MAPK signal-integrating kinase 2, Mnk2

2 Images

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MNK2 antibody (AB272591)

IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MNK2 antibody (AB272591)

Paraffin-embedded formalin-fixed Human gall bladder tissue stained for MNK2 using ab272591 at 1/50 in immunohistochemical analysis.

Supplier Data

Western blot - Anti-MNK2 antibody (AB272591)

Western blot analysis labeling MNK2 with ab272591 at 0.04 ug/ml.

All lanes:

Western blot - Anti-MNK2 antibody (ab272591) at 0.04 µg/mL

All lanes:

SK-MEL-30 cell lysate

Predicted band size: 52 kDa

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关键信息

宿主种属

Rabbit

克隆

Polyclonal

亚型

IgG

不含载体蛋白

反应种属

Human

应用

IHC-P, WB

applications

免疫原

Recombinant Fragment Protein within Human MKNK2 aa 1-150. The exact immunogen used to generate this antibody is proprietary information.

Q9HBH9

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/20 - 1/50", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.04-0.4 µg/mL", "WB-species-notes": "<p></p>" } } }

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性能和储存信息

形式

Liquid

纯化工艺

Affinity purification Immunogen

存储溶液

pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)

运输条件

Blue Ice

分装信息

Upon delivery aliquot

储存信息

Avoid freeze / thaw cycle

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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

The MNK2 kinase also known as MAP kinase-interacting serine/threonine-protein kinase 2 is a protein that plays a critical role in regulating mRNA translation. It weighs approximately 51 kDa and is part of the larger mitogen-activated protein kinase (MAPK) family. This protein is expressed widely across various tissues including the brain and liver. Its primary function is to phosphorylate specific substrates involved in the process of gene expression control.

Biological function summary

MNK2 modulates stress responses by influencing protein synthesis. It is an integral component of the mRNA translation machinery. MNK2 phosphorylates the eukaryotic translation initiation factor 4E (eIF4E) a process that is fundamental for the translation of specific mRNAs. By regulating eIF4E activity MNK2 helps to control the translation of mRNAs involved in stress response and cellular growth.

Pathways

MNK2 is significantly involved in the MAPK signaling pathway and plays a role in the response to cellular stress and growth signals. This pathway includes MAP kinases like ERK which activate MNK2. Through its interaction with eIF4E MNK2 facilitates the synthesis of proteins that are important for cell survival and proliferation in response to extracellular signals. Its action links upstream signaling events influenced by MAP kinases to downstream processes affecting cell growth and stress response.

MNK2 has been implicated in cancer due to its role in the regulation of protein synthesis that supports cell proliferation. Abnormal MNK2 activity is linked to tumorigenesis particularly in cancers where eIF4E plays a role like breast and prostate cancer. Moreover its interaction with proteins such as eIF4E and MAP kinases highlights potential targets for therapeutic intervention. By modulating MNK2 activity researchers aim to control aberrant protein synthesis pathways driving these diseases.

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产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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靶点信息

Serine/threonine-protein kinase that phosphorylates SFPQ/PSF, HNRNPA1 and EIF4E. May play a role in the response to environmental stress and cytokines. Appears to regulate translation by phosphorylating EIF4E, thus increasing the affinity of this protein for the 7-methylguanosine-containing mRNA cap. Required for mediating PP2A-inhibition-induced EIF4E phosphorylation. Triggers EIF4E shuttling from cytoplasm to nucleus. Isoform 1 displays a high basal kinase activity, but isoform 2 exhibits a very low kinase activity. Acts as a mediator of the suppressive effects of IFNgamma on hematopoiesis. Negative regulator for signals that control generation of arsenic trioxide As(2)O(3)-dependent apoptosis and anti-leukemic responses. Involved in anti-apoptotic signaling in response to serum withdrawal.

See full target information MKNK2

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文献 (1)

Recent publications for all applications. Explore the full list and refine your search

Frontiers in oncology 11:683582 PubMed34222004

2021

Novel Prognostic Biomarkers in Gastric Cancer: CGB5, MKNK2, and PAPPA2.

Applications

Unspecified application

Species

Unspecified reactive species

Min Qin,Zhihai Liang,Heping Qin,Yifang Huo,Qing Wu,Huiying Yang,Guodu Tang

View all publications

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Anti-MNK2抗体

Anti-MNK2 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MNK2 antibody (AB272591)

Western blot - Anti-MNK2 antibody (AB272591)