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重组RabMAb

重组Anti-MMAB抗体[EPR8695] (ab174831)

Submit a review Submit a question References (1)
Western blot - Anti-MMAB antibody [EPR8695] (ab174831)
  • Immunocytochemistry/ Immunofluorescence - Anti-MMAB antibody [EPR8695] (ab174831)
  • Anti-MMAB antibody [EPR8695] (ab174831)

Key features and details

  • Produced recombinantly (animal-free) for high batch-to-batch consistency and long term security of supply
  • Rabbit monoclonal [EPR8695] to MMAB
  • Suitable for: WB, ICC/IF
  • Reacts with: Human

Conjugates logo Related conjugates and formulations

Carrier Free

概述

  • 产品名称

    Anti-MMAB抗体[EPR8695]
    参阅全部 MMAB 一抗

  • 描述

    兔单克隆抗体[EPR8695] to MMAB

  • 宿主

    Rabbit

  • 经测试应用

    适用于: WB, ICC/IFmore details
    不适用于: Flow Cyt,IHC-P or IP

  • 种属反应性

    与反应: Human
    预测可用于: Rat不与反应: Mouse

  • 免疫原

    Synthetic peptide within Human MMAB aa 1-100 (Cysteine residue). The exact sequence is proprietary.
    Database link: Q96EY8

  • 阳性对照

    • HepG2, A673 and Human fetal liver lysates; HepG2 cells.

  • 常规说明

    This product is a recombinant monoclonal antibody, which offers several advantages including:

    • - High batch-to-batch consistency and reproducibility
    • - Improved sensitivity and specificity
    • - Long-term security of supply
    • - Animal-free production
    For more information see here.

    Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.

性能

应用

The Abpromise guarantee

Abpromise™承诺保证使用ab174831于以下的经测试应用

“应用说明”部分 下显示的仅为推荐的起始稀释度；实际最佳的稀释度/浓度应由使用者检定。

应用 Ab评论 说明
WB
1/1000 - 1/10000. Predicted molecular weight: 27 kDa.
ICC/IF
1/50 - 1/100.
说明
WB
1/1000 - 1/10000. Predicted molecular weight: 27 kDa.
ICC/IF
1/50 - 1/100.
应用说明
Is unsuitable for Flow Cyt,IHC-P or IP.

靶标

  • 组织特异性

    Expressed in liver and skeletal muscle.

  • 通路

    Cofactor biosynthesis; adenosylcobalamin biosynthesis; adenosylcobalamin from cob(II)yrinate a,c-diamide: step 2/7.

  • 疾病相关

    Defects in MMAB are the cause of methylmalonic aciduria type cblB (MMAB) [MIM:251110]; also known as methylmalonic aciduria type B or vitamin B12-responsive methylmalonicaciduria of cblB complementation type. MMAB is a disorder of methylmalonate and cobalamin metabolism due to defective synthesis of adenosylcobalamin. Inheritance is autosomal recessive.

  • 序列相似性

    Belongs to the Cob(I)alamin adenosyltransferase family.

  • 细胞定位

    Mitochondrion.
  • Information by UniProt

  • 数据库链接

    • 别名

      • aquocob(I)alamin vitamin B12s adenosyltransferase antibody
      • ATP:cob(I)alamin adenosyltransferase antibody
      • ATP:corrinoid adenosyltransferase antibody
      • ATR antibody
      • c-diamide adenosyltransferase antibody
      • cblB antibody
      • Cob antibody
      • Cob(I)alamin adenosyltransferase antibody
      • Cob(I)yrinic acid a antibody
      • cob(I)yrinic acid a c diamide adenosyltransferase mitochondrial antibody
      • Methylmalonic aciduria (cobalamin deficiency) cblB type antibody
      • Methylmalonic aciduria type B protein antibody
      • MGC20496 antibody
      • mitochondrial antibody
      • MMAB antibody
      • MMAB gene antibody
      • MMAB_HUMAN antibody
      • OTTHUMP00000240563 antibody
      • OTTHUMP00000240564 antibody
      see all

    图片

    • Western blot - Anti-MMAB antibody [EPR8695] (ab174831)
      Western blot - Anti-MMAB antibody [EPR8695] (ab174831)
      All lanes : Anti-MMAB antibody [EPR8695] (ab174831) at 1/1000 dilution

      Lane 1 : HepG2 cell lysate
      Lane 2 : Human fetal liver tissue lysate
      Lane 3 : A673 cell lysate

      Lysates/proteins at 10 µg per lane.

      Secondary
      All lanes : Goat anti-rabbit HRP at 1/2000 dilution

      Developed using the ECL technique.

      Predicted band size: 27 kDa

    • Immunocytochemistry/ Immunofluorescence - Anti-MMAB antibody [EPR8695] (ab174831)
      Immunocytochemistry/ Immunofluorescence - Anti-MMAB antibody [EPR8695] (ab174831)

      Immunofluorescent analysis of HepG2 cells, labeling MMAB with ab174831 at 1/50 dilution (green). DAPI nuclear staining (blue).

    • Anti-MMAB antibody [EPR8695] (ab174831)
      Anti-MMAB antibody [EPR8695] (ab174831)

    文献 (1)

    发表研究结果有使用 ab174831？请让我们知道，以便我们可以引用本数据表中的参考文章。

    ab174831 被引用在 1 文献中.

    • Gomes AP  et al. Altered propionate metabolism contributes to tumour progression and aggressiveness. Nat Metab 4:435-443 (2022). PubMed: 35361954

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