Anti-MMP13抗体[M33] (ab1010)
Key features and details
- Mouse monoclonal [M33] to MMP13
- Suitable for: ELISA
- Reacts with: Human
- Isotype: IgG1
概述
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产品名称
Anti-MMP13抗体[M33]
参阅全部 MMP13 一抗 -
描述
小鼠单克隆抗体[M33] to MMP13 -
宿主
Mouse -
特异性
Based on Western blotting, the antibody reacts with human procollagenase-3. The antibody does not cross react with MT1-MMP latent form (MMP-14), MT2-MMP catalytic domain (MMP-15), MT3-MMP catalytic domain (MMP-16), MT4-MMP catalytic domain (MMP-17), MT5-MMP catalytic domain (MMP-18), Gelatinase A (MMP-2) latent form, Gelatinase B (MMP-9) latent form or Collagenase 2 (MMP-8) latent form. -
经测试应用
适用于: ELISAmore details -
种属反应性
与反应: Human -
免疫原
Recombinant full length protein corresponding to Human MMP13. Recombinant human procollagenase-3 expressed in insect cells
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常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle. -
存储溶液
Preservative: 0.01% Sodium azide -
Concentration information loading...
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纯度
Protein G purified -
克隆
单克隆 -
克隆编号
M33 -
同种型
IgG1 -
轻链类型
unknown -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
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Recombinant Protein
应用
应用 | Ab评论 | 说明 |
---|---|---|
ELISA |
1/1000 - 1/2000.
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说明 |
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ELISA
1/1000 - 1/2000. |
靶标
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功能
Degrades collagen type I. Does not act on gelatin or casein. Could have a role in tumoral process. -
组织特异性
Seems to be specific to breast carcinomas. -
疾病相关
Defects in MMP13 are the cause of spondyloepimetaphyseal dysplasia Missouri type (SEMD-MO) [MIM:602111]. A bone disease characterized by moderate to severe metaphyseal changes, mild epiphyseal involvement, rhizomelic shortening of the lower limbs with bowing of the femora and/or tibiae, coxa vara, genu varum and pear-shaped vertebrae in childhood. Epimetaphyseal changes improve with age.
Defects in MMP13 are the cause of metaphyseal anadysplasia type 1 (MANDP1) [MIM:602111]. Metaphyseal anadysplasia consists of an abnormal bone development characterized by severe skeletal changes that, in contrast with the progressive course of most other skeletal dysplasias, resolve spontaneously with age. Clinical characteristics are evident from the first months of life and include slight shortness of stature and a mild varus deformity of the legs. Patients attain a normal stature in adolescence and show improvement or complete resolution of varus deformity of the legs and rhizomelic micromelia. -
序列相似性
Belongs to the peptidase M10A family.
Contains 4 hemopexin-like domains. -
结构域
The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme. -
细胞定位
Secreted > extracellular space > extracellular matrix. - Information by UniProt
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数据库链接
- Entrez Gene: 4322 Human
- Omim: 600108 Human
- SwissProt: P45452 Human
- Unigene: 2936 Human
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别名
- CLG 3 antibody
- CLG3 antibody
- Collagenase 3 antibody
see all
数据表及文件
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Datasheet download
文献 (1)
ab1010 被引用在 1 文献中.
- Song JH et al. Expression of platelet-derived growth factor receptor-a/ß, vascular endothelial growth factor receptor-2, c-Abl, and c-Kit in canine granulomatous meningoencephalitis and necrotizing encephalitis. Vet Med Sci 6:965-974 (2020). PubMed: 32585777