Anti-MMP2抗体[MMP2/1501]
Anti-MMP2 antibody [MMP2/1501]
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(1 Publication)
Mouse Monoclonal MMP2 antibody. Suitable for WB, Protein Array and reacts with Recombinant fragment, Human, Recombinant full length protein - Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human MMP2 aa 400 to C-terminus.
查看别名
CLG4A, MMP2, 72 kDa type IV collagenase, 72 kDa gelatinase, Gelatinase A, Matrix metalloproteinase-2, TBE-1, MMP-2
- Protein Array
Unknown
Protein Array - Anti-MMP2 antibody [MMP2/1501] (AB218462)
ab218462 was tested in protein array against over 19000 different full-length human proteins.
Z- and S- Score : The Z-score represents the strength of a signal that a monoclonal antibody (MAb) (in combination with a fluorescently-tagged anti-IgG secondary antibody) produces when binding to a particular protein on the HuProtTM array. Z-scores are described in units of standard deviations (SD's) above the mean value of all signals generated on that array. If targets on HuProtTM are arranged in descending order of the Z-score, the S-score is the difference (also in units of SD's) between the Z-score. S-score therefore represents the relative target specificity of a MAb to its intended target.
A MAb is specific to its intended target if the MAb has an S-score of at least 2.5. For example, if a MAb binds to protein X with a Z-score of 43 and to protein Y with a Z-score of 14, then the S-score for the binding of that MAb to protein X is equal to 29.
- WB
Supplier Data
Western blot - Anti-MMP2 antibody [MMP2/1501] (AB218462)
All lanes:
Western blot - Anti-MMP2 antibody [MMP2/1501] (ab218462) at 1 µg/mL
Lane 1:
Recombinant MMP2 protein
Lane 2:
U87 cell lysate
Predicted band size: 70 kDa,73 kDa
false
反应性数据
性能和储存信息
形式
纯化工艺
存储溶液
运输条件
推荐的短期储存时间
推荐的短期储存条件
推荐的长期储存条件
分装信息
储存信息
补充信息
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
Matrix metalloproteinase-2 is mainly involved in the degradation of type IV and V collagens gelatin and fibronectin. As part of the metalloproteinase family it works alongside other MMPs to maintain tissue homeostasis and repair. MMP-2 forms part of a complex network that ensures the timely degradation of matrix components balancing synthesis and breakdown. It remains regulated by tissue inhibitors of metalloproteinases (TIMPs) preventing excessive degradation that could lead to tissue damage.
Pathways
MMP-2 plays a significant role within the extracellular matrix (ECM) remodeling and angiogenesis pathways. It interacts with various proteins including integrins and TIMP-2 to modulate cellular behaviors such as migration and invasion. MMP-2 contributes to processes like wound healing and embryonic development through its involvement in ECM degradation and new tissue formation.
产品实验方案
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靶点信息
文献 (1)
Recent publications for all applications. Explore the full list and refine your search
Med (New York, N.Y.) 4:554-579.e9 PubMed37572651
2023
Applications
Unspecified application
Species
Unspecified reactive species
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